(43 nodes) RNA Polymerase II Transcription Elongation, and Assembly of the ORC complex at the origin of replication network (Fundulus heteroclitus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	polr2g	Polymerase (RNA) II (DNA directed) polypeptide G-like. (172 aa)
	paf1	PAF1 homolog, Paf1/RNA polymerase II complex component. (531 aa)
	supt6h	Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1751 aa)
	cinp	Cyclin-dependent kinase 2-interacting protein. (221 aa)
	polr2f	Polymerase (RNA) II (DNA directed) polypeptide F. (162 aa)
	polr2j	Polymerase (RNA) II (DNA directed) polypeptide J. (117 aa)
	ENSFHEP00000005843	Uncharacterized protein. (150 aa)
	ENSFHEP00000007488	RPOL4c domain-containing protein. (106 aa)
	supt4h1	Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II; Belongs to the SPT4 family. (117 aa)
	LOC105929958	Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family. (95 aa)
	LOC105916185	Histone H2B; Belongs to the histone H2B family. (124 aa)
	ENSFHEP00000008974	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
	ENSFHEP00000009416	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (94 aa)
	ENSFHEP00000009465	Histone H2A; Belongs to the histone H2A family. (137 aa)
	tceanc2	Uncharacterized protein. (214 aa)
	ENSFHEP00000011769	Histone H2A; Belongs to the histone H2A family. (139 aa)
	LOC105932629	POB3_N domain-containing protein. (104 aa)
	polr2b	Polymerase (RNA) II (DNA directed) polypeptide B; Belongs to the RNA polymerase beta chain family. (931 aa)
	tcea3	Transcription elongation factor A (SII), 3. (740 aa)
	polr2i	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (126 aa)
	LOC105916185-2	Histone H2B 1/2. (124 aa)
	LOC105933185	Histone H3; Belongs to the histone H3 family. (137 aa)
	srbd1	S1 RNA binding domain 1. (1017 aa)
	ENSFHEP00000017931	Uncharacterized protein. (59 aa)
	polr2a	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1916 aa)
	ENSFHEP00000022555	HMG box domain-containing protein. (144 aa)
	ENSFHEP00000022779	Uncharacterized protein. (211 aa)
	rtf1	RTF1 homolog, Paf1/RNA polymerase II complex component. (678 aa)
	ctr9	CTR9 homolog, Paf1/RNA polymerase II complex component. (1151 aa)
	leo1	LEO1 homolog, Paf1/RNA polymerase II complex component. (637 aa)
	ENSFHEP00000027007	Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family. (105 aa)
	ENSFHEP00000028115	Uncharacterized protein. (150 aa)
	supt5h	Transcription elongation factor SPT5. (1041 aa)
	tcea1	Transcription elongation factor A (SII), 1. (311 aa)
	cdc73	Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). (524 aa)
	ENSFHEP00000031253	Uncharacterized protein. (144 aa)
	polr2h	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
	eepd1	Endonuclease/exonuclease/phosphatase family domain containing 1. (556 aa)
	polr2l	Polymerase (RNA) II (DNA directed) polypeptide L. (67 aa)
	polr2c	Polymerase (RNA) II (DNA directed) polypeptide C. (275 aa)
	supt16h	SPT16 homolog, facilitates chromatin remodeling subunit. (1029 aa)
	iws1	TFIIS N-terminal domain-containing protein. (584 aa)
	LOC105926705	Histone H3.3. (136 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000005843	ENSFHEP00000007488	ENSFHEP00000005843	ENSFHEP00000007488	Uncharacterized protein.	RPOL4c domain-containing protein.	0.893
ENSFHEP00000005843	ENSFHEP00000008974	ENSFHEP00000005843	ENSFHEP00000008974	Uncharacterized protein.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.551
ENSFHEP00000005843	ENSFHEP00000009416	ENSFHEP00000005843	ENSFHEP00000009416	Uncharacterized protein.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.551
ENSFHEP00000005843	ENSFHEP00000009465	ENSFHEP00000005843	ENSFHEP00000009465	Uncharacterized protein.	Histone H2A; Belongs to the histone H2A family.	0.452
ENSFHEP00000005843	ENSFHEP00000011769	ENSFHEP00000005843	ENSFHEP00000011769	Uncharacterized protein.	Histone H2A; Belongs to the histone H2A family.	0.452
ENSFHEP00000005843	ENSFHEP00000017931	ENSFHEP00000005843	ENSFHEP00000017931	Uncharacterized protein.	Uncharacterized protein.	0.899
ENSFHEP00000005843	ENSFHEP00000022555	ENSFHEP00000005843	ENSFHEP00000022555	Uncharacterized protein.	HMG box domain-containing protein.	0.950
ENSFHEP00000005843	ENSFHEP00000022779	ENSFHEP00000005843	ENSFHEP00000022779	Uncharacterized protein.	Uncharacterized protein.	0.899
ENSFHEP00000005843	ENSFHEP00000027007	ENSFHEP00000005843	ENSFHEP00000027007	Uncharacterized protein.	Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family.	0.642
ENSFHEP00000005843	ENSFHEP00000028115	ENSFHEP00000005843	ENSFHEP00000028115	Uncharacterized protein.	Uncharacterized protein.	0.575
ENSFHEP00000005843	ENSFHEP00000031253	ENSFHEP00000005843	ENSFHEP00000031253	Uncharacterized protein.	Uncharacterized protein.	0.575
ENSFHEP00000005843	LOC105916185	ENSFHEP00000005843	ENSFHEP00000008963	Uncharacterized protein.	Histone H2B; Belongs to the histone H2B family.	0.665
ENSFHEP00000005843	LOC105916185-2	ENSFHEP00000005843	ENSFHEP00000015384	Uncharacterized protein.	Histone H2B 1/2.	0.665
ENSFHEP00000005843	LOC105926705	ENSFHEP00000005843	ENSFHEP00000035186	Uncharacterized protein.	Histone H3.3.	0.522
ENSFHEP00000005843	LOC105929958	ENSFHEP00000005843	ENSFHEP00000007959	Uncharacterized protein.	Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family.	0.642
ENSFHEP00000005843	LOC105932629	ENSFHEP00000005843	ENSFHEP00000013412	Uncharacterized protein.	POB3_N domain-containing protein.	0.950
ENSFHEP00000005843	LOC105933185	ENSFHEP00000005843	ENSFHEP00000016054	Uncharacterized protein.	Histone H3; Belongs to the histone H3 family.	0.522
ENSFHEP00000005843	cdc73	ENSFHEP00000005843	ENSFHEP00000030695	Uncharacterized protein.	Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae).	0.989
ENSFHEP00000005843	cinp	ENSFHEP00000005843	ENSFHEP00000003695	Uncharacterized protein.	Cyclin-dependent kinase 2-interacting protein.	0.963
ENSFHEP00000005843	ctr9	ENSFHEP00000005843	ENSFHEP00000025046	Uncharacterized protein.	CTR9 homolog, Paf1/RNA polymerase II complex component.	0.963