(38 nodes) Mixed, incl. 14-3-3 domain, and Calcium-dependent protein kinase C activity network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105939768	Protein kinase N1a. (739 aa)
	REM1	RRAD and GEM like GTPase 1. (307 aa)
	map2k5	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (444 aa)
	ENSFHEP00000004183	Protein kinase domain-containing protein. (925 aa)
	mlf1	Myeloid leukemia factor 1. (273 aa)
	kras	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	ENSFHEP00000010577	Protein kinase domain-containing protein. (121 aa)
	ENSFHEP00000010588	Protein kinase domain-containing protein. (239 aa)
	ENSFHEP00000010757	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (447 aa)
	map2k2	Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (399 aa)
	mapk1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
	LOC105917003	3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2; Belongs to the 14-3-3 family. (247 aa)
	LOC105936007	Uncharacterized protein. (207 aa)
	ENSFHEP00000015557	Uncharacterized protein. (588 aa)
	ywhaz	14-3-3.a protein; Belongs to the 14-3-3 family. (247 aa)
	ywhae	14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa)
	ENSFHEP00000020509	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (168 aa)
	map3k3	Mitogen-activated protein kinase kinase kinase 3. (617 aa)
	ksr1	Kinase suppressor of ras 1a. (1299 aa)
	raf1	RAF proto-oncogene serine/threonine-protein kinase. (671 aa)
	ENSFHEP00000022685	Ribosomal protein S6 kinase related a. (219 aa)
	YWHAB	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b; Belongs to the 14-3-3 family. (260 aa)
	ksr2	Kinase suppressor of ras 2. (895 aa)
	map2k1	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
	prkce	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (767 aa)
	LOC105927645	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b; Belongs to the 14-3-3 family. (249 aa)
	prkch	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (678 aa)
	LOC105929964	Protein kinase N1b. (961 aa)
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	LOC105931058	14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (244 aa)
	ENSFHEP00000028059	C2 domain-containing protein. (147 aa)
	pkn2	Protein kinase N2. (988 aa)
	ENSFHEP00000031565	Protein kinase domain-containing protein. (105 aa)
	LOC105928010	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (247 aa)
	braf	B-Raf proto-oncogene, serine/threonine kinase. (773 aa)
	brap	BRCA1 associated protein. (586 aa)
	LOC105915654	A-Raf proto-oncogene, serine/threonine kinase. (603 aa)
	cby1	Chibby homolog 1 (Drosophila). (125 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000004183	ENSFHEP00000010577	ENSFHEP00000004183	ENSFHEP00000010577	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.637
ENSFHEP00000004183	ENSFHEP00000010588	ENSFHEP00000004183	ENSFHEP00000010588	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.637
ENSFHEP00000004183	ENSFHEP00000010757	ENSFHEP00000004183	ENSFHEP00000010757	Protein kinase domain-containing protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.661
ENSFHEP00000004183	ENSFHEP00000015557	ENSFHEP00000004183	ENSFHEP00000015557	Protein kinase domain-containing protein.	Uncharacterized protein.	0.637
ENSFHEP00000004183	ENSFHEP00000022685	ENSFHEP00000004183	ENSFHEP00000022685	Protein kinase domain-containing protein.	Ribosomal protein S6 kinase related a.	0.515
ENSFHEP00000004183	ENSFHEP00000028059	ENSFHEP00000004183	ENSFHEP00000028059	Protein kinase domain-containing protein.	C2 domain-containing protein.	0.637
ENSFHEP00000004183	LOC105929964	ENSFHEP00000004183	ENSFHEP00000026677	Protein kinase domain-containing protein.	Protein kinase N1b.	0.637
ENSFHEP00000004183	LOC105936007	ENSFHEP00000004183	ENSFHEP00000014539	Protein kinase domain-containing protein.	Uncharacterized protein.	0.568
ENSFHEP00000004183	LOC105939768	ENSFHEP00000004183	ENSFHEP00000002045	Protein kinase domain-containing protein.	Protein kinase N1a.	0.637
ENSFHEP00000004183	REM1	ENSFHEP00000004183	ENSFHEP00000002248	Protein kinase domain-containing protein.	RRAD and GEM like GTPase 1.	0.494
ENSFHEP00000004183	hras	ENSFHEP00000004183	ENSFHEP00000026925	Protein kinase domain-containing protein.	HRas proto-oncogene, GTPase a.	0.568
ENSFHEP00000004183	kras	ENSFHEP00000004183	ENSFHEP00000007955	Protein kinase domain-containing protein.	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog.	0.568
ENSFHEP00000004183	map2k1	ENSFHEP00000004183	ENSFHEP00000023976	Protein kinase domain-containing protein.	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	0.828
ENSFHEP00000004183	map2k2	ENSFHEP00000004183	ENSFHEP00000010959	Protein kinase domain-containing protein.	Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily.	0.828
ENSFHEP00000004183	map2k5	ENSFHEP00000004183	ENSFHEP00000002285	Protein kinase domain-containing protein.	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily.	0.828
ENSFHEP00000004183	mapk1	ENSFHEP00000004183	ENSFHEP00000011839	Protein kinase domain-containing protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.503
ENSFHEP00000004183	pkn2	ENSFHEP00000004183	ENSFHEP00000031552	Protein kinase domain-containing protein.	Protein kinase N2.	0.637
ENSFHEP00000004183	prkce	ENSFHEP00000004183	ENSFHEP00000024878	Protein kinase domain-containing protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.637
ENSFHEP00000004183	prkch	ENSFHEP00000004183	ENSFHEP00000025650	Protein kinase domain-containing protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.637
ENSFHEP00000010577	ENSFHEP00000004183	ENSFHEP00000010577	ENSFHEP00000004183	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.637