(12 nodes) FasL/ CD95L signaling, and Amyloid fibril formation network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105928876	Fas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family. (269 aa)
	LOC105921964	Protein kinase domain-containing protein. (452 aa)
	ENSFHEP00000006195	Uncharacterized protein; Belongs to the peptidase C14A family. (284 aa)
	cflar	Uncharacterized protein; Belongs to the peptidase C14A family. (452 aa)
	ripk1	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like. (676 aa)
	LOC105930243	Uncharacterized protein; Belongs to the peptidase C14A family. (499 aa)
	LOC105930248	Caspase-8; Belongs to the peptidase C14A family. (385 aa)
	LOC105940240	Uncharacterized protein. (314 aa)
	LOC105938713	Receptor-interacting serine-threonine kinase 3. (436 aa)
	tradd	Tnfrsf1a-associated via death domain. (292 aa)
	LOC105919183	Receptor-interacting serine-threonine kinase 3; Belongs to the protein kinase superfamily. (498 aa)
	fadd	Uncharacterized protein. (195 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000006195	LOC105919183	ENSFHEP00000006195	ENSFHEP00000033309	Uncharacterized protein; Belongs to the peptidase C14A family.	Receptor-interacting serine-threonine kinase 3; Belongs to the protein kinase superfamily.	0.981
ENSFHEP00000006195	LOC105921964	ENSFHEP00000006195	ENSFHEP00000000511	Uncharacterized protein; Belongs to the peptidase C14A family.	Protein kinase domain-containing protein.	0.599
ENSFHEP00000006195	LOC105928876	ENSFHEP00000006195	ENSFHEP00000000214	Uncharacterized protein; Belongs to the peptidase C14A family.	Fas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family.	0.910
ENSFHEP00000006195	LOC105930243	ENSFHEP00000006195	ENSFHEP00000017119	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.924
ENSFHEP00000006195	LOC105930248	ENSFHEP00000006195	ENSFHEP00000017146	Uncharacterized protein; Belongs to the peptidase C14A family.	Caspase-8; Belongs to the peptidase C14A family.	0.921
ENSFHEP00000006195	LOC105938713	ENSFHEP00000006195	ENSFHEP00000022143	Uncharacterized protein; Belongs to the peptidase C14A family.	Receptor-interacting serine-threonine kinase 3.	0.981
ENSFHEP00000006195	LOC105940240	ENSFHEP00000006195	ENSFHEP00000021980	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.961
ENSFHEP00000006195	cflar	ENSFHEP00000006195	ENSFHEP00000007934	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.993
ENSFHEP00000006195	fadd	ENSFHEP00000006195	ENSFHEP00000033591	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.995
ENSFHEP00000006195	ripk1	ENSFHEP00000006195	ENSFHEP00000013323	Uncharacterized protein; Belongs to the peptidase C14A family.	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	0.990
ENSFHEP00000006195	tradd	ENSFHEP00000006195	ENSFHEP00000027810	Uncharacterized protein; Belongs to the peptidase C14A family.	Tnfrsf1a-associated via death domain.	0.988
LOC105919183	ENSFHEP00000006195	ENSFHEP00000033309	ENSFHEP00000006195	Receptor-interacting serine-threonine kinase 3; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.981
LOC105919183	LOC105921964	ENSFHEP00000033309	ENSFHEP00000000511	Receptor-interacting serine-threonine kinase 3; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.996
LOC105919183	LOC105928876	ENSFHEP00000033309	ENSFHEP00000000214	Receptor-interacting serine-threonine kinase 3; Belongs to the protein kinase superfamily.	Fas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family.	0.481
LOC105919183	LOC105930243	ENSFHEP00000033309	ENSFHEP00000017119	Receptor-interacting serine-threonine kinase 3; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.967
LOC105919183	LOC105930248	ENSFHEP00000033309	ENSFHEP00000017146	Receptor-interacting serine-threonine kinase 3; Belongs to the protein kinase superfamily.	Caspase-8; Belongs to the peptidase C14A family.	0.943
LOC105919183	LOC105938713	ENSFHEP00000033309	ENSFHEP00000022143	Receptor-interacting serine-threonine kinase 3; Belongs to the protein kinase superfamily.	Receptor-interacting serine-threonine kinase 3.	0.766
LOC105919183	LOC105940240	ENSFHEP00000033309	ENSFHEP00000021980	Receptor-interacting serine-threonine kinase 3; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.627
LOC105919183	cflar	ENSFHEP00000033309	ENSFHEP00000007934	Receptor-interacting serine-threonine kinase 3; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.674
LOC105919183	fadd	ENSFHEP00000033309	ENSFHEP00000033591	Receptor-interacting serine-threonine kinase 3; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.986