(134 nodes) Mixed, incl. Homeobox, conserved site, and p53-like transcription factor, DNA-binding domain superfamily network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	gata4	GATA binding protein 4. (395 aa)
	lhx8	LIM homeobox 8b. (277 aa)
	LOC105927878	Single stranded DNA binding protein 3b. (383 aa)
	LOC105932327	ISL LIM homeobox 2a. (359 aa)
	LOC105919611	GATA binding protein 1a. (424 aa)
	bhlhe23	Basic helix-loop-helix family, member e23. (227 aa)
	LOC105926657	Paired box 10. (256 aa)
	lhx9	LIM homeobox 9. (399 aa)
	hinfp	Histone H4 transcription factor. (484 aa)
	LOC105938673	LIM domain binding 1a. (393 aa)
	TCF24	Transcription factor 24. (176 aa)
	prrx1	Paired related homeobox 1a. (248 aa)
	LOC105918457	LIM domain only 4a. (169 aa)
	ENSFHEP00000003392	Heart and neural crest derivatives expressed 2. (235 aa)
	arx	Aristaless related homeobox a. (447 aa)
	LOC105930100	Cone-rod homeobox. (295 aa)
	drgx	Dorsal root ganglia homeobox. (292 aa)
	lmo4	LIM domain only 4b. (232 aa)
	phf24	PHD finger protein 24. (408 aa)
	LOC105939731	Zgc:112083. (509 aa)
	LOC105930613	T-box transcription factor 18. (514 aa)
	OTP	Orthopedia homeobox. (312 aa)
	LOC110368566	Intestine-specific homeobox. (215 aa)
	tbx21	T-box transcription factor 21. (614 aa)
	lhx5	LIM homeobox 5. (396 aa)
	ENSFHEP00000005422	Folliculogenesis specific bHLH transcription factor. (212 aa)
	shox2	Short stature homeobox 2. (301 aa)
	tbx1	T-box transcription factor TBX1. (498 aa)
	ENSFHEP00000005963	BHLH domain-containing protein. (215 aa)
	LOC105925956	Runt-related transcription factor. (421 aa)
	LOC105915463	Runt-related transcription factor. (483 aa)
	RGS9BP	Regulator of G protein signaling 9 binding protein. (230 aa)
	LOC105939052	Single-stranded DNA-binding protein 3. (382 aa)
	gata3	Trans-acting T-cell-specific transcription factor GATA-3. (441 aa)
	ENSFHEP00000008666	BHLH domain-containing protein. (105 aa)
	zfpm2	Zinc finger protein, FOG family member 2a. (1140 aa)
	hmx3	H6 family homeobox 3. (261 aa)
	zfpm1	Zinc finger protein, FOG family member 1. (1199 aa)
	LOC105937097	Transcription factor 23. (242 aa)
	LOC105926883	Uncharacterized protein. (529 aa)
	LOC105915362	Si:dkey-90l8.3. (173 aa)
	rbm18	RNA binding motif protein 18. (200 aa)
	GSC2	Goosecoid homeobox 2. (98 aa)
	runx1t1	RUNX1 partner transcriptional co-repressor 1. (592 aa)
	LOC105936611	GATA binding protein 5. (372 aa)
	uncx	UNC homeobox. (464 aa)
	LOC105915904	Si:dkey-43p13.5. (233 aa)
	barhl1	Homeobox domain-containing protein. (226 aa)
	TBX22	T-box transcription factor 22. (489 aa)
	tbx15	T-box transcription factor TBX15. (610 aa)
	LOC105932073	LIM homeobox transcription factor 1, alpha-like. (407 aa)
	pou1f1	POU domain protein. (360 aa)
	LOC105915854	Uncharacterized protein. (336 aa)
	en2	Homeobox protein engrailed-like. (269 aa)
	LOC105933177	Uncharacterized protein. (254 aa)
	fli1	Fli-1 proto-oncogene, ETS transcription factor a. (467 aa)
	LOC105929648	Homeobox domain-containing protein. (306 aa)
	ENSFHEP00000016585	BHLH domain-containing protein. (82 aa)
	LOC105930785	T-box transcription factor 5a. (524 aa)
	en1	Homeobox protein engrailed-like. (284 aa)
	gsx2	GS homeobox 2. (239 aa)
	spi1	Transcription factor PU.1. (264 aa)
	LOC105939442	Unc4.1 homeobox (C. elegans). (514 aa)
	LOC105916285	Homeobox aristaless 4-like protein. (373 aa)
	alx1	ALX homeobox 1. (315 aa)
	LOC105931907	T cell leukemia homeobox 2. (365 aa)
	runx2	Runt-related transcription factor. (464 aa)
	ENSFHEP00000019009	LIM domain only 3. (69 aa)
	ENSFHEP00000019242	NK1 transcription factor related 2-like,a. (188 aa)
	dmrt2	Doublesex and mab-3 related transcription factor 2a. (593 aa)
	dmrt3	Doublesex and mab-3 related transcription factor 3a. (532 aa)
	ENSFHEP00000019525	Homeobox domain-containing protein. (249 aa)
	LOC105931869	Ig-like domain-containing protein. (731 aa)
	TBX2	T-box transcription factor 2. (686 aa)
	LOC105940321	Uncharacterized protein. (349 aa)
	nkx2-1	Homeobox protein Nkx-2.1. (354 aa)
	LOC105917284	Homeobox domain-containing protein. (273 aa)
	LOC105934619	Homeobox domain-containing protein. (248 aa)
	SSBP4	Single stranded DNA binding protein 4. (385 aa)
	LOC105915581	Homeobox protein engrailed-like. (263 aa)
	ENSFHEP00000022320	BHLH domain-containing protein. (129 aa)
	LOC105937255	Si:ch211-236k19.2. (346 aa)
	LOC105937256	T-cell acute lymphocytic leukemia 2. (112 aa)
	LOC105926842	Iroquois homeobox 7. (325 aa)
	LHX3	LIM homeobox 3. (400 aa)
	lrrc57	Leucine rich repeat containing 57. (234 aa)
	LOC105928411	Uncharacterized protein. (744 aa)
	bhlha9	Basic helix-loop-helix family, member a9. (284 aa)
	lhx4	LIM homeobox 4. (389 aa)
	LOC105935283	CCAAT enhancer binding protein beta. (288 aa)
	rchy1	Uncharacterized protein. (270 aa)
	LOC105920803	LIM and cysteine-rich domains 1. (355 aa)
	tcf21	Transcription factor 21. (175 aa)
	ssbp2	Single-stranded DNA-binding protein 2. (360 aa)
	myb	V-myb avian myeloblastosis viral oncogene homolog. (588 aa)
	mab21l2	Mab-21 3-like protein. (359 aa)
	LOC105933450	LIM domain only 1. (155 aa)
	gata6	Transcription factor GATA-4. (491 aa)
	ASCL4	Achaete-scute family bHLH transcription factor 4. (189 aa)
	LOC105938502	Homeobox aristaless 4-like protein. (400 aa)
	lmo2	LIM domain only 2 (rhombotin-like 1). (156 aa)
	LOC105938486	Cyclic nucleotide-binding domain-containing protein. (1168 aa)
	ENSFHEP00000026861	Achaete-scute family bHLH transcription factor 1b. (179 aa)
	LOC105917710	TLE family member 5, transcriptional modulator. (203 aa)
	DMRTA1	Doublesex-and mab-3-related transcription factor A1. (421 aa)
	barhl2	BarH-like homeobox 2. (366 aa)
	cebpa	CCAAT/enhancer-binding protein. (296 aa)
	TCF4	Transcription factor 4. (607 aa)
	ISL2	ISL LIM homeobox 2b. (360 aa)
	LOC105919375	ISL LIM homeobox 1. (298 aa)
	LOC105920540	Uncharacterized protein. (271 aa)
	LOC105933293	Runt domain-containing protein. (308 aa)
	LOC105920490	Homeobox domain-containing protein. (170 aa)
	ENSFHEP00000029453	Uncharacterized protein. (255 aa)
	LOC105931464	H6 family homeobox 4. (224 aa)
	ENSFHEP00000030437	Paired domain-containing protein. (153 aa)
	scx	Scleraxis bHLH transcription factor a. (215 aa)
	ENSFHEP00000031731	BHLH domain-containing protein. (97 aa)
	cbfb	Core-binding factor subunit beta. (174 aa)
	LOC105926231	Synaptic vesicle glycoprotein 2. (427 aa)
	LOC105935913	T-cell acute lymphocytic leukemia protein 1. (478 aa)
	ldb1	LIM-domain binding 1b. (359 aa)
	ENSFHEP00000032666	Uncharacterized protein. (64 aa)
	LOC105931932	LIM domain binding 2a. (390 aa)
	LOC105926203	Rhombotin-1. (155 aa)
	LOC105926164	Homeobox domain-containing protein. (224 aa)
	OTP-2	Orthopedia homeobox b. (328 aa)
	dbx1	Developing brain homeobox 1a. (311 aa)
	nr4a2	Nuclear receptor subfamily 4, group A, member 2b. (601 aa)
	helt	Helt bHLH transcription factor. (196 aa)
	LOC105939303	Zgc:101100. (275 aa)
	ENSFHEP00000034749	T-box brain transcription factor 1b. (406 aa)
	ENSFHEP00000034800	Uncharacterized protein. (172 aa)
	LOC105927810	Diencephalon/mesencephalon homeobox 1b. (400 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCL4	LOC105931932	ENSFHEP00000026159	ENSFHEP00000032695	Achaete-scute family bHLH transcription factor 4.	LIM domain binding 2a.	0.509
ASCL4	LOC105938673	ENSFHEP00000026159	ENSFHEP00000003000	Achaete-scute family bHLH transcription factor 4.	LIM domain binding 1a.	0.509
ASCL4	TCF4	ENSFHEP00000026159	ENSFHEP00000028153	Achaete-scute family bHLH transcription factor 4.	Transcription factor 4.	0.644
ASCL4	bhlha9	ENSFHEP00000026159	ENSFHEP00000023742	Achaete-scute family bHLH transcription factor 4.	Basic helix-loop-helix family, member a9.	0.588
ASCL4	bhlhe23	ENSFHEP00000026159	ENSFHEP00000001802	Achaete-scute family bHLH transcription factor 4.	Basic helix-loop-helix family, member e23.	0.602
ASCL4	cbfb	ENSFHEP00000026159	ENSFHEP00000031734	Achaete-scute family bHLH transcription factor 4.	Core-binding factor subunit beta.	0.480
ASCL4	ldb1	ENSFHEP00000026159	ENSFHEP00000032580	Achaete-scute family bHLH transcription factor 4.	LIM-domain binding 1b.	0.509
ASCL4	phf24	ENSFHEP00000026159	ENSFHEP00000004115	Achaete-scute family bHLH transcription factor 4.	PHD finger protein 24.	0.422
DMRTA1	ENSFHEP00000034800	ENSFHEP00000026985	ENSFHEP00000034800	Doublesex-and mab-3-related transcription factor A1.	Uncharacterized protein.	0.605
DMRTA1	gsx2	ENSFHEP00000026985	ENSFHEP00000017460	Doublesex-and mab-3-related transcription factor A1.	GS homeobox 2.	0.638
ENSFHEP00000003392	ISL2	ENSFHEP00000003392	ENSFHEP00000028248	Heart and neural crest derivatives expressed 2.	ISL LIM homeobox 2b.	0.460
ENSFHEP00000003392	LOC105915463	ENSFHEP00000003392	ENSFHEP00000007030	Heart and neural crest derivatives expressed 2.	Runt-related transcription factor.	0.433
ENSFHEP00000003392	LOC105916285	ENSFHEP00000003392	ENSFHEP00000018279	Heart and neural crest derivatives expressed 2.	Homeobox aristaless 4-like protein.	0.610
ENSFHEP00000003392	LOC105919375	ENSFHEP00000003392	ENSFHEP00000028344	Heart and neural crest derivatives expressed 2.	ISL LIM homeobox 1.	0.445
ENSFHEP00000003392	LOC105919611	ENSFHEP00000003392	ENSFHEP00000001731	Heart and neural crest derivatives expressed 2.	GATA binding protein 1a.	0.500
ENSFHEP00000003392	LOC105920540	ENSFHEP00000003392	ENSFHEP00000028444	Heart and neural crest derivatives expressed 2.	Uncharacterized protein.	0.500
ENSFHEP00000003392	LOC105925956	ENSFHEP00000003392	ENSFHEP00000006252	Heart and neural crest derivatives expressed 2.	Runt-related transcription factor.	0.433
ENSFHEP00000003392	LOC105926883	ENSFHEP00000003392	ENSFHEP00000010411	Heart and neural crest derivatives expressed 2.	Uncharacterized protein.	0.505
ENSFHEP00000003392	LOC105930785	ENSFHEP00000003392	ENSFHEP00000016655	Heart and neural crest derivatives expressed 2.	T-box transcription factor 5a.	0.669
ENSFHEP00000003392	LOC105931932	ENSFHEP00000003392	ENSFHEP00000032695	Heart and neural crest derivatives expressed 2.	LIM domain binding 2a.	0.509