STRINGSTRING
rfc3 rfc3 prim2 prim2 rnh2c rnh2c pold4 pold4 pold3 pold3 mcm7 mcm7 LOC106607055 LOC106607055 rfc2 rfc2 LOC106564474 LOC106564474 LOC106613703 LOC106613703 PCNA PCNA MCM5 MCM5 LOC106601920 LOC106601920 mc6zb mc6zb rnaseh1 rnaseh1 LOC106569286 LOC106569286 mcm2 mcm2 DPOD1 DPOD1 rfa1 rfa1 LOC106569474 LOC106569474 rpa2 rpa2 mcm3 mcm3 LOC106580445 LOC106580445 prim1 prim1 pole3 pole3 DNA2 DNA2 rfc5 rfc5 pole pole LOC106605109 LOC106605109 rpa3 rpa3 rfc4 rfc4 mcm4 mcm4 dpoe4 dpoe4 LOC106576077 LOC106576077 LOC106570310 LOC106570310 pold2 pold2 LOC106608109 LOC106608109 pole2 pole2 pola1 pola1 FEN1 FEN1 LOC106583719 LOC106583719 LOC106560381 LOC106560381 lig1 lig1 LOC106569128 LOC106569128
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rfc3Replication factor C subunit 3 isoform X1. (334 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (515 aa)
rnh2cRibonuclease H2 subunit C. (140 aa)
pold4DNA polymerase subunit delta-4. (125 aa)
pold3DNA polymerase delta subunit 3 isoform X1. (449 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (727 aa)
LOC106607055DNA replication licensing factor mcm5-like; Belongs to the MCM family. (525 aa)
rfc2Replication factor C subunit 2. (381 aa)
LOC106564474Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (309 aa)
LOC106613703DNA polymerase epsilon subunit 4-like. (149 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
MCM5DNA helicase; Belongs to the MCM family. (770 aa)
LOC106601920DNA polymerase delta catalytic subunit-like. (681 aa)
mc6zbDNA helicase; Belongs to the MCM family. (838 aa)
rnaseh1Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (293 aa)
LOC106569286DNA helicase; Belongs to the MCM family. (826 aa)
mcm2DNA helicase; Belongs to the MCM family. (886 aa)
DPOD1DNA polymerase. (899 aa)
rfa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
LOC106569474DNA helicase; Belongs to the MCM family. (837 aa)
rpa2Replication protein A 32 kDa subunit. (278 aa)
mcm3DNA helicase; Belongs to the MCM family. (813 aa)
LOC106580445Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (476 aa)
pole3DNA-directed DNA polymerase epsilon 3. (151 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2. (1073 aa)
rfc5Replication factor C subunit 5. (341 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2292 aa)
LOC106605109Replication protein A 32 kDa subunit-like. (278 aa)
rpa3Replication protein A3. (159 aa)
rfc4Replication factor C subunit 4 isoform X1. (361 aa)
mcm4DNA helicase; Belongs to the MCM family. (881 aa)
dpoe4DNA-directed DNA polymerase epsilon 4. (130 aa)
LOC106576077Single-stranded DNA-binding protein, mitochondrial-like isoform X1. (221 aa)
LOC106570310Replication protein A 14 kDa subunit-like. (147 aa)
pold2DNA polymerase subunit delta-2. (500 aa)
LOC106608109Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (300 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (567 aa)
pola1DNA polymerase. (1466 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (402 aa)
LOC106583719DNA helicase; Belongs to the MCM family. (921 aa)
LOC106560381DNA helicase; Belongs to the MCM family. (808 aa)
lig1DNA ligase. (1088 aa)
LOC106569128DNA helicase; Belongs to the MCM family. (892 aa)
Your Current Organism:
Salmo salar
NCBI taxonomy Id: 8030
Other names: Atlantic salmon, S. salar
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