57 items (Salmo salar) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC106566708	G2/mitotic-specific cyclin-B1-like; Belongs to the cyclin family. (403 aa)
	tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (454 aa)
	atg10	Ubiquitin-like-conjugating enzyme ATG10. (282 aa)
	ccnb3	G2/mitotic-specific cyclin-B3; Belongs to the cyclin family. (414 aa)
	LOC106612018	Caspase-3-like; Belongs to the peptidase C14A family. (283 aa)
	epg5	LOW QUALITY PROTEIN: ectopic P granules protein 5 homolog. (2359 aa)
	LOC106576719	Caspase-2-like isoform X1; Belongs to the peptidase C14A family. (485 aa)
	nod2	Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1002 aa)
	LOC106573350	CD44 antigen-like. (472 aa)
	LOC100136370	Rhodopsin. (354 aa)
	BCL2	Apoptosis regulator Bcl-2-like. (230 aa)
	LOC100380690	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (552 aa)
	LOC106561972	Apoptosis regulator BAX-like. (204 aa)
	casp3	Caspase 3B; Belongs to the peptidase C14A family. (311 aa)
	cdk2	Cell division protein kinase 2; Belongs to the protein kinase superfamily. (298 aa)
	ccnb1	G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (401 aa)
	CASP2	Caspase-2-like; Belongs to the peptidase C14A family. (343 aa)
	lck	Tyrosine-protein kinase. (509 aa)
	hdac1	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (498 aa)
	birc5	Baculoviral IAP repeat-containing protein 5. (142 aa)
	atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	ccne2	G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (395 aa)
	TLR-2	Toll-like receptor 13. (572 aa)
	CCNE1	G1/S-specific cyclin-E1. (410 aa)
	ccne2-2	G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (420 aa)
	ATG7	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (664 aa)
	lck-2	Tyrosine-protein kinase. (527 aa)
	LOC106561541	TBC1 domain family member 15-like. (694 aa)
	LOC106589072	Probable histone deacetylase 1-B. (486 aa)
	LOC106605511	Nucleotide-binding oligomerization domain-containing protein 1-like. (954 aa)
	LOC106562012	G1/S-specific cyclin-E1-like isoform X1; Belongs to the cyclin family. (410 aa)
	cdd	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (166 aa)
	fyn	Tyrosine-protein kinase. (593 aa)
	igf1r	Tyrosine-protein kinase receptor. (1425 aa)
	LOC106608673	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (377 aa)
	LOC106561308	CD44 antigen-like. (470 aa)
	ccnd1	G1/S-specific cyclin-D1; Belongs to the cyclin family. (292 aa)
	RHO	Rhodopsin. (354 aa)
	LOC106607826	Cyclin-dependent kinase 1-like; Belongs to the protein kinase superfamily. (302 aa)
	atg16l1	Autophagy-related protein 16-1 isoform X1. (621 aa)
	DNM1L	Dynamin-1-like protein isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (710 aa)
	LOC106567593	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC106587118	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (581 aa)
	LOC106602722	Caspase-3-like; Belongs to the peptidase C14A family. (284 aa)
	LOC100136459	Caspase 8-like protein. (499 aa)
	LOC106581183	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	LOC106562391	LOW QUALITY PROTEIN: nucleotide-binding oligomerization domain-containing protein 2-like. (852 aa)
	LOC106570688	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (485 aa)
	rig-I	Retinoic acid-inducible gene-I. (557 aa)
	rho	Rhodopsin. (343 aa)
	LOC106567112	Tyrosine-protein kinase. (553 aa)
	mlst8	Target of rapamycin complex subunit LST8. (341 aa)
	LOC106572626	Tyrosine-protein kinase. (540 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2-like isoform X1. (587 aa)
	dnm1l	Dynamin-1-like protein isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (692 aa)
	LOC106587134	Apoptosis regulator BAX-like. (204 aa)
	LOC106579390	Nucleotide-binding oligomerization domain-containing protein 1-like. (960 aa)

Your Current Organism:

Salmo salar

NCBI taxonomy Id: 8030
Other names: Atlantic salmon, S. salar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG7	BCL2	ENSSSAP00000066660	ENSSSAP00000114628	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Apoptosis regulator Bcl-2-like.	0.605
ATG7	LOC100136459	ENSSSAP00000066660	ENSSSAP00000034747	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Caspase 8-like protein.	0.467
ATG7	LOC100380690	ENSSSAP00000066660	ENSSSAP00000114883	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily.	0.601
ATG7	LOC106581183	ENSSSAP00000066660	ENSSSAP00000038251	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Autophagy protein 5; Involved in autophagic vesicle formation.	0.969
ATG7	LOC106587118	ENSSSAP00000066660	ENSSSAP00000033997	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily.	0.601
ATG7	LOC106608673	ENSSSAP00000066660	ENSSSAP00000007484	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.608
ATG7	atg10	ENSSSAP00000066660	ENSSSAP00000059227	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Ubiquitin-like-conjugating enzyme ATG10.	0.980
ATG7	atg16l1	ENSSSAP00000066660	ENSSSAP00000015267	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Autophagy-related protein 16-1 isoform X1.	0.905
ATG7	atg5	ENSSSAP00000066660	ENSSSAP00000061660	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Autophagy protein 5; Involved in autophagic vesicle formation.	0.969
ATG7	birc5	ENSSSAP00000066660	ENSSSAP00000002455	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Baculoviral IAP repeat-containing protein 5.	0.497
ATG7	epg5	ENSSSAP00000066660	ENSSSAP00000099683	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	LOW QUALITY PROTEIN: ectopic P granules protein 5 homolog.	0.601
ATG7	mlst8	ENSSSAP00000066660	ENSSSAP00000047827	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Target of rapamycin complex subunit LST8.	0.455
ATG7	tp53	ENSSSAP00000066660	ENSSSAP00000057928	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.608
BCL2	ATG7	ENSSSAP00000114628	ENSSSAP00000066660	Apoptosis regulator Bcl-2-like.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.605
BCL2	LOC100136459	ENSSSAP00000114628	ENSSSAP00000034747	Apoptosis regulator Bcl-2-like.	Caspase 8-like protein.	0.553
BCL2	LOC106561972	ENSSSAP00000114628	ENSSSAP00000115522	Apoptosis regulator Bcl-2-like.	Apoptosis regulator BAX-like.	0.868
BCL2	LOC106581183	ENSSSAP00000114628	ENSSSAP00000038251	Apoptosis regulator Bcl-2-like.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.455
BCL2	LOC106587134	ENSSSAP00000114628	ENSSSAP00000054624	Apoptosis regulator Bcl-2-like.	Apoptosis regulator BAX-like.	0.868
BCL2	LOC106602722	ENSSSAP00000114628	ENSSSAP00000034454	Apoptosis regulator Bcl-2-like.	Caspase-3-like; Belongs to the peptidase C14A family.	0.722
BCL2	LOC106608673	ENSSSAP00000114628	ENSSSAP00000007484	Apoptosis regulator Bcl-2-like.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.888