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LOC105923381 LOC105923381 LOC105923388 LOC105923388 LOC105926682 LOC105926682 nfs1 nfs1 LOC105924328 LOC105924328 LOC105939773 LOC105939773 LOC105936944 LOC105936944 ciao1 ciao1 LOC105918959 LOC105918959 nubp1 nubp1 LOC105917248 LOC105917248 isca1 isca1 hmbs hmbs LOC105917191 LOC105917191 lto1 lto1 cpox cpox scly scly lias lias ENSFHEP00000007674 ENSFHEP00000007674 itih5 itih5 hmox1 hmox1 LOC105924844 LOC105924844 yae1 yae1 uros uros abcb7 abcb7 LOC105915304 LOC105915304 ENSFHEP00000011998 ENSFHEP00000011998 slc19a2 slc19a2 ppox ppox bbx bbx iscu iscu ENSFHEP00000014170 ENSFHEP00000014170 LOC105923061 LOC105923061 alad alad mms19 mms19 nubpl nubpl narf narf LOC105919788 LOC105919788 LOC105926861 LOC105926861 fth1 fth1 LOC105926839 LOC105926839 rnls rnls blvrb blvrb abcb6 abcb6 ciapin1 ciapin1 ENSFHEP00000019469 ENSFHEP00000019469 lipt2 lipt2 ENSFHEP00000019790 ENSFHEP00000019790 ciao3 ciao3 nubp2 nubp2 LOC105938766 LOC105938766 LOC105938729 LOC105938729 SLC25A28 SLC25A28 slc25a19 slc25a19 ENDOV ENDOV tpk1 tpk1 ndor1 ndor1 LOC105932944 LOC105932944 LOC105932257 LOC105932257 itih3 itih3 LOC105926009 LOC105926009 snx25 snx25 ENSFHEP00000024582 ENSFHEP00000024582 LOC105915495 LOC105915495 LOC105915496 LOC105915496 thtpa thtpa CIAO2A CIAO2A ENSFHEP00000026303 ENSFHEP00000026303 LOC105923715 LOC105923715 slc25a38 slc25a38 LOC105936705 LOC105936705 pcnp pcnp slc40a1 slc40a1 abcb10 abcb10 lyrm4 lyrm4 ciao2b ciao2b lipt1 lipt1 LOC105929230 LOC105929230 LOC105929218 LOC105929218 bola1 bola1 ENSFHEP00000029546 ENSFHEP00000029546 LOC105915220 LOC105915220 isca2 isca2 MOCOS MOCOS urod urod LOC105916219 LOC105916219 glrx5 glrx5
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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LOC105923381Solute carrier family 19 member 3a. (485 aa)
LOC105923388Solute carrier family 19 member 3b. (463 aa)
LOC105926682Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (174 aa)
nfs1NFS1 cysteine desulfurase. (449 aa)
LOC105924328Cytochrome b reductase 1. (276 aa)
LOC105939773Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis. Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. (286 aa)
LOC105936944Ceruloplasmin; Belongs to the multicopper oxidase family. (1072 aa)
ciao1Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Belongs to the WD repeat CIA1 family. (330 aa)
LOC105918959Magnesium transporter. (353 aa)
nubp1Cytosolic Fe-S cluster assembly factor NUBP1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (361 aa)
LOC105917248Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (177 aa)
isca1Iron-sulfur cluster assembly 1. (136 aa)
hmbsHydroxymethylbilane synthase a. (359 aa)
LOC105917191Solute carrier family 25 member 39; Belongs to the mitochondrial carrier (TC 2.A.29) family. (358 aa)
lto1LTO1 maturation factor of ABCE1. (171 aa)
cpoxCoproporphyrinogen oxidase. (452 aa)
sclySelenocysteine lyase. (407 aa)
liasLipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (393 aa)
ENSFHEP00000007674ITI_HC_C domain-containing protein. (249 aa)
itih5Inter-alpha-trypsin inhibitor heavy chain 5. (968 aa)
hmox1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (270 aa)
LOC105924844Heme oxygenase 2b. (309 aa)
yae1OTU deubiquitinase with linear linkage specificity a. (204 aa)
urosUroporphyrinogen III synthase. (261 aa)
abcb7ATP-binding cassette, sub-family B (MDR/TAP), member 7. (746 aa)
LOC105915304Iron-sulfur cluster assembly enzyme ISCU, mitochondrial; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (165 aa)
ENSFHEP00000011998Inter-alpha-trypsin inhibitor heavy chain family member 6. (1204 aa)
slc19a2Solute carrier family 19 member 2. (484 aa)
ppoxProtoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (433 aa)
bbxBBX high mobility group box domain containing. (802 aa)
iscuIron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (219 aa)
ENSFHEP00000014170FeS_assembly_P domain-containing protein. (108 aa)
LOC105923061Biliverdin reductase A. (250 aa)
aladDelta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (305 aa)
mms19MMS19 homolog, cytosolic iron-sulfur assembly component. (1002 aa)
nubplNucleotide binding protein-like. (334 aa)
narfNuclear prelamin A recognition factor; Belongs to the NARF family. (465 aa)
LOC105919788Hephaestin-like 1b; Belongs to the multicopper oxidase family. (1015 aa)
LOC105926861Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family. (338 aa)
fth1Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (180 aa)
LOC105926839NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae). (256 aa)
rnlsRenalase, FAD-dependent amine oxidase. (347 aa)
blvrbBiliverdin reductase B. (230 aa)
abcb6ATP-binding cassette, sub-family B (MDR/TAP), member 6a. (854 aa)
ciapin1Anamorsin; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electron [...] (334 aa)
ENSFHEP00000019469Uncharacterized protein. (128 aa)
lipt2Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. Belongs to the LipB family. (254 aa)
ENSFHEP00000019790Glutaredoxin 3. (324 aa)
ciao3Nuclear prelamin A recognition factor-like; Belongs to the NARF family. (476 aa)
nubp2Cytosolic Fe-S cluster assembly factor NUBP2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (268 aa)
LOC105938766Zgc:110319. (256 aa)
LOC105938729Solute carrier family 25 member 28; Belongs to the mitochondrial carrier (TC 2.A.29) family. (393 aa)
SLC25A28Solute carrier family 25 member 28; Belongs to the mitochondrial carrier (TC 2.A.29) family. (401 aa)
slc25a19Solute carrier family 25 member 19; Belongs to the mitochondrial carrier (TC 2.A.29) family. (328 aa)
ENDOVEndonuclease V. (249 aa)
tpk1Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. (252 aa)
ndor1NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (594 aa)
LOC105932944Cytochrome c oxidase assembly protein COX16, mitochondrial. (106 aa)
LOC105932257Transmembrane protein 14Cb. (106 aa)
itih3Uncharacterized protein. (857 aa)
LOC105926009Uncharacterized protein. (839 aa)
snx25Sorting nexin-25. (981 aa)
ENSFHEP00000024582Uncharacterized protein. (89 aa)
LOC105915495Uncharacterized protein. (591 aa)
LOC105915496Uncharacterized protein. (556 aa)
thtpaThiamine triphosphatase. (223 aa)
CIAO2ACytosolic iron-sulfur assembly component 2A. (109 aa)
ENSFHEP00000026303VIT domain-containing protein. (309 aa)
LOC105923715Uncharacterized protein. (164 aa)
slc25a38Solute carrier family 25 member 38a; Belongs to the mitochondrial carrier (TC 2.A.29) family. (347 aa)
LOC105936705Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (277 aa)
pcnpPEST proteolytic signal containing nuclear protein. (169 aa)
slc40a1Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (565 aa)
abcb10ATP-binding cassette, sub-family B (MDR/TAP), member 10. (714 aa)
lyrm4Si:ch211-152c8.4; Belongs to the complex I LYR family. (85 aa)
ciao2bCytosolic iron-sulfur assembly component 2B. (159 aa)
lipt1Lipoyltransferase 1. (380 aa)
LOC105929230Heme oxygenase 2a. (320 aa)
LOC105929218Heme oxygenase 2a. (286 aa)
bola1BolA family member 1; Belongs to the BolA/IbaG family. (150 aa)
ENSFHEP00000029546Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (371 aa)
LOC105915220Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. (384 aa)
isca2Iron-sulfur cluster assembly 2, mitochondrial. (178 aa)
MOCOSMolybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. (834 aa)
urodUroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family. (368 aa)
LOC105916219BolA family member 2; Belongs to the BolA/IbaG family. (86 aa)
glrx5Glutaredoxin 5 homolog (S. cerevisiae). (156 aa)
Your Current Organism:
Fundulus heteroclitus
NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog
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