(44 nodes) Mixed, incl. Purine nucleotide salvage, and Uridine-diphosphatase activity network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ak4	GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (226 aa)
	LOC105937320	Phosphodiesterase. (659 aa)
	PDE2A	Phosphodiesterase. (955 aa)
	LOC105924214	Adenylate kinase 7a. (644 aa)
	LOC105939193	Phosphodiesterase. (727 aa)
	LOC105933887	Phosphodiesterase. (767 aa)
	ak2	Adenylate kinase 2; Belongs to the adenylate kinase family. (240 aa)
	PDE7B	Phosphodiesterase. (439 aa)
	ak6	Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (172 aa)
	pde1a	Phosphodiesterase. (484 aa)
	NT5C3B	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (293 aa)
	aprt	Adenine phosphoribosyltransferase. (181 aa)
	PDE1C	Phosphodiesterase. (536 aa)
	LOC105915950	Uridine-cytidine kinase; Belongs to the uridine kinase family. (261 aa)
	ak7	Adenylate kinase 7b. (650 aa)
	LOC105927006	Deoxyguanosine kinase. (309 aa)
	pde4d	Phosphodiesterase. (836 aa)
	entpd4	Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (618 aa)
	LOC105929062	Ectonucleoside triphosphate diphosphohydrolase 5b; Belongs to the GDA1/CD39 NTPase family. (458 aa)
	dck	Deoxycytidine kinase. (263 aa)
	entpd1	Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (498 aa)
	LOC105919179	Adenylate cyclase type 4. (1297 aa)
	LOC105930751	Ectonucleotide pyrophosphatase/phosphodiesterase 1. (734 aa)
	LOC105918498	dNK domain-containing protein. (266 aa)
	pde7a	Phosphodiesterase. (506 aa)
	ak1	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (202 aa)
	entpd3	Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (500 aa)
	LOC105927134	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (666 aa)
	ampd3	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (793 aa)
	LOC105936968	Adenosine kinase a. (387 aa)
	entpd6	Ectonucleoside triphosphate diphosphohydrolase 6; Belongs to the GDA1/CD39 NTPase family. (260 aa)
	cant1	Calcium activated nucleotidase 1a. (425 aa)
	ENSFHEP00000026104	Zgc:112492. (597 aa)
	ak8	Adenylate kinase 8; Belongs to the adenylate kinase family. (442 aa)
	ampd1	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (737 aa)
	ADK	Adenosine kinase. (357 aa)
	LOC105934356	5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (528 aa)
	NT5C3B-2	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (305 aa)
	LOC105916450	SMB domain-containing protein. (822 aa)
	pde1b	Phosphodiesterase. (519 aa)
	LOC105917436	Ectonucleoside triphosphate diphosphohydrolase 5a; Belongs to the GDA1/CD39 NTPase family. (498 aa)
	ak5	Adenylate kinase 5; Belongs to the adenylate kinase family. (565 aa)
	LOC105915750	Calcium activated nucleotidase 1b. (444 aa)
	LOC105926233	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (773 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADK	LOC105915950	ENSFHEP00000027560	ENSFHEP00000012328	Adenosine kinase.	Uridine-cytidine kinase; Belongs to the uridine kinase family.	0.443
ADK	LOC105916450	ENSFHEP00000027560	ENSFHEP00000028586	Adenosine kinase.	SMB domain-containing protein.	0.950
ADK	LOC105918498	ENSFHEP00000027560	ENSFHEP00000022940	Adenosine kinase.	dNK domain-containing protein.	0.725
ADK	LOC105924214	ENSFHEP00000027560	ENSFHEP00000002692	Adenosine kinase.	Adenylate kinase 7a.	0.970
ADK	LOC105926233	ENSFHEP00000027560	ENSFHEP00000033387	Adenosine kinase.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.967
ADK	LOC105927006	ENSFHEP00000027560	ENSFHEP00000014975	Adenosine kinase.	Deoxyguanosine kinase.	0.538
ADK	LOC105927134	ENSFHEP00000027560	ENSFHEP00000024187	Adenosine kinase.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.967
ADK	LOC105930751	ENSFHEP00000027560	ENSFHEP00000020862	Adenosine kinase.	Ectonucleotide pyrophosphatase/phosphodiesterase 1.	0.950
ADK	LOC105933887	ENSFHEP00000027560	ENSFHEP00000005269	Adenosine kinase.	Phosphodiesterase.	0.941
ADK	LOC105934356	ENSFHEP00000027560	ENSFHEP00000028277	Adenosine kinase.	5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family.	0.974
ADK	LOC105936968	ENSFHEP00000027560	ENSFHEP00000025614	Adenosine kinase.	Adenosine kinase a.	0.947
ADK	LOC105937320	ENSFHEP00000027560	ENSFHEP00000000905	Adenosine kinase.	Phosphodiesterase.	0.960
ADK	LOC105939193	ENSFHEP00000027560	ENSFHEP00000004153	Adenosine kinase.	Phosphodiesterase.	0.960
ADK	NT5C3B	ENSFHEP00000027560	ENSFHEP00000008749	Adenosine kinase.	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family.	0.896
ADK	NT5C3B-2	ENSFHEP00000027560	ENSFHEP00000028342	Adenosine kinase.	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family.	0.944
ADK	PDE1C	ENSFHEP00000027560	ENSFHEP00000010728	Adenosine kinase.	Phosphodiesterase.	0.943
ADK	PDE2A	ENSFHEP00000027560	ENSFHEP00000002103	Adenosine kinase.	Phosphodiesterase.	0.942
ADK	PDE7B	ENSFHEP00000027560	ENSFHEP00000006860	Adenosine kinase.	Phosphodiesterase.	0.961
ADK	ak1	ENSFHEP00000027560	ENSFHEP00000022992	Adenosine kinase.	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	0.962
ADK	ak2	ENSFHEP00000027560	ENSFHEP00000006651	Adenosine kinase.	Adenylate kinase 2; Belongs to the adenylate kinase family.	0.986