(81 nodes) Wnt signaling pathway, and Ligand-receptor interactions network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	wnt10b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	dhh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (447 aa)
	ror1	Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (954 aa)
	FZD7	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (518 aa)
	LOC105940217	Dickkopf WNT signaling pathway inhibitor 1a. (261 aa)
	sfrp5	Secreted frizzled-related protein 5. (318 aa)
	LOC105938539	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	LOC105932296	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	LOC105918991	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (256 aa)
	LOC105923386	Secreted frizzled-related protein 2 like. (342 aa)
	fzd4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
	ENSFHEP00000003609	Growth arrest-specific 1a. (259 aa)
	LOC105937522	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	dkk2	Dickkopf WNT signaling pathway inhibitor 2. (242 aa)
	LOC105936264	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
	wnt10a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
	wnt6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
	ENSFHEP00000006636	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (545 aa)
	LOC105917773	Uncharacterized protein. (941 aa)
	LOC105931887	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (434 aa)
	LOC105933812	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	ryk	Receptor like tyrosine kinase. (653 aa)
	LOC105927030	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (311 aa)
	ENSFHEP00000009221	Uncharacterized protein. (268 aa)
	LOC105917077	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	ENSFHEP00000010347	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (340 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (318 aa)
	ENSFHEP00000010461	Uncharacterized protein. (259 aa)
	LOC105930965	Si:dkey-88l16.3. (1260 aa)
	sost	Sclerostin. (226 aa)
	LOC105930947	Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa)
	LOC105919329	Dickkopf-related protein 2. (288 aa)
	LOC105930358	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (577 aa)
	gpc3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (541 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	ptch1	Patched 1. (1417 aa)
	ENSFHEP00000016173	Uncharacterized protein. (208 aa)
	LOC105915760	Notum, palmitoleoyl-protein carboxylesterase. (519 aa)
	LOC105935883	Uncharacterized protein. (251 aa)
	ENSFHEP00000017921	Growth arrest-specific 1b. (243 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (812 aa)
	porcn	Porcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (419 aa)
	wnt8b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
	ptch2	Patched 2. (1299 aa)
	LOC105937015	Low density lipoprotein receptor-related protein 1Aa. (4383 aa)
	lrp2	Low density lipoprotein receptor-related protein 2a. (4006 aa)
	fzd3	Frizzled class receptor 3a; Belongs to the G-protein coupled receptor Fz/Smo family. (682 aa)
	sfrp1	Secreted frizzled-related protein 1a. (305 aa)
	LOC105927384	Sizzled. (293 aa)
	fzd10	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (597 aa)
	LOC105936964	Glypican 5b; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (624 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (335 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	ENSFHEP00000022272	Frizzled class receptor 9b; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
	LOC105920957	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (388 aa)
	hhip	Hedgehog interacting protein. (739 aa)
	notum	Notum, palmitoleoyl-protein carboxylesterase a. (500 aa)
	fzd6	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (689 aa)
	frzb	Frizzled related protein. (313 aa)
	LOC105917074	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (329 aa)
	LOC105936610	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. (334 aa)
	lrp6	Low density lipoprotein receptor-related protein 6. (784 aa)
	ENSFHEP00000027841	Uncharacterized protein. (221 aa)
	wnt16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	ENSFHEP00000028343	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (617 aa)
	LOC105931560	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa)
	LOC105916426	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	lrp5	Low density lipoprotein receptor-related protein 5. (1600 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	LOC105939417	Low density lipoprotein receptor-related protein 2b. (4220 aa)
	LOC105931441	Notum pectinacetylesterase 2. (358 aa)
	LOC105935995	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (379 aa)
	boc	BOC cell adhesion associated, oncogene regulated. (863 aa)
	LOC105919247	Wnt ligand secretion mediator. (491 aa)
	ENSFHEP00000032373	Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (579 aa)
	LOC105916516	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	FZD3	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (719 aa)
	LOC105935872	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	cdon	Cell adhesion associated, oncogene regulated. (1094 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000003609	ENSFHEP00000009221	ENSFHEP00000003609	ENSFHEP00000009221	Growth arrest-specific 1a.	Uncharacterized protein.	0.950
ENSFHEP00000003609	ENSFHEP00000010461	ENSFHEP00000003609	ENSFHEP00000010461	Growth arrest-specific 1a.	Uncharacterized protein.	0.901
ENSFHEP00000003609	ENSFHEP00000017921	ENSFHEP00000003609	ENSFHEP00000017921	Growth arrest-specific 1a.	Growth arrest-specific 1b.	0.908
ENSFHEP00000003609	ENSFHEP00000027841	ENSFHEP00000003609	ENSFHEP00000027841	Growth arrest-specific 1a.	Uncharacterized protein.	0.475
ENSFHEP00000003609	LOC105916426	ENSFHEP00000003609	ENSFHEP00000029057	Growth arrest-specific 1a.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.952
ENSFHEP00000003609	LOC105930965	ENSFHEP00000003609	ENSFHEP00000010508	Growth arrest-specific 1a.	Si:dkey-88l16.3.	0.901
ENSFHEP00000003609	LOC105931887	ENSFHEP00000003609	ENSFHEP00000007157	Growth arrest-specific 1a.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.962
ENSFHEP00000003609	LOC105937015	ENSFHEP00000003609	ENSFHEP00000020134	Growth arrest-specific 1a.	Low density lipoprotein receptor-related protein 1Aa.	0.475
ENSFHEP00000003609	LOC105939417	ENSFHEP00000003609	ENSFHEP00000030700	Growth arrest-specific 1a.	Low density lipoprotein receptor-related protein 2b.	0.929
ENSFHEP00000003609	boc	ENSFHEP00000003609	ENSFHEP00000031259	Growth arrest-specific 1a.	BOC cell adhesion associated, oncogene regulated.	0.967
ENSFHEP00000003609	cdon	ENSFHEP00000003609	ENSFHEP00000033708	Growth arrest-specific 1a.	Cell adhesion associated, oncogene regulated.	0.971
ENSFHEP00000003609	dhh	ENSFHEP00000003609	ENSFHEP00000000080	Growth arrest-specific 1a.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.961
ENSFHEP00000003609	lrp2	ENSFHEP00000003609	ENSFHEP00000020679	Growth arrest-specific 1a.	Low density lipoprotein receptor-related protein 2a.	0.956
ENSFHEP00000003609	lrp5	ENSFHEP00000003609	ENSFHEP00000029110	Growth arrest-specific 1a.	Low density lipoprotein receptor-related protein 5.	0.475
ENSFHEP00000003609	lrp6	ENSFHEP00000003609	ENSFHEP00000027797	Growth arrest-specific 1a.	Low density lipoprotein receptor-related protein 6.	0.475
ENSFHEP00000003609	ptch1	ENSFHEP00000003609	ENSFHEP00000016159	Growth arrest-specific 1a.	Patched 1.	0.967
ENSFHEP00000003609	ptch2	ENSFHEP00000003609	ENSFHEP00000020070	Growth arrest-specific 1a.	Patched 2.	0.971
ENSFHEP00000003609	shh	ENSFHEP00000003609	ENSFHEP00000014527	Growth arrest-specific 1a.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.963
ENSFHEP00000003609	smo	ENSFHEP00000003609	ENSFHEP00000018258	Growth arrest-specific 1a.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.503
ENSFHEP00000006636	ENSFHEP00000010347	ENSFHEP00000006636	ENSFHEP00000010347	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.947