(22 nodes) Mixed, incl. Clathrin coat of coated pit, and Clathrin-dependent synaptic vesicle endocytosis network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105934095	NECAP endocytosis associated 1. (263 aa)
	LOC105934093	Zgc:194578. (788 aa)
	ENSFHEP00000001960	EH domain-containing protein. (93 aa)
	LOC105939779	Flocculation protein FLO11. (1468 aa)
	eps15	Epidermal growth factor receptor pathway substrate 15. (1107 aa)
	picalm	Phosphatidylinositol binding clathrin assembly protein b. (681 aa)
	LOC105920702	Intersectin 2b. (1844 aa)
	ENSFHEP00000007368	Uncharacterized protein. (560 aa)
	ENSFHEP00000008800	Uncharacterized protein. (453 aa)
	itsn1	Intersectin 1 (SH3 domain protein). (1580 aa)
	LOC105919984	Epsin 3b. (575 aa)
	LOC105932062	Epsin 3a. (598 aa)
	ENSFHEP00000014736	Uncharacterized protein. (50 aa)
	ENSFHEP00000014864	Adaptor related protein complex 2 subunit sigma 1. (91 aa)
	LOC105939792	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (933 aa)
	LOC105939349	AP complex subunit beta. (923 aa)
	ENSFHEP00000021290	Uncharacterized protein. (362 aa)
	ENSFHEP00000025972	Uncharacterized protein. (512 aa)
	ENSFHEP00000026879	EH domain-containing protein. (108 aa)
	ENSFHEP00000030882	Adaptor related protein complex 2 subunit sigma 1. (53 aa)
	ap2m1	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (442 aa)
	LOC105925682	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (960 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000001960	ENSFHEP00000007368	ENSFHEP00000001960	ENSFHEP00000007368	EH domain-containing protein.	Uncharacterized protein.	0.999
ENSFHEP00000001960	ENSFHEP00000014736	ENSFHEP00000001960	ENSFHEP00000014736	EH domain-containing protein.	Uncharacterized protein.	0.740
ENSFHEP00000001960	ENSFHEP00000014864	ENSFHEP00000001960	ENSFHEP00000014864	EH domain-containing protein.	Adaptor related protein complex 2 subunit sigma 1.	0.794
ENSFHEP00000001960	ENSFHEP00000025972	ENSFHEP00000001960	ENSFHEP00000025972	EH domain-containing protein.	Uncharacterized protein.	0.999
ENSFHEP00000001960	ENSFHEP00000030882	ENSFHEP00000001960	ENSFHEP00000030882	EH domain-containing protein.	Adaptor related protein complex 2 subunit sigma 1.	0.794
ENSFHEP00000001960	LOC105919984	ENSFHEP00000001960	ENSFHEP00000011042	EH domain-containing protein.	Epsin 3b.	0.893
ENSFHEP00000001960	LOC105920702	ENSFHEP00000001960	ENSFHEP00000007082	EH domain-containing protein.	Intersectin 2b.	0.999
ENSFHEP00000001960	LOC105925682	ENSFHEP00000001960	ENSFHEP00000032379	EH domain-containing protein.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.780
ENSFHEP00000001960	LOC105932062	ENSFHEP00000001960	ENSFHEP00000012859	EH domain-containing protein.	Epsin 3a.	0.952
ENSFHEP00000001960	LOC105934093	ENSFHEP00000001960	ENSFHEP00000000922	EH domain-containing protein.	Zgc:194578.	0.940
ENSFHEP00000001960	LOC105934095	ENSFHEP00000001960	ENSFHEP00000000920	EH domain-containing protein.	NECAP endocytosis associated 1.	0.694
ENSFHEP00000001960	LOC105939349	ENSFHEP00000001960	ENSFHEP00000019378	EH domain-containing protein.	AP complex subunit beta.	0.740
ENSFHEP00000001960	LOC105939779	ENSFHEP00000001960	ENSFHEP00000002034	EH domain-containing protein.	Flocculation protein FLO11.	0.937
ENSFHEP00000001960	LOC105939792	ENSFHEP00000001960	ENSFHEP00000017363	EH domain-containing protein.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.894
ENSFHEP00000001960	ap2m1	ENSFHEP00000001960	ENSFHEP00000032273	EH domain-containing protein.	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.840
ENSFHEP00000001960	itsn1	ENSFHEP00000001960	ENSFHEP00000010978	EH domain-containing protein.	Intersectin 1 (SH3 domain protein).	0.937
ENSFHEP00000001960	picalm	ENSFHEP00000001960	ENSFHEP00000004388	EH domain-containing protein.	Phosphatidylinositol binding clathrin assembly protein b.	0.719
ENSFHEP00000007368	ENSFHEP00000001960	ENSFHEP00000007368	ENSFHEP00000001960	Uncharacterized protein.	EH domain-containing protein.	0.999
ENSFHEP00000007368	ENSFHEP00000008800	ENSFHEP00000007368	ENSFHEP00000008800	Uncharacterized protein.	Uncharacterized protein.	0.999
ENSFHEP00000007368	ENSFHEP00000014736	ENSFHEP00000007368	ENSFHEP00000014736	Uncharacterized protein.	Uncharacterized protein.	0.998