(103 nodes) Glial cell differentiation network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	gpr157	G protein-coupled receptor 157. (338 aa)
	LOC105932178	Si:dkey-175m17.7. (862 aa)
	aspa	Aspartoacylase. (318 aa)
	LOC105933860	Uncharacterized protein. (637 aa)
	SOX10	SRY-box transcription factor 10. (504 aa)
	eif2b1	Eukaryotic translation initiation factor 2B, subunit 1 alpha; Belongs to the eIF-2B alpha/beta/delta subunits family. (302 aa)
	LOC105925931	NK2 homeobox 2a. (281 aa)
	LOC105931887	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (434 aa)
	LOC105936190	SRY-box transcription factor 9b. (476 aa)
	mib1	Mindbomb E3 ubiquitin protein ligase 1. (1040 aa)
	LOC105925114	Proteolipid protein 1a. (273 aa)
	gpr17	G protein-coupled receptor 17. (337 aa)
	LOC105918838	Uncharacterized protein. (417 aa)
	mettl14	N6-adenosine-methyltransferase subunit METTL14; Belongs to the MT-A70-like family. (455 aa)
	ppp3r1	Uncharacterized protein. (170 aa)
	LOC105921857	Uncharacterized protein. (230 aa)
	LOC110367130	Adhesion G protein-coupled receptor G4b; Belongs to the G-protein coupled receptor 2 family. (411 aa)
	LOC105917049	Uncharacterized protein. (1411 aa)
	cdk5	Cyclin-dependent kinase 5-like protein; Belongs to the protein kinase superfamily. (292 aa)
	LOC105919986	Meteorin like, glial cell differentiation regulator b. (372 aa)
	dag1	Dystroglycan 1. (869 aa)
	fgf5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)
	ENSFHEP00000012374	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (461 aa)
	ENSFHEP00000012835	EF-hand domain-containing protein. (73 aa)
	LOC105925268	acidPPc domain-containing protein. (343 aa)
	LOC105919313	Uncharacterized protein. (194 aa)
	ENSFHEP00000013958	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (197 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	ENSFHEP00000014679	Uncharacterized protein. (97 aa)
	ENSFHEP00000014699	Uncharacterized protein. (673 aa)
	wasf3	WASP family member 3b. (493 aa)
	mettl3	Methyltransferase like 3; Belongs to the MT-A70-like family. (578 aa)
	LOC105930872	SRY-box transcription factor 9a. (494 aa)
	itgb4	Integrin beta. (1916 aa)
	eif2b5	Eukaryotic translation initiation factor 2B, subunit 5 epsilon. (710 aa)
	adgrg6	Adhesion G protein-coupled receptor G6; Belongs to the G-protein coupled receptor 2 family. (1153 aa)
	eif2b4	Eukaryotic translation initiation factor 2B, subunit 4 delta; Belongs to the eIF-2B alpha/beta/delta subunits family. (548 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (812 aa)
	ENSFHEP00000018697	Paired like homeobox 2Bb. (173 aa)
	ptprz1	Protein tyrosine phosphatase receptor type Z1a. (1330 aa)
	LOC105936474	Vitronectin a. (544 aa)
	LOC105935240	Matrix-remodelling associated 8b. (427 aa)
	LOC105933078	Transforming growth factor beta; Belongs to the TGF-beta family. (381 aa)
	LOC105939281	Vitronectin b. (361 aa)
	fa2h	Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (379 aa)
	LOC105915630	Aspartoacylase (aminocyclase) 3, tandem duplicate 2. (308 aa)
	dusp10	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (472 aa)
	ENSFHEP00000021162	Chondroitin sulfate proteoglycan 5b. (424 aa)
	eif2b2	Eukaryotic translation initiation factor 2B, subunit 2 beta; Belongs to the eIF-2B alpha/beta/delta subunits family. (355 aa)
	metrn	Meteorin, glial cell differentiation regulator. (305 aa)
	LOC105929404	Proteolipid protein 1b. (274 aa)
	ercc2	TFIIH basal transcription factor complex helicase XPD subunit. (795 aa)
	dner	Delta/notch-like EGF repeat containing. (645 aa)
	LOC105926111	Peptidase S72 domain-containing protein. (916 aa)
	ENSFHEP00000022528	Zgc:109889. (278 aa)
	nf1	Neurofibromin 1b. (2547 aa)
	phgdh	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (529 aa)
	nab2	NGFI-A binding protein 2 (EGR1 binding protein 2). (499 aa)
	lef1	Lymphoid enhancer-binding factor 1. (424 aa)
	LOC105930009	Notch receptor 1a. (2479 aa)
	leo1	LEO1 homolog, Paf1/RNA polymerase II complex component. (637 aa)
	ENSFHEP00000026010	ABC transporter domain-containing protein. (201 aa)
	RELN	Reelin. (3373 aa)
	ENSFHEP00000026426	Zgc:109889. (261 aa)
	LOC105917083	SH3 domain and tetratricopeptide repeats 2. (1560 aa)
	LOC105915352	Crumbs cell polarity complex component 2b. (1448 aa)
	CNP	2',3'-cyclic nucleotide 3' phosphodiesterase. (645 aa)
	fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (236 aa)
	prdm8	PR domain zinc finger protein 8. (567 aa)
	ENSFHEP00000028630	Homeobox domain-containing protein. (206 aa)
	LOC105916426	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	LOC105930934	Par-3 family cell polarity regulator alpha, b. (1396 aa)
	LOC105919875	WASP family member 3a. (474 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (905 aa)
	TPPP	Tubulin polymerization promoting protein. (237 aa)
	ENSFHEP00000030788	Dynactin 2 (p50). (282 aa)
	cntn2	Contactin 2. (1035 aa)
	LOC105928048	Tetraspanin. (228 aa)
	LOC105915787	Integrin linked kinase. (452 aa)
	abl1	Tyrosine-protein kinase. (1105 aa)
	PARD3	Par-3 family cell polarity regulator. (1359 aa)
	C1QA	Complement C1q A chain. (257 aa)
	pick1	Protein interacting with prkca 1. (393 aa)
	LOC105935333	Negative regulator of reactive oxygen species. (681 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (246 aa)
	nkx6-2	NK6 homeobox 2. (280 aa)
	LOC105934745	Uncharacterized protein. (449 aa)
	LOC105935885	Tetraspanin. (212 aa)
	eif2b3	Eukaryotic translation initiation factor 2B, subunit 3 gamma. (454 aa)
	sox10	SRY-box transcription factor 10. (452 aa)
	LOC105936791	Uncharacterized protein. (645 aa)
	abl2	Tyrosine-protein kinase. (1188 aa)
	ENSFHEP00000003956	Zinc finger protein 16 like. (392 aa)
	cdkn2c	Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4). (190 aa)
	NCSTN	Nicastrin. (645 aa)
	LOC105919596	Protein tyrosine phosphatase receptor type Z1b. (924 aa)
	LOC105938681	PR domain containing 8. (510 aa)
	egr2	E3 SUMO-protein ligase EGR2. (450 aa)
	crb1	Crumbs cell polarity complex component 1. (1328 aa)
	LOC105934614	Uncharacterized protein. (333 aa)
	ENSFHEP00000000835	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (259 aa)
	ror1	Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (954 aa)
	plpp3	Phospholipid phosphatase 3. (313 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDH2	abl1	ENSFHEP00000030344	ENSFHEP00000032152	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Tyrosine-protein kinase.	0.437
CDH2	abl2	ENSFHEP00000030344	ENSFHEP00000004043	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Tyrosine-protein kinase.	0.437
CNP	LOC105925114	ENSFHEP00000028288	ENSFHEP00000008205	2',3'-cyclic nucleotide 3' phosphodiesterase.	Proteolipid protein 1a.	0.437
CNP	LOC105929404	ENSFHEP00000028288	ENSFHEP00000021932	2',3'-cyclic nucleotide 3' phosphodiesterase.	Proteolipid protein 1b.	0.437
ENSFHEP00000000835	LOC105916426	ENSFHEP00000000835	ENSFHEP00000029057	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.412
ENSFHEP00000000835	LOC105931887	ENSFHEP00000000835	ENSFHEP00000007157	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.412
ENSFHEP00000000835	LOC105933078	ENSFHEP00000000835	ENSFHEP00000019375	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.512
ENSFHEP00000000835	fgf16	ENSFHEP00000000835	ENSFHEP00000028453	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.539
ENSFHEP00000000835	fgf3	ENSFHEP00000000835	ENSFHEP00000033502	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.844
ENSFHEP00000000835	fgf5	ENSFHEP00000000835	ENSFHEP00000011260	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.744
ENSFHEP00000000835	shh	ENSFHEP00000000835	ENSFHEP00000014527	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.617
ENSFHEP00000000835	smo	ENSFHEP00000000835	ENSFHEP00000018258	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.432
ENSFHEP00000000835	sox10	ENSFHEP00000000835	ENSFHEP00000004557	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	SRY-box transcription factor 10.	0.496
ENSFHEP00000012835	LOC105932178	ENSFHEP00000012835	ENSFHEP00000004875	EF-hand domain-containing protein.	Si:dkey-175m17.7.	0.440
ENSFHEP00000012835	dusp10	ENSFHEP00000012835	ENSFHEP00000021005	EF-hand domain-containing protein.	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.440
ENSFHEP00000014679	TPPP	ENSFHEP00000014679	ENSFHEP00000030669	Uncharacterized protein.	Tubulin polymerization promoting protein.	0.512
ENSFHEP00000014699	LOC105930009	ENSFHEP00000014699	ENSFHEP00000025536	Uncharacterized protein.	Notch receptor 1a.	0.403
ENSFHEP00000014699	LOC105933078	ENSFHEP00000014699	ENSFHEP00000019375	Uncharacterized protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.530
ENSFHEP00000014699	NCSTN	ENSFHEP00000014699	ENSFHEP00000003640	Uncharacterized protein.	Nicastrin.	0.533
ENSFHEP00000014699	dner	ENSFHEP00000014699	ENSFHEP00000022163	Uncharacterized protein.	Delta/notch-like EGF repeat containing.	0.467