(28 nodes) Regulation of myosin-light-chain-phosphatase activity, and RHO GTPases activate PAKs network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105921309	Protein phosphatase 1 regulatory subunit. (708 aa)
	LOC105932774	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (333 aa)
	LOC105916101	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (181 aa)
	ENSFHEP00000010181	Protein kinase domain-containing protein. (144 aa)
	ENSFHEP00000010423	Formin homology 2 domain containing 1. (628 aa)
	ppp1r16b	Protein phosphatase 1, regulatory subunit 16B. (552 aa)
	lrrn1	Leucine rich repeat neuronal 1. (715 aa)
	LOC105939886	ANK_REP_REGION domain-containing protein. (232 aa)
	tecpr1	Tectonin beta-propeller repeat-containing protein 1. (1226 aa)
	LOC105925621	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (388 aa)
	ENSFHEP00000019655	Uncharacterized protein; Belongs to the protein kinase superfamily. (385 aa)
	ENSFHEP00000019697	Rho_Binding domain-containing protein. (183 aa)
	ENSFHEP00000019719	Phorbol-ester/DAG-type domain-containing protein. (139 aa)
	nr2c2ap	Nuclear receptor 2C2-associated protein. (173 aa)
	LOC105915609	Zgc:113162. (370 aa)
	ppp1r27	Protein phosphatase 1, regulatory subunit 27b. (167 aa)
	ROCK1	Rho associated coiled-coil containing protein kinase 1. (521 aa)
	ppp1r16a	Phosphatase 1 regulatory inhibitor subunit 16B. (573 aa)
	LOC105917253	ANK_REP_REGION domain-containing protein. (685 aa)
	ENSFHEP00000023599	Uncharacterized protein. (124 aa)
	LOC105928575	PRKG1_interact domain-containing protein. (210 aa)
	ENSFHEP00000026069	Rho-associated, coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. (419 aa)
	cdc42bpb	CDC42 binding protein kinase beta (DMPK-like). (1238 aa)
	LOC105928031	Protein phosphatase 1 regulatory subunit 12B. (242 aa)
	LOC105930740	Rho-associated, coiled-coil containing protein kinase 2b; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1397 aa)
	ppp1r12a	Protein phosphatase 1 regulatory subunit. (1073 aa)
	LOC105925566	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
	cdc42bpa	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1690 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000010181	ENSFHEP00000010423	ENSFHEP00000010181	ENSFHEP00000010423	Protein kinase domain-containing protein.	Formin homology 2 domain containing 1.	0.448
ENSFHEP00000010181	LOC105915609	ENSFHEP00000010181	ENSFHEP00000020514	Protein kinase domain-containing protein.	Zgc:113162.	0.569
ENSFHEP00000010181	LOC105916101	ENSFHEP00000010181	ENSFHEP00000008554	Protein kinase domain-containing protein.	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	0.481
ENSFHEP00000010181	LOC105917253	ENSFHEP00000010181	ENSFHEP00000023493	Protein kinase domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.538
ENSFHEP00000010181	LOC105921309	ENSFHEP00000010181	ENSFHEP00000003778	Protein kinase domain-containing protein.	Protein phosphatase 1 regulatory subunit.	0.538
ENSFHEP00000010181	LOC105925566	ENSFHEP00000010181	ENSFHEP00000034425	Protein kinase domain-containing protein.	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	0.481
ENSFHEP00000010181	LOC105925621	ENSFHEP00000010181	ENSFHEP00000017904	Protein kinase domain-containing protein.	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	0.481
ENSFHEP00000010181	LOC105928031	ENSFHEP00000010181	ENSFHEP00000031308	Protein kinase domain-containing protein.	Protein phosphatase 1 regulatory subunit 12B.	0.538
ENSFHEP00000010181	LOC105928575	ENSFHEP00000010181	ENSFHEP00000026024	Protein kinase domain-containing protein.	PRKG1_interact domain-containing protein.	0.538
ENSFHEP00000010181	LOC105932774	ENSFHEP00000010181	ENSFHEP00000004570	Protein kinase domain-containing protein.	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	0.481
ENSFHEP00000010181	LOC105939886	ENSFHEP00000010181	ENSFHEP00000017630	Protein kinase domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.487
ENSFHEP00000010181	ROCK1	ENSFHEP00000010181	ENSFHEP00000022815	Protein kinase domain-containing protein.	Rho associated coiled-coil containing protein kinase 1.	0.663
ENSFHEP00000010181	cdc42bpb	ENSFHEP00000010181	ENSFHEP00000027794	Protein kinase domain-containing protein.	CDC42 binding protein kinase beta (DMPK-like).	0.899
ENSFHEP00000010181	ppp1r12a	ENSFHEP00000010181	ENSFHEP00000033978	Protein kinase domain-containing protein.	Protein phosphatase 1 regulatory subunit.	0.538
ENSFHEP00000010181	ppp1r16a	ENSFHEP00000010181	ENSFHEP00000023207	Protein kinase domain-containing protein.	Phosphatase 1 regulatory inhibitor subunit 16B.	0.487
ENSFHEP00000010181	ppp1r16b	ENSFHEP00000010181	ENSFHEP00000014662	Protein kinase domain-containing protein.	Protein phosphatase 1, regulatory subunit 16B.	0.487
ENSFHEP00000010181	ppp1r27	ENSFHEP00000010181	ENSFHEP00000022511	Protein kinase domain-containing protein.	Protein phosphatase 1, regulatory subunit 27b.	0.487
ENSFHEP00000010423	ENSFHEP00000010181	ENSFHEP00000010423	ENSFHEP00000010181	Formin homology 2 domain containing 1.	Protein kinase domain-containing protein.	0.448
ENSFHEP00000010423	ENSFHEP00000019655	ENSFHEP00000010423	ENSFHEP00000019655	Formin homology 2 domain containing 1.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.901
ENSFHEP00000010423	ENSFHEP00000019697	ENSFHEP00000010423	ENSFHEP00000019697	Formin homology 2 domain containing 1.	Rho_Binding domain-containing protein.	0.901