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eme1 eme1 LOC106593073 LOC106593073 LOC106607888 LOC106607888 pold4 pold4 pold3 pold3 babam2 babam2 brcc3 brcc3 LOC106603421 LOC106603421 LOC106561293 LOC106561293 xrcc3 xrcc3 babam1 babam1 LOC106601920 LOC106601920 rad51d rad51d rad51 rad51 atm atm DPOD1 DPOD1 LOC106605995 LOC106605995 brca2 brca2 rfa1 rfa1 sem1 sem1 LOC106605998 LOC106605998 brip1 brip1 rpa2 rpa2 LOC106568011 LOC106568011 LOC106570471 LOC106570471 LOC106582297 LOC106582297 rad51c rad51c Mre11 Mre11 LOC106590185 LOC106590185 LOC106605109 LOC106605109 rpa3 rpa3 TOP3B TOP3B LOC106590210 LOC106590210 abraxas1 abraxas1 LOC106576077 LOC106576077 LOC106570310 LOC106570310 XRCC2 XRCC2 pold2 pold2 rad51b rad51b rad50 rad50 brca1 brca1 rad52 rad52 LOC106603169 LOC106603169 blm blm rad54l rad54l LOC106583485 LOC106583485
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
eme1Crossover junction endonuclease EME1 isoform X1. (564 aa)
LOC106593073Partner and localizer of BRCA2-like. (1294 aa)
LOC106607888DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
pold4DNA polymerase subunit delta-4. (125 aa)
pold3DNA polymerase delta subunit 3 isoform X1. (449 aa)
babam2BRCA1-A complex subunit BRE. (454 aa)
brcc3Lys-63-specific deubiquitinase BRCC36; Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the rnf8-dependent ubiquitination at double- [...] (260 aa)
LOC106603421BRCA1-A complex subunit RAP80-like. (1105 aa)
LOC106561293Synaptonemal complex protein 3-like. (259 aa)
xrcc3DNA repair protein XRCC3. (371 aa)
babam1BRISC and BRCA1-A complex member 1. (373 aa)
LOC106601920DNA polymerase delta catalytic subunit-like. (681 aa)
rad51dDNA repair protein RAD51 homolog 4. (336 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa)
atmNon-specific serine/threonine protein kinase. (3172 aa)
DPOD1DNA polymerase. (899 aa)
LOC106605995Nibrin-like isoform X1. (635 aa)
brca2Breast cancer type 2 susceptibility protein isoform X5. (2826 aa)
rfa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
sem126S proteasome complex subunit DSS1. (71 aa)
LOC106605998Nibrin-like. (442 aa)
brip1Fanconi anemia group J protein. (1530 aa)
rpa2Replication protein A 32 kDa subunit. (278 aa)
LOC106568011BRCA1-A complex subunit RAP80-like isoform X1. (1164 aa)
LOC10657047126S proteasome complex subunit DSS1-like. (70 aa)
LOC106582297BRCA1-associated RING domain protein 1-like isoform X1. (847 aa)
rad51cDNA repair protein RAD51 homolog 3. (400 aa)
Mre11MRE11 homolog, double strand break repair nuclease. (452 aa)
LOC106590185DNA topoisomerase 2-binding protein 1-A-like. (1534 aa)
LOC106605109Replication protein A 32 kDa subunit-like. (278 aa)
rpa3Replication protein A3. (159 aa)
TOP3BDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1044 aa)
LOC106590210DNA endonuclease RBBP8-like. (723 aa)
abraxas1BRCA1-A complex subunit Abraxas 1; Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of brca1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX [...] (404 aa)
LOC106576077Single-stranded DNA-binding protein, mitochondrial-like isoform X1. (221 aa)
LOC106570310Replication protein A 14 kDa subunit-like. (147 aa)
XRCC2DNA repair protein XRCC2-like. (307 aa)
pold2DNA polymerase subunit delta-2. (500 aa)
rad51bDNA repair protein RAD51 homolog 2 isoform X1. (418 aa)
rad50DNA repair protein RAD50. (1316 aa)
brca1Breast cancer type 1 susceptibility protein isoform X2. (1567 aa)
rad52DNA repair protein RAD52 homolog. (448 aa)
LOC106603169Lys-63-specific deubiquitinase BRCC36-like isoform X1. (260 aa)
blmBloom syndrome protein isoform X1. (1471 aa)
rad54lDNA repair and recombination protein RAD54-like. (742 aa)
LOC106583485Synaptonemal complex protein 3-like isoform X1. (235 aa)
Your Current Organism:
Salmo salar
NCBI taxonomy Id: 8030
Other names: Atlantic salmon, S. salar
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