(15 nodes) Synaptic transmission, dopaminergic network (Fundulus heteroclitus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	LOC105931336	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
	ENSFHEP00000003389	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (441 aa)
	crhbp	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (320 aa)
	ENSFHEP00000006719	Ubiquitin-like domain-containing protein. (148 aa)
	cdk5	Cyclin-dependent kinase 5-like protein; Belongs to the protein kinase superfamily. (292 aa)
	LOC105936103	D(3) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (412 aa)
	LOC105938824	D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (386 aa)
	LOC105922219	RBR-type E3 ubiquitin transferase. (169 aa)
	crh	Corticotropin releasing hormone b. (171 aa)
	LOC105930175	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (624 aa)
	ENSFHEP00000023313	CRF domain-containing protein. (133 aa)
	drd2	Dopamine receptor D2a; Belongs to the G-protein coupled receptor 1 family. (467 aa)
	ENSFHEP00000025391	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (378 aa)
	slc6a3	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (566 aa)
	ENSFHEP00000031512	G_PROTEIN_RECEP_F1_2 domain-containing protein. (126 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000003389	ENSFHEP00000031512	ENSFHEP00000003389	ENSFHEP00000031512	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.571
ENSFHEP00000003389	LOC105936103	ENSFHEP00000003389	ENSFHEP00000011471	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	D(3) dopamine receptor; Belongs to the G-protein coupled receptor 1 family.	0.545
ENSFHEP00000003389	LOC105938824	ENSFHEP00000003389	ENSFHEP00000014630	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family.	0.545
ENSFHEP00000003389	drd2	ENSFHEP00000003389	ENSFHEP00000024471	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D2a; Belongs to the G-protein coupled receptor 1 family.	0.571
ENSFHEP00000006719	LOC105922219	ENSFHEP00000006719	ENSFHEP00000018097	Ubiquitin-like domain-containing protein.	RBR-type E3 ubiquitin transferase.	0.805
ENSFHEP00000006719	cdk5	ENSFHEP00000006719	ENSFHEP00000010680	Ubiquitin-like domain-containing protein.	Cyclin-dependent kinase 5-like protein; Belongs to the protein kinase superfamily.	0.402
ENSFHEP00000023313	LOC105931336	ENSFHEP00000023313	ENSFHEP00000019451	CRF domain-containing protein.	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.	0.794
ENSFHEP00000023313	crh	ENSFHEP00000023313	ENSFHEP00000022967	CRF domain-containing protein.	Corticotropin releasing hormone b.	0.927
ENSFHEP00000023313	crhbp	ENSFHEP00000023313	ENSFHEP00000004979	CRF domain-containing protein.	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.	0.794
ENSFHEP00000025391	ENSFHEP00000031512	ENSFHEP00000025391	ENSFHEP00000031512	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.589
ENSFHEP00000025391	LOC105936103	ENSFHEP00000025391	ENSFHEP00000011471	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family.	D(3) dopamine receptor; Belongs to the G-protein coupled receptor 1 family.	0.545
ENSFHEP00000025391	LOC105938824	ENSFHEP00000025391	ENSFHEP00000014630	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family.	D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family.	0.545
ENSFHEP00000025391	drd2	ENSFHEP00000025391	ENSFHEP00000024471	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D2a; Belongs to the G-protein coupled receptor 1 family.	0.571
ENSFHEP00000031512	ENSFHEP00000003389	ENSFHEP00000031512	ENSFHEP00000003389	G_PROTEIN_RECEP_F1_2 domain-containing protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.571
ENSFHEP00000031512	ENSFHEP00000025391	ENSFHEP00000031512	ENSFHEP00000025391	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family.	0.589
ENSFHEP00000031512	LOC105930175	ENSFHEP00000031512	ENSFHEP00000023138	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	0.780
ENSFHEP00000031512	LOC105936103	ENSFHEP00000031512	ENSFHEP00000011471	G_PROTEIN_RECEP_F1_2 domain-containing protein.	D(3) dopamine receptor; Belongs to the G-protein coupled receptor 1 family.	0.750
ENSFHEP00000031512	LOC105938824	ENSFHEP00000031512	ENSFHEP00000014630	G_PROTEIN_RECEP_F1_2 domain-containing protein.	D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family.	0.750
ENSFHEP00000031512	slc6a3	ENSFHEP00000031512	ENSFHEP00000025901	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	0.780
LOC105922219	ENSFHEP00000006719	ENSFHEP00000018097	ENSFHEP00000006719	RBR-type E3 ubiquitin transferase.	Ubiquitin-like domain-containing protein.	0.805