(18 nodes) TGF-beta propeptide, and Transforming growth factor beta receptor activity, type I network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105915540	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (732 aa)
	LOC105920199	TGF_BETA_2 domain-containing protein. (446 aa)
	LOC105939150	Bone morphogenetic protein 16. (476 aa)
	LOC105931003	Anti-dorsalizing morphogenic protein. (380 aa)
	bmpr1b	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (541 aa)
	LOC105930843	Growth differentiation factor 2. (422 aa)
	bmp4	Bone morphogenetic protein 4. (399 aa)
	bmp2	Bone morphogenetic protein 2b. (419 aa)
	chrd	Chordin; Belongs to the chordin family. (1031 aa)
	LOC105928977	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (527 aa)
	gdf5	Growth differentiation factor 5. (487 aa)
	acvr2a	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
	bmp8a	Bone morphogenetic protein 8a. (435 aa)
	LOC105939051	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
	bmpr1a	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (525 aa)
	LOC105930844	TGF_BETA_2 domain-containing protein. (390 aa)
	LOC105930794	Bone morphogenetic protein 10, like. (458 aa)
	ENSFHEP00000033245	Activin_recp domain-containing protein. (189 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000033245	LOC105915540	ENSFHEP00000033245	ENSFHEP00000002575	Activin_recp domain-containing protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.961
ENSFHEP00000033245	LOC105920199	ENSFHEP00000033245	ENSFHEP00000004514	Activin_recp domain-containing protein.	TGF_BETA_2 domain-containing protein.	0.978
ENSFHEP00000033245	LOC105928977	ENSFHEP00000033245	ENSFHEP00000021217	Activin_recp domain-containing protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.656
ENSFHEP00000033245	LOC105930794	ENSFHEP00000033245	ENSFHEP00000032879	Activin_recp domain-containing protein.	Bone morphogenetic protein 10, like.	0.824
ENSFHEP00000033245	LOC105930843	ENSFHEP00000033245	ENSFHEP00000015735	Activin_recp domain-containing protein.	Growth differentiation factor 2.	0.821
ENSFHEP00000033245	LOC105930844	ENSFHEP00000033245	ENSFHEP00000031581	Activin_recp domain-containing protein.	TGF_BETA_2 domain-containing protein.	0.947
ENSFHEP00000033245	LOC105931003	ENSFHEP00000033245	ENSFHEP00000008993	Activin_recp domain-containing protein.	Anti-dorsalizing morphogenic protein.	0.968
ENSFHEP00000033245	LOC105939051	ENSFHEP00000033245	ENSFHEP00000026129	Activin_recp domain-containing protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.937
ENSFHEP00000033245	LOC105939150	ENSFHEP00000033245	ENSFHEP00000005655	Activin_recp domain-containing protein.	Bone morphogenetic protein 16.	0.985
ENSFHEP00000033245	acvr2a	ENSFHEP00000033245	ENSFHEP00000023473	Activin_recp domain-containing protein.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.973
ENSFHEP00000033245	bmp2	ENSFHEP00000033245	ENSFHEP00000018050	Activin_recp domain-containing protein.	Bone morphogenetic protein 2b.	0.986
ENSFHEP00000033245	bmp4	ENSFHEP00000033245	ENSFHEP00000017972	Activin_recp domain-containing protein.	Bone morphogenetic protein 4.	0.989
ENSFHEP00000033245	bmp8a	ENSFHEP00000033245	ENSFHEP00000025641	Activin_recp domain-containing protein.	Bone morphogenetic protein 8a.	0.936
ENSFHEP00000033245	bmpr1a	ENSFHEP00000033245	ENSFHEP00000031413	Activin_recp domain-containing protein.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.575
ENSFHEP00000033245	gdf5	ENSFHEP00000033245	ENSFHEP00000022785	Activin_recp domain-containing protein.	Growth differentiation factor 5.	0.984
LOC105915540	ENSFHEP00000033245	ENSFHEP00000002575	ENSFHEP00000033245	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Activin_recp domain-containing protein.	0.961
LOC105915540	LOC105920199	ENSFHEP00000002575	ENSFHEP00000004514	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	TGF_BETA_2 domain-containing protein.	0.961
LOC105915540	LOC105928977	ENSFHEP00000002575	ENSFHEP00000021217	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.966
LOC105915540	LOC105930794	ENSFHEP00000002575	ENSFHEP00000032879	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 10, like.	0.980
LOC105915540	LOC105930843	ENSFHEP00000002575	ENSFHEP00000015735	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Growth differentiation factor 2.	0.968