(43 nodes) Mixed, incl. RIPK1-mediated regulated necrosis, and IRAK2 mediated activation of TAK1 complex network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105928876	Fas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family. (269 aa)
	LOC105922073	TNF superfamily member 10; Belongs to the tumor necrosis factor family. (279 aa)
	LOC105921964	Protein kinase domain-containing protein. (452 aa)
	LOC105931292	X-linked inhibitor of apoptosis. (402 aa)
	LOC105919032	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (481 aa)
	LOC105932356	MALT paracaspase 3. (653 aa)
	traf2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
	malt1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1. (830 aa)
	LOC105926683	RanBP-type and C3HC4-type zinc finger-containing protein 1. (733 aa)
	tab3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (606 aa)
	ENSFHEP00000006195	Uncharacterized protein; Belongs to the peptidase C14A family. (284 aa)
	ikbkb	Inhibitor of nuclear factor kappa B kinase subunit beta. (743 aa)
	cflar	Uncharacterized protein; Belongs to the peptidase C14A family. (452 aa)
	card11	Caspase recruitment domain-containing protein 11. (1152 aa)
	tab2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (744 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
	ripk1	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like. (676 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (576 aa)
	LOC105935349	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (292 aa)
	LOC105930243	Uncharacterized protein; Belongs to the peptidase C14A family. (499 aa)
	LOC105930248	Caspase-8; Belongs to the peptidase C14A family. (385 aa)
	LOC105928324	Tumor necrosis factor receptor superfamily, member a. (447 aa)
	ENSFHEP00000020243	Protein kinase domain-containing protein. (116 aa)
	LOC105939294	Tumor necrosis factor receptor superfamily, member 1B. (454 aa)
	LOC105915531	Uncharacterized protein. (390 aa)
	LOC105940240	Uncharacterized protein. (314 aa)
	LOC105938713	Receptor-interacting serine-threonine kinase 3. (436 aa)
	LOC105915564	TNF receptor-associated factor. (476 aa)
	plekhg5	Pleckstrin homology domain containing, family G (with RhoGef domain) member 5b. (1149 aa)
	rnf31	Ring finger protein 31. (987 aa)
	LOC105936849	Mucosa-associated lymphoid tissue lymphoma translocation protein 1. (823 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (765 aa)
	LOC105937601	Mitogen-activated protein kinase kinase kinase 14a. (869 aa)
	ENSFHEP00000026200	TGF-beta activated kinase 1/MAP3K7 binding protein 1. (436 aa)
	tradd	Tnfrsf1a-associated via death domain. (292 aa)
	ikbkg	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (584 aa)
	tnfrsf1a	Tumor necrosis factor receptor superfamily, member 1a. (385 aa)
	sharpin	SHANK-associated RH domain interacting protein. (436 aa)
	LOC105935999	RanBP-type and C3HC4-type zinc finger-containing protein 1. (510 aa)
	LOC105934231	Protein kinase domain-containing protein. (674 aa)
	LOC105919183	Receptor-interacting serine-threonine kinase 3; Belongs to the protein kinase superfamily. (498 aa)
	fadd	Uncharacterized protein. (195 aa)
	LOC105933655	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHUK	ENSFHEP00000020243	ENSFHEP00000023665	ENSFHEP00000020243	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase domain-containing protein.	0.947
CHUK	ENSFHEP00000026200	ENSFHEP00000023665	ENSFHEP00000026200	Component of inhibitor of nuclear factor kappa B kinase complex.	TGF-beta activated kinase 1/MAP3K7 binding protein 1.	0.974
CHUK	LOC105915564	ENSFHEP00000023665	ENSFHEP00000022394	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor.	0.686
CHUK	LOC105919032	ENSFHEP00000023665	ENSFHEP00000001672	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.970
CHUK	LOC105919183	ENSFHEP00000023665	ENSFHEP00000033309	Component of inhibitor of nuclear factor kappa B kinase complex.	Receptor-interacting serine-threonine kinase 3; Belongs to the protein kinase superfamily.	0.533
CHUK	LOC105921964	ENSFHEP00000023665	ENSFHEP00000000511	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase domain-containing protein.	0.404
CHUK	LOC105926683	ENSFHEP00000023665	ENSFHEP00000003366	Component of inhibitor of nuclear factor kappa B kinase complex.	RanBP-type and C3HC4-type zinc finger-containing protein 1.	0.589
CHUK	LOC105931292	ENSFHEP00000023665	ENSFHEP00000001245	Component of inhibitor of nuclear factor kappa B kinase complex.	X-linked inhibitor of apoptosis.	0.672
CHUK	LOC105932356	ENSFHEP00000023665	ENSFHEP00000001732	Component of inhibitor of nuclear factor kappa B kinase complex.	MALT paracaspase 3.	0.927
CHUK	LOC105933655	ENSFHEP00000023665	ENSFHEP00000034560	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.686
CHUK	LOC105934231	ENSFHEP00000023665	ENSFHEP00000032738	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase domain-containing protein.	0.828
CHUK	LOC105935999	ENSFHEP00000023665	ENSFHEP00000031188	Component of inhibitor of nuclear factor kappa B kinase complex.	RanBP-type and C3HC4-type zinc finger-containing protein 1.	0.589
CHUK	LOC105936849	ENSFHEP00000023665	ENSFHEP00000023309	Component of inhibitor of nuclear factor kappa B kinase complex.	Mucosa-associated lymphoid tissue lymphoma translocation protein 1.	0.950
CHUK	LOC105937601	ENSFHEP00000023665	ENSFHEP00000024289	Component of inhibitor of nuclear factor kappa B kinase complex.	Mitogen-activated protein kinase kinase kinase 14a.	0.981
CHUK	LOC105938713	ENSFHEP00000023665	ENSFHEP00000022143	Component of inhibitor of nuclear factor kappa B kinase complex.	Receptor-interacting serine-threonine kinase 3.	0.585
CHUK	LOC105940240	ENSFHEP00000023665	ENSFHEP00000021980	Component of inhibitor of nuclear factor kappa B kinase complex.	Uncharacterized protein.	0.403
CHUK	card11	ENSFHEP00000023665	ENSFHEP00000009241	Component of inhibitor of nuclear factor kappa B kinase complex.	Caspase recruitment domain-containing protein 11.	0.730
CHUK	fadd	ENSFHEP00000023665	ENSFHEP00000033591	Component of inhibitor of nuclear factor kappa B kinase complex.	Uncharacterized protein.	0.620
CHUK	ikbkb	ENSFHEP00000023665	ENSFHEP00000006306	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.952
CHUK	ikbkg	ENSFHEP00000023665	ENSFHEP00000028098	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.988