(39 nodes) Mixed, incl. Calcineurin-mediated signaling, and Activation of RAC1 downstream of NMDARs network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105922020	Zgc:171704. (211 aa)
	tesc	Tescalcin a. (233 aa)
	ppp3r1	Uncharacterized protein. (170 aa)
	wdr92	WD repeat domain 92. (358 aa)
	LOC105915343	Calcineurin-like EF-hand protein 2. (194 aa)
	LOC105918732	RHD domain-containing protein. (879 aa)
	LOC105915293	Tescalcin b. (238 aa)
	ENSFHEP00000012387	Ig-like domain-containing protein. (127 aa)
	nfatc2	Nuclear factor of activated T cells 2a. (921 aa)
	ENSFHEP00000012835	EF-hand domain-containing protein. (73 aa)
	LOC105919313	Uncharacterized protein. (194 aa)
	ENSFHEP00000014387	Serine/threonine-protein phosphatase. (340 aa)
	LOC105929196	Serine/threonine-protein phosphatase. (501 aa)
	LOC105936533	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (822 aa)
	calm2	Calmodulin 2. (149 aa)
	nfatc4	Nuclear factor of activated T cells 4. (897 aa)
	rcan3	Regulator of calcineurin 3. (234 aa)
	LOC105931113	Serine/threonine-protein phosphatase. (511 aa)
	LOC105915460	Regulator of calcineurin 1a. (217 aa)
	LOC105933382	Uncharacterized protein. (847 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (224 aa)
	ENSFHEP00000026946	Uncharacterized protein. (72 aa)
	eef2k	Eukaryotic elongation factor 2 kinase. (623 aa)
	LOC110367401	Protein kinase domain-containing protein. (211 aa)
	LOC105927482	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (782 aa)
	LOC105918262	Calcium/calmodulin-dependent protein kinase IGb; Belongs to the protein kinase superfamily. (485 aa)
	trpv5	Transient receptor potential cation channel, subfamily V, member 6; Belongs to the transient receptor (TC 1.A.4) family. (728 aa)
	calml4	Calmodulin-like 4a. (153 aa)
	ENSFHEP00000030564	Uncharacterized protein. (75 aa)
	LOC105936550	Uncharacterized protein; Belongs to the calmodulin family. (207 aa)
	LOC105916905	Nuclear factor of activated T cells 1. (861 aa)
	camk1d	Calcium/calmodulin-dependent protein kinase ID, putative; Belongs to the protein kinase superfamily. (435 aa)
	LOC105934766	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (402 aa)
	LOC105930730	Hippocalcin-like 1. (239 aa)
	LOC105925607	Calmodulin. (149 aa)
	LOC105935895	CaM kinase-like vesicle-associated, like. (803 aa)
	LOC105935258	Peptidylprolyl isomerase. (168 aa)
	LOC105915415	Serine/threonine-protein phosphatase. (508 aa)
	LOC105920254	Peptidylprolyl isomerase. (107 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000012387	LOC105925607	ENSFHEP00000012387	ENSFHEP00000033933	Ig-like domain-containing protein.	Calmodulin.	0.521
ENSFHEP00000012387	LOC105936550	ENSFHEP00000012387	ENSFHEP00000030939	Ig-like domain-containing protein.	Uncharacterized protein; Belongs to the calmodulin family.	0.874
ENSFHEP00000012387	calm2	ENSFHEP00000012387	ENSFHEP00000018773	Ig-like domain-containing protein.	Calmodulin 2.	0.521
ENSFHEP00000012387	calml4	ENSFHEP00000012387	ENSFHEP00000030503	Ig-like domain-containing protein.	Calmodulin-like 4a.	0.780
ENSFHEP00000012835	ENSFHEP00000014387	ENSFHEP00000012835	ENSFHEP00000014387	EF-hand domain-containing protein.	Serine/threonine-protein phosphatase.	0.831
ENSFHEP00000012835	ENSFHEP00000026946	ENSFHEP00000012835	ENSFHEP00000026946	EF-hand domain-containing protein.	Uncharacterized protein.	0.841
ENSFHEP00000012835	ENSFHEP00000030564	ENSFHEP00000012835	ENSFHEP00000030564	EF-hand domain-containing protein.	Uncharacterized protein.	0.954
ENSFHEP00000012835	LOC105915415	ENSFHEP00000012835	ENSFHEP00000034968	EF-hand domain-containing protein.	Serine/threonine-protein phosphatase.	0.911
ENSFHEP00000012835	LOC105915460	ENSFHEP00000012835	ENSFHEP00000025749	EF-hand domain-containing protein.	Regulator of calcineurin 1a.	0.682
ENSFHEP00000012835	LOC105916905	ENSFHEP00000012835	ENSFHEP00000031023	EF-hand domain-containing protein.	Nuclear factor of activated T cells 1.	0.965
ENSFHEP00000012835	LOC105918732	ENSFHEP00000012835	ENSFHEP00000011418	EF-hand domain-containing protein.	RHD domain-containing protein.	0.923
ENSFHEP00000012835	LOC105920254	ENSFHEP00000012835	ENSFHEP00000035181	EF-hand domain-containing protein.	Peptidylprolyl isomerase.	0.696
ENSFHEP00000012835	LOC105925607	ENSFHEP00000012835	ENSFHEP00000033933	EF-hand domain-containing protein.	Calmodulin.	0.676
ENSFHEP00000012835	LOC105927482	ENSFHEP00000012835	ENSFHEP00000028642	EF-hand domain-containing protein.	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.635
ENSFHEP00000012835	LOC105929196	ENSFHEP00000012835	ENSFHEP00000014571	EF-hand domain-containing protein.	Serine/threonine-protein phosphatase.	0.911
ENSFHEP00000012835	LOC105931113	ENSFHEP00000012835	ENSFHEP00000025719	EF-hand domain-containing protein.	Serine/threonine-protein phosphatase.	0.911
ENSFHEP00000012835	LOC105933382	ENSFHEP00000012835	ENSFHEP00000025920	EF-hand domain-containing protein.	Uncharacterized protein.	0.965
ENSFHEP00000012835	LOC105935258	ENSFHEP00000012835	ENSFHEP00000034926	EF-hand domain-containing protein.	Peptidylprolyl isomerase.	0.699
ENSFHEP00000012835	LOC105936533	ENSFHEP00000012835	ENSFHEP00000016143	EF-hand domain-containing protein.	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.635
ENSFHEP00000012835	LOC105936550	ENSFHEP00000012835	ENSFHEP00000030939	EF-hand domain-containing protein.	Uncharacterized protein; Belongs to the calmodulin family.	0.750