(24 nodes) Sec7, C-terminal domain superfamily, and Negative regulation of protein localization to cell surface network (Fundulus heteroclitus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105938612	FERM domain containing 4A. (974 aa)
	IQSEC1	IQ motif and Sec7 domain 1. (1239 aa)
	ENSFHEP00000003138	SEC7 domain-containing protein. (346 aa)
	arl15	ADP-ribosylation factor-like 15a. (257 aa)
	LOC105935634	Cytohesin-1. (394 aa)
	ENSFHEP00000007495	Pleckstrin and Sec7 domain containing a. (218 aa)
	LOC105915444	Cytohesin 4b. (397 aa)
	LOC105936180	Cytohesin 1a. (414 aa)
	arl4a	ADP-ribosylation factor-like 4aa. (200 aa)
	LOC105928215	Cytohesin 1b. (420 aa)
	LOC105940050	IQ motif and Sec7 domain 1b. (921 aa)
	SMIM10	Small integral membrane protein 10. (60 aa)
	ENSFHEP00000012992	PH domain-containing protein. (179 aa)
	ENSFHEP00000014758	Uncharacterized protein. (112 aa)
	LOC105930824	Uncharacterized protein. (1122 aa)
	cytip	Cytohesin 1 interacting protein. (453 aa)
	iqsec2	IQ motif and Sec7 domain 2b. (1513 aa)
	cyth2	Cytohesin-2. (417 aa)
	LOC105936291	Uncharacterized protein. (652 aa)
	grasp	GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein. (378 aa)
	trim23	Tripartite motif containing 23. (580 aa)
	LOC105918714	SEC7 domain-containing protein. (1210 aa)
	LOC105938896	Cytohesin 4a. (397 aa)
	LOC105929083	ADP-ribosylation factor 6b; Belongs to the small GTPase superfamily. Arf family. (184 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000003138	ENSFHEP00000007495	ENSFHEP00000003138	ENSFHEP00000007495	SEC7 domain-containing protein.	Pleckstrin and Sec7 domain containing a.	0.452
ENSFHEP00000003138	ENSFHEP00000012992	ENSFHEP00000003138	ENSFHEP00000012992	SEC7 domain-containing protein.	PH domain-containing protein.	0.459
ENSFHEP00000003138	ENSFHEP00000014758	ENSFHEP00000003138	ENSFHEP00000014758	SEC7 domain-containing protein.	Uncharacterized protein.	0.451
ENSFHEP00000003138	LOC105915444	ENSFHEP00000003138	ENSFHEP00000007627	SEC7 domain-containing protein.	Cytohesin 4b.	0.459
ENSFHEP00000003138	LOC105928215	ENSFHEP00000003138	ENSFHEP00000009334	SEC7 domain-containing protein.	Cytohesin 1b.	0.459
ENSFHEP00000003138	LOC105929083	ENSFHEP00000003138	ENSFHEP00000032416	SEC7 domain-containing protein.	ADP-ribosylation factor 6b; Belongs to the small GTPase superfamily. Arf family.	0.451
ENSFHEP00000003138	LOC105930824	ENSFHEP00000003138	ENSFHEP00000016406	SEC7 domain-containing protein.	Uncharacterized protein.	0.452
ENSFHEP00000003138	LOC105935634	ENSFHEP00000003138	ENSFHEP00000005544	SEC7 domain-containing protein.	Cytohesin-1.	0.459
ENSFHEP00000003138	LOC105936180	ENSFHEP00000003138	ENSFHEP00000007832	SEC7 domain-containing protein.	Cytohesin 1a.	0.459
ENSFHEP00000003138	LOC105936291	ENSFHEP00000003138	ENSFHEP00000023580	SEC7 domain-containing protein.	Uncharacterized protein.	0.452
ENSFHEP00000003138	LOC105938896	ENSFHEP00000003138	ENSFHEP00000030004	SEC7 domain-containing protein.	Cytohesin 4a.	0.459
ENSFHEP00000003138	SMIM10	ENSFHEP00000003138	ENSFHEP00000012967	SEC7 domain-containing protein.	Small integral membrane protein 10.	0.434
ENSFHEP00000003138	cyth2	ENSFHEP00000003138	ENSFHEP00000020841	SEC7 domain-containing protein.	Cytohesin-2.	0.459
ENSFHEP00000007495	ENSFHEP00000003138	ENSFHEP00000007495	ENSFHEP00000003138	Pleckstrin and Sec7 domain containing a.	SEC7 domain-containing protein.	0.452
ENSFHEP00000007495	ENSFHEP00000012992	ENSFHEP00000007495	ENSFHEP00000012992	Pleckstrin and Sec7 domain containing a.	PH domain-containing protein.	0.490
ENSFHEP00000007495	ENSFHEP00000014758	ENSFHEP00000007495	ENSFHEP00000014758	Pleckstrin and Sec7 domain containing a.	Uncharacterized protein.	0.433
ENSFHEP00000007495	IQSEC1	ENSFHEP00000007495	ENSFHEP00000002162	Pleckstrin and Sec7 domain containing a.	IQ motif and Sec7 domain 1.	0.470
ENSFHEP00000007495	LOC105915444	ENSFHEP00000007495	ENSFHEP00000007627	Pleckstrin and Sec7 domain containing a.	Cytohesin 4b.	0.494
ENSFHEP00000007495	LOC105918714	ENSFHEP00000007495	ENSFHEP00000029002	Pleckstrin and Sec7 domain containing a.	SEC7 domain-containing protein.	0.470
ENSFHEP00000007495	LOC105928215	ENSFHEP00000007495	ENSFHEP00000009334	Pleckstrin and Sec7 domain containing a.	Cytohesin 1b.	0.490