85 items (Fundulus heteroclitus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rapgef5	Rap guanine nucleotide exchange factor (GEF) 5a. (864 aa)
	RASA2	RAS p21 protein activator 2. (816 aa)
	DIRAS1	DIRAS family GTPase 1. (199 aa)
	LOC105939768	Protein kinase N1a. (739 aa)
	REM1	RRAD and GEM like GTPase 1. (307 aa)
	map2k5	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (444 aa)
	LOC105933560	Rasd family member 4. (208 aa)
	sos2	Son of sevenless homolog 2 (Drosophila). (1323 aa)
	ralbp1	RalA binding protein 1. (663 aa)
	mras	Muscle RAS oncogene homolog. (208 aa)
	ENSFHEP00000004183	Protein kinase domain-containing protein. (925 aa)
	arhgef12	Rho guanine nucleotide exchange factor (GEF) 12a. (1411 aa)
	mlf1	Myeloid leukemia factor 1. (273 aa)
	LOC105936241	V-ral simian leukemia viral oncogene homolog Ba (ras related). (207 aa)
	rasa1	RAS p21 protein activator (GTPase activating protein) 1a. (1052 aa)
	kras	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	LOC105929954	Uncharacterized protein. (743 aa)
	prkcq	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
	rasa3	Ras GTPase-activating protein 3. (869 aa)
	SPRED2	Sprouty related EVH1 domain containing 2. (493 aa)
	ENSFHEP00000009730	Uncharacterized protein. (286 aa)
	ENSFHEP00000009767	RAS protein activator like 2. (842 aa)
	ENSFHEP00000010577	Protein kinase domain-containing protein. (121 aa)
	ENSFHEP00000010588	Protein kinase domain-containing protein. (239 aa)
	ENSFHEP00000010757	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (447 aa)
	map2k2	Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (399 aa)
	shoc2	SHOC2 leucine rich repeat scaffold protein. (523 aa)
	mapk1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
	LOC105917003	3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2; Belongs to the 14-3-3 family. (247 aa)
	LOC105936050	Ral guanine nucleotide dissociation stimulator-like 2. (740 aa)
	LOC105919299	Sprouty related EVH1 domain containing 2a. (432 aa)
	gem	GTP binding protein overexpressed in skeletal muscle. (306 aa)
	LOC105931522	Ral guanine nucleotide dissociation stimulator-like 3a. (784 aa)
	LOC105936007	Uncharacterized protein. (207 aa)
	ENSFHEP00000015557	Uncharacterized protein. (588 aa)
	RAP2B	Uncharacterized protein. (155 aa)
	ywhaz	14-3-3.a protein; Belongs to the 14-3-3 family. (247 aa)
	LOC105921509	Ras-related protein Rap-2c. (247 aa)
	spred1	Sprouty related EVH1 domain containing 1. (439 aa)
	LOC105939921	Zgc:55558. (187 aa)
	LOC105935263	RAP1 GTPase activating protein. (673 aa)
	ywhae	14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa)
	ENSFHEP00000020509	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (168 aa)
	LOC105933629	Uncharacterized protein. (183 aa)
	map3k3	Mitogen-activated protein kinase kinase kinase 3. (617 aa)
	rap1gap2	RAP1 GTPase activating protein 2a. (732 aa)
	rgl1	Ral guanine nucleotide dissociation stimulator-like 1. (813 aa)
	LOC105918998	V-ral simian leukemia viral oncogene homolog Aa (ras related). (206 aa)
	ksr1	Kinase suppressor of ras 1a. (1299 aa)
	nf1	Neurofibromin 1b. (2547 aa)
	raf1	RAF proto-oncogene serine/threonine-protein kinase. (671 aa)
	ENSFHEP00000022685	Ribosomal protein S6 kinase related a. (219 aa)
	YWHAB	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b; Belongs to the 14-3-3 family. (260 aa)
	LOC105924144	Ras-GEF domain-containing protein. (317 aa)
	ksr2	Kinase suppressor of ras 2. (895 aa)
	LOC105926005	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (683 aa)
	ppp1cc	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (361 aa)
	map2k1	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
	prkce	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (767 aa)
	LOC105927645	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b; Belongs to the 14-3-3 family. (249 aa)
	prkcd	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (685 aa)
	prkch	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (678 aa)
	LOC105929964	Protein kinase N1b. (961 aa)
	LOC105917719	DIRAS family, GTP-binding RAS-like 1b. (200 aa)
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	cd28	CD28 molecule. (243 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (870 aa)
	LOC105931058	14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (244 aa)
	ENSFHEP00000028059	C2 domain-containing protein. (147 aa)
	ENSFHEP00000028107	Uncharacterized protein. (82 aa)
	RAPGEF5	Uncharacterized protein. (492 aa)
	LOC105923094	ELAV-like protein; Belongs to the RRM elav family. (314 aa)
	elavl1	ELAV-like protein; Belongs to the RRM elav family. (348 aa)
	LOC105928040	Rap-GAP domain-containing protein. (628 aa)
	pkn2	Protein kinase N2. (988 aa)
	ENSFHEP00000031565	Protein kinase domain-containing protein. (105 aa)
	rap2b	RAP2B, member of RAS oncogene family. (183 aa)
	LOC105928010	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (247 aa)
	braf	B-Raf proto-oncogene, serine/threonine kinase. (773 aa)
	LOC105922981	Uncharacterized protein. (214 aa)
	LOC105939687	RAS related. (185 aa)
	brap	BRCA1 associated protein. (586 aa)
	ENSFHEP00000033928	Si:ch211-168d1.3. (619 aa)
	LOC105915654	A-Raf proto-oncogene, serine/threonine kinase. (603 aa)
	cby1	Chibby homolog 1 (Drosophila). (125 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	ENSFHEP00000004183	ENSFHEP00000027279	ENSFHEP00000004183	Cold shock domain containing E1, RNA-binding.	Protein kinase domain-containing protein.	0.568
CSDE1	ENSFHEP00000009730	ENSFHEP00000027279	ENSFHEP00000009730	Cold shock domain containing E1, RNA-binding.	Uncharacterized protein.	0.586
CSDE1	ENSFHEP00000009767	ENSFHEP00000027279	ENSFHEP00000009767	Cold shock domain containing E1, RNA-binding.	RAS protein activator like 2.	0.586
CSDE1	ENSFHEP00000010577	ENSFHEP00000027279	ENSFHEP00000010577	Cold shock domain containing E1, RNA-binding.	Protein kinase domain-containing protein.	0.582
CSDE1	ENSFHEP00000010588	ENSFHEP00000027279	ENSFHEP00000010588	Cold shock domain containing E1, RNA-binding.	Protein kinase domain-containing protein.	0.582
CSDE1	ENSFHEP00000020509	ENSFHEP00000027279	ENSFHEP00000020509	Cold shock domain containing E1, RNA-binding.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.438
CSDE1	ENSFHEP00000028059	ENSFHEP00000027279	ENSFHEP00000028059	Cold shock domain containing E1, RNA-binding.	C2 domain-containing protein.	0.582
CSDE1	ENSFHEP00000028107	ENSFHEP00000027279	ENSFHEP00000028107	Cold shock domain containing E1, RNA-binding.	Uncharacterized protein.	0.783
CSDE1	ENSFHEP00000031565	ENSFHEP00000027279	ENSFHEP00000031565	Cold shock domain containing E1, RNA-binding.	Protein kinase domain-containing protein.	0.568
CSDE1	ENSFHEP00000033928	ENSFHEP00000027279	ENSFHEP00000033928	Cold shock domain containing E1, RNA-binding.	Si:ch211-168d1.3.	0.830
CSDE1	LOC105915654	ENSFHEP00000027279	ENSFHEP00000034440	Cold shock domain containing E1, RNA-binding.	A-Raf proto-oncogene, serine/threonine kinase.	0.835
CSDE1	LOC105917003	ENSFHEP00000027279	ENSFHEP00000012097	Cold shock domain containing E1, RNA-binding.	3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2; Belongs to the 14-3-3 family.	0.438
CSDE1	LOC105919299	ENSFHEP00000027279	ENSFHEP00000012905	Cold shock domain containing E1, RNA-binding.	Sprouty related EVH1 domain containing 2a.	0.677
CSDE1	LOC105924144	ENSFHEP00000027279	ENSFHEP00000023266	Cold shock domain containing E1, RNA-binding.	Ras-GEF domain-containing protein.	0.783
CSDE1	LOC105926005	ENSFHEP00000027279	ENSFHEP00000023903	Cold shock domain containing E1, RNA-binding.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.653
CSDE1	LOC105927645	ENSFHEP00000027279	ENSFHEP00000025008	Cold shock domain containing E1, RNA-binding.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b; Belongs to the 14-3-3 family.	0.455
CSDE1	LOC105928010	ENSFHEP00000027279	ENSFHEP00000031957	Cold shock domain containing E1, RNA-binding.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.438
CSDE1	LOC105928040	ENSFHEP00000027279	ENSFHEP00000030944	Cold shock domain containing E1, RNA-binding.	Rap-GAP domain-containing protein.	0.568
CSDE1	LOC105929954	ENSFHEP00000027279	ENSFHEP00000008099	Cold shock domain containing E1, RNA-binding.	Uncharacterized protein.	0.594
CSDE1	LOC105931058	ENSFHEP00000027279	ENSFHEP00000027305	Cold shock domain containing E1, RNA-binding.	14-3-3 protein zeta/delta; Belongs to the 14-3-3 family.	0.455