(24 nodes) PDGF/VEGF domain, and Tyrosine-protein kinase, receptor class III, conserved site network (Fundulus heteroclitus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	pdgfd	Platelet derived growth factor d. (363 aa)
	LOC105916745	KIT proto-oncogene, receptor tyrosine kinase b; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (905 aa)
	LOC105931176	Hepatocyte growth factor a; Belongs to the peptidase S1 family. Plasminogen subfamily. (714 aa)
	pdgfc	Platelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family. (391 aa)
	LOC105918269	Platelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family. (228 aa)
	flt4	Vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1390 aa)
	pir	Pirin; Belongs to the pirin family. (271 aa)
	kitlg	Kit ligand a. (266 aa)
	LOC105915406	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (561 aa)
	kit	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (937 aa)
	pdgfrb	Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1020 aa)
	vegfb	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (256 aa)
	LOC105925783	Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1331 aa)
	flt1	Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1273 aa)
	pgf	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (136 aa)
	LOC105921022	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (199 aa)
	ENSFHEP00000016700	Uncharacterized protein. (287 aa)
	pdgfra	Platelet-derived growth factor receptor, alpha polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (987 aa)
	LOC105933547	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (523 aa)
	angpt2	Angiopoietin 2a. (491 aa)
	vegfa	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
	ENSFHEP00000026972	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (268 aa)
	kdr	Receptor protein-tyrosine kinase. (1123 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000016700	LOC105916745	ENSFHEP00000016700	ENSFHEP00000003018	Uncharacterized protein.	KIT proto-oncogene, receptor tyrosine kinase b; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.967
ENSFHEP00000016700	LOC105925783	ENSFHEP00000016700	ENSFHEP00000014174	Uncharacterized protein.	Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.909
ENSFHEP00000016700	flt1	ENSFHEP00000016700	ENSFHEP00000014928	Uncharacterized protein.	Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.906
ENSFHEP00000016700	flt4	ENSFHEP00000016700	ENSFHEP00000007876	Uncharacterized protein.	Vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.909
ENSFHEP00000016700	kdr	ENSFHEP00000016700	ENSFHEP00000029299	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.909
ENSFHEP00000016700	kit	ENSFHEP00000016700	ENSFHEP00000012472	Uncharacterized protein.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.967
ENSFHEP00000016700	kitlg	ENSFHEP00000016700	ENSFHEP00000009095	Uncharacterized protein.	Kit ligand a.	0.955
ENSFHEP00000016700	pdgfra	ENSFHEP00000016700	ENSFHEP00000017471	Uncharacterized protein.	Platelet-derived growth factor receptor, alpha polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.907
ENSFHEP00000016700	pdgfrb	ENSFHEP00000016700	ENSFHEP00000012823	Uncharacterized protein.	Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.904
ENSFHEP00000026972	LOC105915406	ENSFHEP00000026972	ENSFHEP00000009160	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family.	0.743
ENSFHEP00000026972	LOC105916745	ENSFHEP00000026972	ENSFHEP00000003018	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	KIT proto-oncogene, receptor tyrosine kinase b; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.920
ENSFHEP00000026972	LOC105918269	ENSFHEP00000026972	ENSFHEP00000007644	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	Platelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family.	0.767
ENSFHEP00000026972	LOC105921022	ENSFHEP00000026972	ENSFHEP00000015844	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.767
ENSFHEP00000026972	LOC105925783	ENSFHEP00000026972	ENSFHEP00000014174	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.946
ENSFHEP00000026972	LOC105931176	ENSFHEP00000026972	ENSFHEP00000003172	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	Hepatocyte growth factor a; Belongs to the peptidase S1 family. Plasminogen subfamily.	0.760
ENSFHEP00000026972	LOC105933547	ENSFHEP00000026972	ENSFHEP00000024231	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family.	0.743
ENSFHEP00000026972	flt1	ENSFHEP00000026972	ENSFHEP00000014928	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.924
ENSFHEP00000026972	flt4	ENSFHEP00000026972	ENSFHEP00000007876	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	Vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.946
ENSFHEP00000026972	kdr	ENSFHEP00000026972	ENSFHEP00000029299	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	Receptor protein-tyrosine kinase.	0.946
ENSFHEP00000026972	kit	ENSFHEP00000026972	ENSFHEP00000012472	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.920