STRINGSTRING
rapgef5 rapgef5 foxo3 foxo3 ralgps2 ralgps2 LOC105921984 LOC105921984 FOXO3 FOXO3 deptor deptor RASA2 RASA2 ENSFHEP00000001710 ENSFHEP00000001710 DIRAS1 DIRAS1 LOC105939768 LOC105939768 rptor rptor REM1 REM1 map2k5 map2k5 LOC105933560 LOC105933560 LOC105931838 LOC105931838 LOC105932227 LOC105932227 LOC105938003 LOC105938003 sos2 sos2 ralbp1 ralbp1 mras mras ENSFHEP00000004183 ENSFHEP00000004183 akt1s1 akt1s1 arhgef12 arhgef12 rps6ka3 rps6ka3 LOC105927659 LOC105927659 mlf1 mlf1 SGK1 SGK1 LOC105932864 LOC105932864 LOC105936241 LOC105936241 rasa1 rasa1 LOC105927128 LOC105927128 kras kras LOC105919467 LOC105919467 LOC105929954 LOC105929954 prkcq prkcq tsc2 tsc2 rasa3 rasa3 SPRED2 SPRED2 ENSFHEP00000009730 ENSFHEP00000009730 ENSFHEP00000009767 ENSFHEP00000009767 ENSFHEP00000010577 ENSFHEP00000010577 ENSFHEP00000010588 ENSFHEP00000010588 ENSFHEP00000010757 ENSFHEP00000010757 map2k2 map2k2 shoc2 shoc2 mapk1 mapk1 foxo1 foxo1 LOC105917003 LOC105917003 LOC105915280 LOC105915280 LOC105936050 LOC105936050 LOC105919299 LOC105919299 gem gem LOC105929167 LOC105929167 rap2c rap2c LOC105927446 LOC105927446 LOC105931522 LOC105931522 mlst8 mlst8 LOC105936007 LOC105936007 ENSFHEP00000015557 ENSFHEP00000015557 ENSFHEP00000015671 ENSFHEP00000015671 RAP2B RAP2B rragc rragc rapgef2 rapgef2 ywhaz ywhaz prmt1 prmt1 LOC105927955 LOC105927955 LOC105921509 LOC105921509 spred1 spred1 LOC105939921 LOC105939921 LOC105935263 LOC105935263 ywhae ywhae CRYBB3 CRYBB3 ENSFHEP00000020509 ENSFHEP00000020509 LOC105933629 LOC105933629 LOC105921540 LOC105921540 LOC105934698 LOC105934698 pdpk1 pdpk1 map3k3 map3k3 rap1gap2 rap1gap2 LOC105940337 LOC105940337 LOC105921976 LOC105921976 rgl1 rgl1 garnl3 garnl3 LOC105919602 LOC105919602 LOC105931232 LOC105931232 LOC105918998 LOC105918998 ksr1 ksr1 nf1 nf1 raf1 raf1 LOC105929409 LOC105929409 ENSFHEP00000022685 ENSFHEP00000022685 YWHAB YWHAB rheb rheb LOC105924144 LOC105924144 ksr2 ksr2 LOC105926005 LOC105926005 ppp1cc ppp1cc map2k1 map2k1 prkce prkce LOC105927645 LOC105927645 prkcd prkcd sirt1 sirt1 prkch prkch akt1 akt1 LOC105929964 LOC105929964 LOC105917719 LOC105917719 hras hras cd28 cd28 CSDE1 CSDE1 LOC105931058 LOC105931058 rictor rictor ENSFHEP00000028059 ENSFHEP00000028059 ENSFHEP00000028107 ENSFHEP00000028107 LOC105939538 LOC105939538 LOC105930955 LOC105930955 RASGEF1B RASGEF1B RASGEF1C RASGEF1C RAPGEF5 RAPGEF5 LOC105923094 LOC105923094 foxo4 foxo4 rps6kb1 rps6kb1 RPS6KB2 RPS6KB2 elavl1 elavl1 LOC105928040 LOC105928040 ENSFHEP00000031550 ENSFHEP00000031550 pkn2 pkn2 ENSFHEP00000031565 ENSFHEP00000031565 rap2b rap2b LOC105928010 LOC105928010 braf braf LOC105922981 LOC105922981 LOC105939687 LOC105939687 brap brap ENSFHEP00000033928 ENSFHEP00000033928 LOC105915654 LOC105915654 ENSFHEP00000034505 ENSFHEP00000034505 cby1 cby1 sgk2 sgk2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rapgef5Rap guanine nucleotide exchange factor (GEF) 5a. (864 aa)
foxo3Forkhead box protein O3. (668 aa)
ralgps2Ral GEF with PH domain and SH3 binding motif 2. (527 aa)
LOC105921984Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (422 aa)
FOXO3Forkhead box O3. (612 aa)
deptorDEP domain containing MTOR-interacting protein. (404 aa)
RASA2RAS p21 protein activator 2. (816 aa)
ENSFHEP00000001710DEP domain-containing protein. (103 aa)
DIRAS1DIRAS family GTPase 1. (199 aa)
LOC105939768Protein kinase N1a. (739 aa)
rptorRegulatory associated protein of MTOR, complex 1. (1250 aa)
REM1RRAD and GEM like GTPase 1. (307 aa)
map2k5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (444 aa)
LOC105933560Rasd family member 4. (208 aa)
LOC105931838Uncharacterized protein; Belongs to the beta/gamma-crystallin family. (257 aa)
LOC105932227Crystallin, gamma N1; Belongs to the beta/gamma-crystallin family. (183 aa)
LOC105938003Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (486 aa)
sos2Son of sevenless homolog 2 (Drosophila). (1323 aa)
ralbp1RalA binding protein 1. (663 aa)
mrasMuscle RAS oncogene homolog. (208 aa)
ENSFHEP00000004183Protein kinase domain-containing protein. (925 aa)
akt1s1AKT1 substrate 1 (proline-rich). (353 aa)
arhgef12Rho guanine nucleotide exchange factor (GEF) 12a. (1411 aa)
rps6ka3Non-specific serine/threonine protein kinase. (690 aa)
LOC105927659Ribosomal protein S6 kinase. (770 aa)
mlf1Myeloid leukemia factor 1. (273 aa)
SGK1Serine/threonine-protein kinase Sgk1; Protein kinase that may play an important role in cellular stress response. May be involved in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion (By similarity); Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (439 aa)
LOC105932864TBC1 domain family, member 7. (294 aa)
LOC105936241V-ral simian leukemia viral oncogene homolog Ba (ras related). (207 aa)
rasa1RAS p21 protein activator (GTPase activating protein) 1a. (1052 aa)
LOC105927128Ras homolog, mTORC1 binding like 1. (184 aa)
krasV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
LOC105919467TSC complex subunit 1. (1034 aa)
LOC105929954Uncharacterized protein. (743 aa)
prkcqProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
tsc2TSC complex subunit 2. (1700 aa)
rasa3Ras GTPase-activating protein 3. (869 aa)
SPRED2Sprouty related EVH1 domain containing 2. (493 aa)
ENSFHEP00000009730Uncharacterized protein. (286 aa)
ENSFHEP00000009767RAS protein activator like 2. (842 aa)
ENSFHEP00000010577Protein kinase domain-containing protein. (121 aa)
ENSFHEP00000010588Protein kinase domain-containing protein. (239 aa)
ENSFHEP00000010757Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (447 aa)
map2k2Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (399 aa)
shoc2SHOC2 leucine rich repeat scaffold protein. (523 aa)
mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
foxo1Forkhead box O1 a. (672 aa)
LOC1059170033-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2; Belongs to the 14-3-3 family. (247 aa)
LOC105915280Uncharacterized protein; Belongs to the protein kinase superfamily. (417 aa)
LOC105936050Ral guanine nucleotide dissociation stimulator-like 2. (740 aa)
LOC105919299Sprouty related EVH1 domain containing 2a. (432 aa)
gemGTP binding protein overexpressed in skeletal muscle. (306 aa)
LOC105929167Ribosomal protein S6 kinase. (727 aa)
rap2cRAP2C, member of RAS oncogene family. (183 aa)
LOC105927446TSC complex subunit 1b. (1254 aa)
LOC105931522Ral guanine nucleotide dissociation stimulator-like 3a. (784 aa)
mlst8MTOR associated protein, LST8 homolog (S. cerevisiae). (334 aa)
LOC105936007Uncharacterized protein. (207 aa)
ENSFHEP00000015557Uncharacterized protein. (588 aa)
ENSFHEP00000015671CRIM domain-containing protein. (137 aa)
RAP2BUncharacterized protein. (155 aa)
rragcRas-related GTP binding Ca. (262 aa)
rapgef2Rap guanine nucleotide exchange factor (GEF) 2. (1626 aa)
ywhaz14-3-3.a protein; Belongs to the 14-3-3 family. (247 aa)
prmt1Protein arginine N-methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
LOC105927955Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC105921509Ras-related protein Rap-2c. (247 aa)
spred1Sprouty related EVH1 domain containing 1. (439 aa)
LOC105939921Zgc:55558. (187 aa)
LOC105935263RAP1 GTPase activating protein. (673 aa)
ywhae14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa)
CRYBB3Crystallin beta B3; Belongs to the beta/gamma-crystallin family. (323 aa)
ENSFHEP0000002050914_3_3 domain-containing protein; Belongs to the 14-3-3 family. (168 aa)
LOC105933629Uncharacterized protein. (183 aa)
LOC105921540Zgc:110699. (202 aa)
LOC105934698Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (532 aa)
pdpk13-phosphoinositide dependent protein kinase 1b. (563 aa)
map3k3Mitogen-activated protein kinase kinase kinase 3. (617 aa)
rap1gap2RAP1 GTPase activating protein 2a. (732 aa)
LOC105940337Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (485 aa)
LOC105921976Forkhead box O6 b. (740 aa)
rgl1Ral guanine nucleotide dissociation stimulator-like 1. (813 aa)
garnl3GTPase activating Rap/RanGAP domain like 3. (1033 aa)
LOC105919602Si:dkeyp-97e7.9. (313 aa)
LOC105931232Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC105918998V-ral simian leukemia viral oncogene homolog Aa (ras related). (206 aa)
ksr1Kinase suppressor of ras 1a. (1299 aa)
nf1Neurofibromin 1b. (2547 aa)
raf1RAF proto-oncogene serine/threonine-protein kinase. (671 aa)
LOC105929409Fork-head domain-containing protein. (643 aa)
ENSFHEP00000022685Ribosomal protein S6 kinase related a. (219 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b; Belongs to the 14-3-3 family. (260 aa)
rhebRas homolog, mTORC1 binding. (183 aa)
LOC105924144Ras-GEF domain-containing protein. (317 aa)
ksr2Kinase suppressor of ras 2. (895 aa)
LOC105926005Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (683 aa)
ppp1ccSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (361 aa)
map2k1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
prkceProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (767 aa)
LOC105927645Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b; Belongs to the 14-3-3 family. (249 aa)
prkcdProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (685 aa)
sirt1Sirtuin 1. (719 aa)
prkchProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (678 aa)
akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
LOC105929964Protein kinase N1b. (961 aa)
LOC105917719DIRAS family, GTP-binding RAS-like 1b. (200 aa)
hrasHRas proto-oncogene, GTPase a. (189 aa)
cd28CD28 molecule. (243 aa)
CSDE1Cold shock domain containing E1, RNA-binding. (870 aa)
LOC10593105814-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (244 aa)
rictorRPTOR independent companion of MTOR, complex 2 a. (1659 aa)
ENSFHEP00000028059C2 domain-containing protein. (147 aa)
ENSFHEP00000028107Uncharacterized protein. (82 aa)
LOC105939538Forkhead box O6 a. (721 aa)
LOC105930955RasGEF domain family, member 1Bb. (473 aa)
RASGEF1BRasGEF domain family member 1B. (537 aa)
RASGEF1CRasGEF domain family member 1C. (537 aa)
RAPGEF5Uncharacterized protein. (492 aa)
LOC105923094ELAV-like protein; Belongs to the RRM elav family. (314 aa)
foxo4Forkhead box O4. (634 aa)
rps6kb1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (509 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (471 aa)
elavl1ELAV-like protein; Belongs to the RRM elav family. (348 aa)
LOC105928040Rap-GAP domain-containing protein. (628 aa)
ENSFHEP00000031550MAPK associated protein 1. (441 aa)
pkn2Protein kinase N2. (988 aa)
ENSFHEP00000031565Protein kinase domain-containing protein. (105 aa)
rap2bRAP2B, member of RAS oncogene family. (183 aa)
LOC10592801014_3_3 domain-containing protein; Belongs to the 14-3-3 family. (247 aa)
brafB-Raf proto-oncogene, serine/threonine kinase. (773 aa)
LOC105922981Uncharacterized protein. (214 aa)
LOC105939687RAS related. (185 aa)
brapBRCA1 associated protein. (586 aa)
ENSFHEP00000033928Si:ch211-168d1.3. (619 aa)
LOC105915654A-Raf proto-oncogene, serine/threonine kinase. (603 aa)
ENSFHEP00000034505Tankyrase_bdg_C domain-containing protein. (354 aa)
cby1Chibby homolog 1 (Drosophila). (125 aa)
sgk2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (361 aa)
Your Current Organism:
Fundulus heteroclitus
NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog
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