(64 nodes) Histone deacetylase complex, and HDACs deacetylate histones network (Fundulus heteroclitus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSFHEP00000000257	Uncharacterized protein. (1131 aa)
	ncor2	Nuclear receptor corepressor 2. (2295 aa)
	mta1	Metastasis associated 1. (704 aa)
	GPS2	Uncharacterized protein. (129 aa)
	LOC105934097	Chromodomain helicase DNA binding protein 4a. (1765 aa)
	ENSFHEP00000001303	Uncharacterized protein. (1401 aa)
	LOC105934609	Uncharacterized protein. (246 aa)
	camk4	Si:ch73-60h1.1. (472 aa)
	arid4b	Translocase of outer mitochondrial membrane 20. (1295 aa)
	phf12	PHD finger protein 12b. (1017 aa)
	LOC105930618	BRMS1 like transcriptional repressor b. (255 aa)
	suds3	SDS3 homolog, SIN3A corepressor complex component. (318 aa)
	sin3b	SIN3 transcription regulator family member B. (1265 aa)
	rcor2	REST corepressor 2. (493 aa)
	LOC105935657	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa)
	ncor1	Nuclear receptor corepressor 1. (2343 aa)
	ENSFHEP00000005668	BAH domain-containing protein. (89 aa)
	LOC105938601	Calcium/calmodulin-dependent protein kinase 1Db; Belongs to the protein kinase superfamily. (412 aa)
	sall3	Spalt-like transcription factor 3a. (1256 aa)
	hdac5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1134 aa)
	hdac7	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1043 aa)
	rcor3	REST corepressor 3. (550 aa)
	brms1	BRMS1 transcriptional repressor and anoikis regulator. (274 aa)
	LOC105938962	Methyl-CpG binding domain protein 3a. (276 aa)
	hmg20a	High mobility group 20A. (291 aa)
	hmg20b	High mobility group 20B. (294 aa)
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (515 aa)
	gatad1	GATA zinc finger domain containing 1. (264 aa)
	LOC105936597	Methyl-CpG binding domain protein 2. (265 aa)
	LOC105926306	Histone deacetylase 9b. (559 aa)
	ENSFHEP00000015378	Uncharacterized protein. (369 aa)
	ENSFHEP00000015398	PHD domain-containing protein. (74 aa)
	ing1	Inhibitor of growth protein. (350 aa)
	ENSFHEP00000015952	Histone deacetylase 6. (462 aa)
	sin3a	SIN3 transcription regulator family member Aa. (1285 aa)
	hdac10	Histone deacetylase 10. (683 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1101 aa)
	phf21a	PHD finger protein 21Ab. (840 aa)
	sap30l	Sap30-like. (178 aa)
	hdac8	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (401 aa)
	LOC105933639	Transducin beta like 1 X-linked. (513 aa)
	ENSFHEP00000018807	GATA zinc finger domain containing 2B. (639 aa)
	brms1l	Breast cancer metastasis-suppressor 1-like protein. (263 aa)
	LOC105930167	SIN3 transcription regulator family member Ab. (1224 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
	emsy	EMSY transcriptional repressor, BRCA2 interacting. (1263 aa)
	mta2	Metastasis associated 1 family, member 2. (640 aa)
	ENSFHEP00000021531	MBD domain-containing protein. (133 aa)
	LOC105934592	Uncharacterized protein. (745 aa)
	chd5	Uncharacterized protein. (1743 aa)
	rcor1	REST corepressor 1. (351 aa)
	LOC105931735	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (936 aa)
	ENSFHEP00000027779	Histone deacetylase 12. (237 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (834 aa)
	hdac11	Histone deacetylase 11. (357 aa)
	chd4	Chromodomain helicase DNA binding protein 4b. (1756 aa)
	wdr73	WD_REPEATS_REGION domain-containing protein. (329 aa)
	LOC105925303	Transducin (beta)-like 1 X-linked receptor 1b. (511 aa)
	ENSFHEP00000031225	CHDCT2 domain-containing protein. (284 aa)
	LOC105919250	MBD domain-containing protein. (881 aa)
	rest	RE1-silencing transcription factor. (906 aa)
	LOC105927971	Mortality factor 4 1-like protein. (323 aa)
	gatad2a	GATA zinc finger domain containing 2Ab. (641 aa)
	PHF21B	PHD finger protein 21B. (573 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000000257	ENSFHEP00000001303	ENSFHEP00000000257	ENSFHEP00000001303	Uncharacterized protein.	Uncharacterized protein.	0.603
ENSFHEP00000000257	ENSFHEP00000005668	ENSFHEP00000000257	ENSFHEP00000005668	Uncharacterized protein.	BAH domain-containing protein.	0.805
ENSFHEP00000000257	ENSFHEP00000015378	ENSFHEP00000000257	ENSFHEP00000015378	Uncharacterized protein.	Uncharacterized protein.	0.725
ENSFHEP00000000257	ENSFHEP00000015398	ENSFHEP00000000257	ENSFHEP00000015398	Uncharacterized protein.	PHD domain-containing protein.	0.725
ENSFHEP00000000257	ENSFHEP00000015952	ENSFHEP00000000257	ENSFHEP00000015952	Uncharacterized protein.	Histone deacetylase 6.	0.656
ENSFHEP00000000257	ENSFHEP00000021531	ENSFHEP00000000257	ENSFHEP00000021531	Uncharacterized protein.	MBD domain-containing protein.	0.681
ENSFHEP00000000257	ENSFHEP00000027779	ENSFHEP00000000257	ENSFHEP00000027779	Uncharacterized protein.	Histone deacetylase 12.	0.656
ENSFHEP00000000257	ENSFHEP00000031225	ENSFHEP00000000257	ENSFHEP00000031225	Uncharacterized protein.	CHDCT2 domain-containing protein.	0.725
ENSFHEP00000000257	HDAC3	ENSFHEP00000000257	ENSFHEP00000020300	Uncharacterized protein.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.851
ENSFHEP00000000257	HDAC4	ENSFHEP00000000257	ENSFHEP00000016860	Uncharacterized protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.656
ENSFHEP00000000257	LOC105919250	ENSFHEP00000000257	ENSFHEP00000031715	Uncharacterized protein.	MBD domain-containing protein.	0.681
ENSFHEP00000000257	LOC105926306	ENSFHEP00000000257	ENSFHEP00000013238	Uncharacterized protein.	Histone deacetylase 9b.	0.656
ENSFHEP00000000257	LOC105930618	ENSFHEP00000000257	ENSFHEP00000003937	Uncharacterized protein.	BRMS1 like transcriptional repressor b.	0.520
ENSFHEP00000000257	LOC105931735	ENSFHEP00000000257	ENSFHEP00000024928	Uncharacterized protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.656
ENSFHEP00000000257	LOC105934097	ENSFHEP00000000257	ENSFHEP00000001244	Uncharacterized protein.	Chromodomain helicase DNA binding protein 4a.	0.725
ENSFHEP00000000257	LOC105934609	ENSFHEP00000000257	ENSFHEP00000001534	Uncharacterized protein.	Uncharacterized protein.	0.681
ENSFHEP00000000257	LOC105935657	ENSFHEP00000000257	ENSFHEP00000005106	Uncharacterized protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.656
ENSFHEP00000000257	LOC105936597	ENSFHEP00000000257	ENSFHEP00000012906	Uncharacterized protein.	Methyl-CpG binding domain protein 2.	0.681
ENSFHEP00000000257	LOC105938962	ENSFHEP00000000257	ENSFHEP00000011133	Uncharacterized protein.	Methyl-CpG binding domain protein 3a.	0.681
ENSFHEP00000000257	PHF21B	ENSFHEP00000000257	ENSFHEP00000035192	Uncharacterized protein.	PHD finger protein 21B.	0.725