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| | brip1 | BRCA1 interacting protein C-terminal helicase 1. (1443 aa) |
| | rfc3 | Replication factor C (activator 1) 3. (356 aa) |
| | usp1 | Ubiquitin carboxyl-terminal hydrolase. (798 aa) |
| | ENSFHEP00000001052 | Uncharacterized protein. (300 aa) |
| | ENSFHEP00000001065 | Piezo_RRas_bdg domain-containing protein. (357 aa) |
| | dscc1 | DNA replication and sister chromatid cohesion 1. (391 aa) |
| | ENSFHEP00000001801 | Bloom syndrome, RecQ helicase. (1405 aa) |
| | mus81 | MUS81 structure-specific endonuclease subunit. (612 aa) |
| | pola2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (605 aa) |
| | atrip | Uncharacterized protein. (774 aa) |
| | cdc6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (583 aa) |
| | ddx11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11. (898 aa) |
| | ankrd12 | Ankyrin repeat domain 12. (1806 aa) |
| | pole4 | Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa) |
| | PIEZO2 | Piezo-type mechanosensitive ion channel component. (2950 aa) |
| | pola1 | DNA polymerase. (1507 aa) |
| | USP12 | USP domain-containing protein; Belongs to the peptidase C19 family. (213 aa) |
| | LOC105921368 | RING-type domain-containing protein. (233 aa) |
| | palb2 | PALB2_WD40 domain-containing protein. (1269 aa) |
| | dclre1b | DNA cross-link repair 1B. (533 aa) |
| | rfc5 | Replication factor C (activator 1) 5. (335 aa) |
| | LOC105917231 | Cell division cycle associated 7a. (406 aa) |
| | exo1 | Exonuclease 1. (743 aa) |
| | LOC105920752 | Ubiquitin-conjugating enzyme E2T (putative). (194 aa) |
| | ENSFHEP00000005153 | Uncharacterized protein. (137 aa) |
| | rad18 | RAD18 E3 ubiquitin protein ligase. (435 aa) |
| | msh6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1301 aa) |
| | ENSFHEP00000005309 | Uncharacterized protein. (363 aa) |
| | ENSFHEP00000005371 | Uncharacterized protein. (597 aa) |
| | polk | Polymerase (DNA directed) kappa. (509 aa) |
| | orc5 | Origin recognition complex, subunit 5. (429 aa) |
| | rad51d | RAD51 paralog D. (334 aa) |
| | ercc6l | Excision repair cross-complementation group 6-like. (1185 aa) |
| | chek2 | Checkpoint kinase 2. (458 aa) |
| | timeless | Timeless circadian clock. (1259 aa) |
| | slf1 | Ankyrin repeat domain-containing protein 16. (887 aa) |
| | ENSFHEP00000007314 | Uncharacterized protein. (235 aa) |
| | mcph1 | Microcephalin 1. (809 aa) |
| | ercc1 | Excision repair cross-complementation group 1. (366 aa) |
| | rad51 | RAD51 recombinase; Belongs to the RecA family. (142 aa) |
| | ube2n | Ubiquitin-conjugating enzyme E2Nb; Belongs to the ubiquitin-conjugating enzyme family. (169 aa) |
| | LOC105923252 | ATPase family AAA domain containing 5a. (1743 aa) |
| | FANCA | FA complementation group A. (990 aa) |
| | gins1 | GINS complex subunit 1 (Psf1 homolog). (219 aa) |
| | ENSFHEP00000007971 | WD_REPEATS_REGION domain-containing protein. (314 aa) |
| | ENSFHEP00000008011 | HMG box domain-containing protein. (163 aa) |
| | fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (368 aa) |
| | tdrd3 | Tudor domain containing 3. (786 aa) |
| | LOC105922669 | RAD54 like. (592 aa) |
| | bivm | Basic, immunoglobulin-like variable motif containing. (497 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (235 aa) |
| | exd2 | Exonuclease 3'-5' domain containing 2. (639 aa) |
| | rad50 | RAD50 homolog, double strand break repair protein. (1312 aa) |
| | dna2 | Uncharacterized protein. (1356 aa) |
| | mdc1 | BRCT domain-containing protein. (1718 aa) |
| | fancg | FA complementation group G. (621 aa) |
| | brca2 | BRCA2 DNA repair associated. (2841 aa) |
| | LOC105929858 | Polymerase (DNA directed), epsilon 2. (482 aa) |
| | slx4 | SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1496 aa) |
| | xrcc3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (344 aa) |
| | hus1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | pole | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2016 aa) |
| | orc3 | Origin recognition complex, subunit 3. (612 aa) |
| | ten1 | TEN1 subunit of CST complex. (135 aa) |
| | mad2l2 | Mitotic arrest deficient 2 like 2. (210 aa) |
| | LOC105920513 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (760 aa) |
| | mcm8 | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (684 aa) |
| | RPA1 | Uncharacterized protein. (253 aa) |
| | msh5 | MutS homolog 5. (816 aa) |
| | rad54b | RAD54 homolog B. (881 aa) |
| | stn1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (357 aa) |
| | ENSFHEP00000013136 | WD-3 domain-containing protein. (283 aa) |
| | mcm7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (724 aa) |
| | pole3 | Uncharacterized protein. (96 aa) |
| | msh4 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (854 aa) |
| | tp53bp1 | Tumor protein p53 binding protein, 1. (1253 aa) |
| | dmc1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa) |
| | hltf | Helicase-like transcription factor. (842 aa) |
| | LOC105925236 | Flap endonuclease 1. (348 aa) |
| | ercc4 | Excision repair cross-complementation group 4. (897 aa) |
| | atr | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2414 aa) |
| | ENSFHEP00000015746 | Uncharacterized protein. (133 aa) |
| | ENSFHEP00000015766 | Uncharacterized protein. (156 aa) |
| | prim1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (425 aa) |
| | rad51c | RAD51 paralog C. (341 aa) |
| | fancc | FA complementation group C. (633 aa) |
| | LOC105933722 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (151 aa) |
| | ercc6l2 | Excision repair cross-complementation group 6-like 2. (1538 aa) |
| | dbf4 | DBF4 zinc finger. (408 aa) |
| | wdr48 | WD repeat domain 48b. (700 aa) |
| | ENSFHEP00000016680 | Uncharacterized protein. (268 aa) |
| | mcm10 | Minichromosome maintenance 10 replication initiation factor. (890 aa) |
| | cdc45 | CDC45 cell division cycle 45 homolog (S. cerevisiae). (367 aa) |
| | orc2 | Origin recognition complex, subunit 2. (573 aa) |
| | LOC105924820 | Uncharacterized protein. (341 aa) |
| | LOC105937671 | RPA_C domain-containing protein. (247 aa) |
| | mlh1 | MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (715 aa) |
| | CLSPN | Claspin. (893 aa) |
| | recql5 | RecQ helicase-like 5. (1014 aa) |
| | LOC105926799 | Uncharacterized protein. (443 aa) |
| | LOC105928579 | NTF2 domain-containing protein. (130 aa) |
| | LOC105934822 | Ubiquitin carboxyl-terminal hydrolase. (386 aa) |
| | CENPS | Centromere protein S. (115 aa) |
| | rbbp8 | Uncharacterized protein. (663 aa) |
| | fancb | FA complementation group B. (848 aa) |
| | gins2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (186 aa) |
| | gins3 | GINS complex subunit 3. (245 aa) |
| | msh3 | MutS homolog 3 (E. coli). (924 aa) |
| | rhno1 | Si:ch73-352p4.5. (291 aa) |
| | LOC105922837 | BRCT domain-containing protein. (146 aa) |
| | rmi1 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (687 aa) |
| | LOC105916216 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (262 aa) |
| | ENSFHEP00000020833 | Uncharacterized protein. (136 aa) |
| | prim2 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (505 aa) |
| | ENSFHEP00000021145 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (575 aa) |
| | ENSFHEP00000021238 | Chromo_2 domain-containing protein. (530 aa) |
| | ENSFHEP00000021240 | Uncharacterized protein. (215 aa) |
| | ENSFHEP00000021362 | Replication protein A2. (267 aa) |
| | shprh | SNF2 histone linker PHD RING helicase. (1651 aa) |
| | polh | Polymerase (DNA directed), eta. (721 aa) |
| | LOC105939822 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (388 aa) |
| | chtf18 | Chromosome transmission fidelity protein 18. (919 aa) |
| | rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (604 aa) |
| | poli | Polymerase (DNA directed) iota. (698 aa) |
| | MCMDC2 | Minichromosome maintenance domain containing 2. (645 aa) |
| | RAD23B | RAD23 homolog B, nucleotide excision repair protein. (387 aa) |
| | lig1 | DNA ligase. (742 aa) |
| | LOC105936901 | SCY domain-containing protein. (140 aa) |
| | rad1 | RAD1 homolog (S. pombe). (279 aa) |
| | orc4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa) |
| | rpl10a | Ribosomal protein; Belongs to the universal ribosomal protein uL1 family. (216 aa) |
| | nutf2 | Nuclear transport factor 2. (127 aa) |
| | topbp1 | DNA topoisomerase II binding protein 1. (1256 aa) |
| | rad9b | RAD9 checkpoint clamp component B. (400 aa) |
| | fancd2 | FA complementation group D2. (1376 aa) |
| | msh2 | MutS homolog 2 (E. coli). (524 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (693 aa) |
| | eme1 | Essential meiotic structure-specific endonuclease 1. (502 aa) |
| | MPHOSPH9 | M-phase phosphoprotein 9. (1263 aa) |
| | mcm3 | DNA helicase; Belongs to the MCM family. (767 aa) |
| | fbh1 | F-box DNA helicase 1. (1099 aa) |
| | rfc1 | Replication factor C subunit 1. (1161 aa) |
| | fanci | FA complementation group I. (1308 aa) |
| | dclre1a | DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae). (792 aa) |
| | brca1 | Breast cancer 1, early onset. (1357 aa) |
| | pold2 | Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa) |
| | LOC105919622 | DBF4-type domain-containing protein. (793 aa) |
| | recql4 | RecQ helicase-like 4. (1523 aa) |
| | mcm5 | DNA helicase; Belongs to the MCM family. (674 aa) |
| | pms1 | PMS1 homolog 1, mismatch repair system component. (807 aa) |
| | fan1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (967 aa) |
| | rev3l | REV3 like, DNA directed polymerase zeta catalytic subunit. (3019 aa) |
| | cdt1 | Chromatin licensing and DNA replication factor 1. (630 aa) |
| | piezo1 | Piezo-type mechanosensitive ion channel component. (2224 aa) |
| | fancf | FA complementation group F. (362 aa) |
| | wdr20 | Dystrophia myotonica WD repeat-containing protein. (598 aa) |
| | mcm4 | DNA helicase; Belongs to the MCM family. (868 aa) |
| | rev1 | REV1 DNA directed polymerase. (1353 aa) |
| | rfc2 | Replication factor C (activator 1) 2. (375 aa) |
| | faap24 | FA core complex associated protein 24. (214 aa) |
| | gmnn | Geminin DNA replication inhibitor. (266 aa) |
| | cdca7l | Cell division cycle associated 7b. (394 aa) |
| | xpa | Xeroderma pigmentosum, complementation group A. (275 aa) |
| | ENSFHEP00000029520 | Cell division cycle 7 homolog (S. cerevisiae); Belongs to the protein kinase superfamily. (382 aa) |
| | ENSFHEP00000029560 | Uncharacterized protein. (74 aa) |
| | mcmbp | Minichromosome maintenance complex binding protein. (584 aa) |
| | pold3 | Polymerase (DNA-directed), delta 3, accessory subunit. (290 aa) |
| | LOC110368405 | Uncharacterized protein. (158 aa) |
| | xpc | Xeroderma pigmentosum, complementation group C. (748 aa) |
| | ENSFHEP00000030190 | Uncharacterized protein. (81 aa) |
| | ercc5 | Excision repair cross-complementation group 5. (1094 aa) |
| | rad9a | Cell cycle checkpoint control protein; Belongs to the rad9 family. (416 aa) |
| | meiob | Methionine sulfoxide reductase B1b. (385 aa) |
| | chtf8 | CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (137 aa) |
| | chek1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (454 aa) |
| | ENSFHEP00000031592 | HATPase_c domain-containing protein. (112 aa) |
| | mlh3 | WW domain-containing protein. (374 aa) |
| | pif1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (631 aa) |
| | rpa3 | Replication protein A3. (122 aa) |
| | LOC105919224 | WD repeat domain 20b. (627 aa) |
| | nbn | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (820 aa) |
| | mcm6 | DNA helicase; Belongs to the MCM family. (824 aa) |
| | ENSFHEP00000032438 | Uncharacterized protein. (418 aa) |
| | usp46 | Ubiquitin carboxyl-terminal hydrolase 46; Belongs to the peptidase C19 family. (369 aa) |
| | ENSFHEP00000032645 | Si:cabz01080528.1. (602 aa) |
| | pms2 | PMS1 homolog 2, mismatch repair system component. (848 aa) |
| | gins4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (224 aa) |
| | rmi2 | RecQ mediated genome instability 2. (132 aa) |
| | DMWD | DM1 locus, WD repeat containing. (667 aa) |
| | rad52 | RAD52 homolog, DNA repair protein. (419 aa) |
| | LOC105933746 | MutS homolog 2 (E. coli). (469 aa) |
| | pold1 | DNA polymerase. (1152 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1037 aa) |
| | rfc4 | Replication factor C (activator 1) 4. (357 aa) |
| | top3b | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (858 aa) |
| | pcna | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa) |
| | ENSFHEP00000034851 | TAN domain-containing protein. (173 aa) |
