(24 nodes) Cell killing network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PRF1	Perforin 1. (582 aa)
	tusc2	Tumor suppressor 2, mitochondrial calcium regulator. (101 aa)
	LOC105932611	Uncharacterized protein. (308 aa)
	LOC105929155	SH2 domain containing 1A duplicate b. (156 aa)
	LOC105928180	CC chemokine SCYA116. (106 aa)
	RPL30	Ribosomal protein L30. (95 aa)
	LOC105931538	Uncharacterized protein. (461 aa)
	cxcl14	Chemokine (C-X-C motif) ligand 14. (99 aa)
	emp2	Epithelial membrane protein 2. (141 aa)
	ENSFHEP00000028442	Ig-like domain-containing protein. (378 aa)
	LOC105937422	Uncharacterized protein. (258 aa)
	ENSFHEP00000004357	Ig-like domain-containing protein. (283 aa)
	lyst	Lysosomal trafficking regulator. (3463 aa)
	ctsh	Uncharacterized protein; Belongs to the peptidase C1 family. (357 aa)
	LOC105924801	Tumor suppressor 2, mitochondrial calcium regulator b. (111 aa)
	LOC105915879	Peptidoglycan-recognition protein; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Involved in innate immunity. (204 aa)
	c9	Complement component 9. (590 aa)
	LOC105921897	Saposin B-type domain-containing protein. (130 aa)
	ENSFHEP00000006749	Uncharacterized protein. (179 aa)
	f2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (620 aa)
	ctsc	Cathepsin C; Belongs to the peptidase C1 family. (463 aa)
	LOC105921896	Saposin B-type domain-containing protein. (145 aa)
	ENSFHEP00000010391	CCAAT enhancer binding protein gamma. (147 aa)
	plekhm2	Pleckstrin homology domain containing, family M (with RUN domain) member 2. (995 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000004357	ENSFHEP00000006749	ENSFHEP00000004357	ENSFHEP00000006749	Ig-like domain-containing protein.	Uncharacterized protein.	0.479
ENSFHEP00000004357	LOC105929155	ENSFHEP00000004357	ENSFHEP00000029391	Ig-like domain-containing protein.	SH2 domain containing 1A duplicate b.	0.520
ENSFHEP00000004357	PRF1	ENSFHEP00000004357	ENSFHEP00000011174	Ig-like domain-containing protein.	Perforin 1.	0.548
ENSFHEP00000004357	RPL30	ENSFHEP00000004357	ENSFHEP00000032905	Ig-like domain-containing protein.	Ribosomal protein L30.	0.428
ENSFHEP00000006749	ENSFHEP00000004357	ENSFHEP00000006749	ENSFHEP00000004357	Uncharacterized protein.	Ig-like domain-containing protein.	0.479
ENSFHEP00000006749	ENSFHEP00000028442	ENSFHEP00000006749	ENSFHEP00000028442	Uncharacterized protein.	Ig-like domain-containing protein.	0.479
ENSFHEP00000006749	LOC105921896	ENSFHEP00000006749	ENSFHEP00000000825	Uncharacterized protein.	Saposin B-type domain-containing protein.	0.807
ENSFHEP00000006749	LOC105921897	ENSFHEP00000006749	ENSFHEP00000000817	Uncharacterized protein.	Saposin B-type domain-containing protein.	0.807
ENSFHEP00000006749	LOC105931538	ENSFHEP00000006749	ENSFHEP00000011548	Uncharacterized protein.	Uncharacterized protein.	0.434
ENSFHEP00000028442	ENSFHEP00000006749	ENSFHEP00000028442	ENSFHEP00000006749	Ig-like domain-containing protein.	Uncharacterized protein.	0.479
ENSFHEP00000028442	LOC105929155	ENSFHEP00000028442	ENSFHEP00000029391	Ig-like domain-containing protein.	SH2 domain containing 1A duplicate b.	0.520
ENSFHEP00000028442	PRF1	ENSFHEP00000028442	ENSFHEP00000011174	Ig-like domain-containing protein.	Perforin 1.	0.548
ENSFHEP00000028442	RPL30	ENSFHEP00000028442	ENSFHEP00000032905	Ig-like domain-containing protein.	Ribosomal protein L30.	0.428
LOC105921896	ENSFHEP00000006749	ENSFHEP00000000825	ENSFHEP00000006749	Saposin B-type domain-containing protein.	Uncharacterized protein.	0.807
LOC105921896	PRF1	ENSFHEP00000000825	ENSFHEP00000011174	Saposin B-type domain-containing protein.	Perforin 1.	0.807
LOC105921896	ctsc	ENSFHEP00000000825	ENSFHEP00000002491	Saposin B-type domain-containing protein.	Cathepsin C; Belongs to the peptidase C1 family.	0.407
LOC105921897	ENSFHEP00000006749	ENSFHEP00000000817	ENSFHEP00000006749	Saposin B-type domain-containing protein.	Uncharacterized protein.	0.807
LOC105921897	PRF1	ENSFHEP00000000817	ENSFHEP00000011174	Saposin B-type domain-containing protein.	Perforin 1.	0.807
LOC105921897	ctsc	ENSFHEP00000000817	ENSFHEP00000002491	Saposin B-type domain-containing protein.	Cathepsin C; Belongs to the peptidase C1 family.	0.407
LOC105929155	ENSFHEP00000004357	ENSFHEP00000029391	ENSFHEP00000004357	SH2 domain containing 1A duplicate b.	Ig-like domain-containing protein.	0.520