(23 nodes) Protein sumoylation, and Topoisomerase network (Fundulus heteroclitus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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	sae1	SUMO1 activating enzyme subunit 1. (384 aa)
	sumo2	Small ubiquitin-related modifier. (95 aa)
	uba2	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. (649 aa)
	kctd2	Potassium channel tetramerization domain containing 2. (270 aa)
	LOC105937167	Ubiquitin-like domain-containing protein. (133 aa)
	LOC105939042	Small ubiquitin like modifier 3. (158 aa)
	LOC105917640	SUMO specific peptidase 5. (249 aa)
	ENSFHEP00000010355	SP-RING-type domain-containing protein. (127 aa)
	ENSFHEP00000010603	ULP_PROTEASE domain-containing protein. (349 aa)
	pias4	Protein inhibitor of activated STAT, 4a. (497 aa)
	ENSFHEP00000012027	SUMO specific peptidase 6a. (455 aa)
	sumo1	Small ubiquitin-related modifier. (101 aa)
	top2b	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1605 aa)
	ENSFHEP00000019692	SAP domain-containing protein. (169 aa)
	nfatc2ip	Nuclear factor of activated T cells 2 interacting protein. (382 aa)
	ube2i	Ubiquitin-conjugating enzyme E2Ia; Belongs to the ubiquitin-conjugating enzyme family. (160 aa)
	LOC105928984	Sentrin-specific protease 1. (724 aa)
	LOC105936352	Protein inhibitor of activated STAT, 1a. (572 aa)
	LOC105933585	Small ubiquitin-related modifier. (96 aa)
	top2a	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1525 aa)
	LOC105926593	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (748 aa)
	LOC105916074	SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
	LOC105926097	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (766 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000010355	ENSFHEP00000019692	ENSFHEP00000010355	ENSFHEP00000019692	SP-RING-type domain-containing protein.	SAP domain-containing protein.	0.990
ENSFHEP00000010355	LOC105916074	ENSFHEP00000010355	ENSFHEP00000027147	SP-RING-type domain-containing protein.	SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family.	0.867
ENSFHEP00000010355	LOC105926097	ENSFHEP00000010355	ENSFHEP00000034532	SP-RING-type domain-containing protein.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.531
ENSFHEP00000010355	LOC105926593	ENSFHEP00000010355	ENSFHEP00000024702	SP-RING-type domain-containing protein.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.531
ENSFHEP00000010355	LOC105928984	ENSFHEP00000010355	ENSFHEP00000021210	SP-RING-type domain-containing protein.	Sentrin-specific protease 1.	0.427
ENSFHEP00000010355	LOC105933585	ENSFHEP00000010355	ENSFHEP00000023052	SP-RING-type domain-containing protein.	Small ubiquitin-related modifier.	0.835
ENSFHEP00000010355	LOC105936352	ENSFHEP00000010355	ENSFHEP00000022604	SP-RING-type domain-containing protein.	Protein inhibitor of activated STAT, 1a.	0.749
ENSFHEP00000010355	LOC105937167	ENSFHEP00000010355	ENSFHEP00000006742	SP-RING-type domain-containing protein.	Ubiquitin-like domain-containing protein.	0.835
ENSFHEP00000010355	LOC105939042	ENSFHEP00000010355	ENSFHEP00000008597	SP-RING-type domain-containing protein.	Small ubiquitin like modifier 3.	0.835
ENSFHEP00000010355	kctd2	ENSFHEP00000010355	ENSFHEP00000004044	SP-RING-type domain-containing protein.	Potassium channel tetramerization domain containing 2.	0.862
ENSFHEP00000010355	nfatc2ip	ENSFHEP00000010355	ENSFHEP00000020515	SP-RING-type domain-containing protein.	Nuclear factor of activated T cells 2 interacting protein.	0.720
ENSFHEP00000010355	pias4	ENSFHEP00000010355	ENSFHEP00000010914	SP-RING-type domain-containing protein.	Protein inhibitor of activated STAT, 4a.	0.913
ENSFHEP00000010355	sae1	ENSFHEP00000010355	ENSFHEP00000001537	SP-RING-type domain-containing protein.	SUMO1 activating enzyme subunit 1.	0.512
ENSFHEP00000010355	sumo1	ENSFHEP00000010355	ENSFHEP00000015878	SP-RING-type domain-containing protein.	Small ubiquitin-related modifier.	0.957
ENSFHEP00000010355	sumo2	ENSFHEP00000010355	ENSFHEP00000002112	SP-RING-type domain-containing protein.	Small ubiquitin-related modifier.	0.835
ENSFHEP00000010355	top2a	ENSFHEP00000010355	ENSFHEP00000024530	SP-RING-type domain-containing protein.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.663
ENSFHEP00000010355	top2b	ENSFHEP00000010355	ENSFHEP00000017208	SP-RING-type domain-containing protein.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.663
ENSFHEP00000010355	uba2	ENSFHEP00000010355	ENSFHEP00000003453	SP-RING-type domain-containing protein.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.509
ENSFHEP00000010355	ube2i	ENSFHEP00000010355	ENSFHEP00000021039	SP-RING-type domain-containing protein.	Ubiquitin-conjugating enzyme E2Ia; Belongs to the ubiquitin-conjugating enzyme family.	0.867
ENSFHEP00000010603	LOC105916074	ENSFHEP00000010603	ENSFHEP00000027147	ULP_PROTEASE domain-containing protein.	SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family.	0.481