(83 nodes) Response to ionizing radiation network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SPIDR	Scaffold protein involved in DNA repair. (790 aa)
	ENSFHEP00000034851	TAN domain-containing protein. (173 aa)
	tank	TRAF family member-associated NFKB activator. (338 aa)
	dcun1d3	DCN1-like protein. (327 aa)
	LOC105916751	Uncharacterized protein. (103 aa)
	ptprc	Uncharacterized protein. (989 aa)
	mfsd11	Major facilitator superfamily domain containing 11. (454 aa)
	babam1	BRISC and BRCA1 A complex member 1. (417 aa)
	LOC105927282	ALMS_motif domain-containing protein. (360 aa)
	ENSFHEP00000033293	Uncharacterized protein. (212 aa)
	LOC105934231	Protein kinase domain-containing protein. (674 aa)
	ticrr	Treslin. (1798 aa)
	cop1	COP1 E3 ubiquitin ligase. (695 aa)
	xrcc6	X-ray repair complementing defective repair in Chinese hamster cells 6. (610 aa)
	LOC105940398	Endo/exonuclease/phosphatase domain-containing protein. (328 aa)
	abraxas1	Abraxas 1, BRCA1 A complex subunit. (349 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (416 aa)
	ENSFHEP00000030190	Uncharacterized protein. (81 aa)
	cdca7l	Cell division cycle associated 7b. (394 aa)
	LOC105920547	ETS transcription factor ELK1. (544 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (834 aa)
	brca1	Breast cancer 1, early onset. (1357 aa)
	ENSFHEP00000026441	BRISC and BRCA1 A complex member 2. (267 aa)
	xrcc5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
	LOC105918295	Uncharacterized protein. (424 aa)
	sirt1	Sirtuin 1. (719 aa)
	ENSFHEP00000025154	Uncharacterized protein. (230 aa)
	msh2	MutS homolog 2 (E. coli). (524 aa)
	fancd2	FA complementation group D2. (1376 aa)
	kars1	Lysine--tRNA ligase. (609 aa)
	itgb6	Integrin beta; Belongs to the integrin beta chain family. (1042 aa)
	rad9b	RAD9 checkpoint clamp component B. (400 aa)
	LOC105917232	SAM domain-containing protein. (555 aa)
	topbp1	DNA topoisomerase II binding protein 1. (1256 aa)
	rad1	RAD1 homolog (S. pombe). (279 aa)
	zmpste24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (433 aa)
	LOC105915523	X-ray repair complementing defective repair in Chinese hamster cells 4. (278 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	rnf8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (513 aa)
	men1	Multiple endocrine neoplasia I. (625 aa)
	ENSFHEP00000020833	Uncharacterized protein. (136 aa)
	uimc1	Uncharacterized protein. (942 aa)
	LOC105922837	BRCT domain-containing protein. (146 aa)
	rhno1	Si:ch73-352p4.5. (291 aa)
	rfwd3	Ring finger and WD repeat domain 3. (715 aa)
	LOC105933078	Transforming growth factor beta; Belongs to the TGF-beta family. (381 aa)
	ENSFHEP00000018863	Uncharacterized protein. (153 aa)
	LOC105922182	Uncharacterized protein. (446 aa)
	abcg5	ATP-binding cassette, sub-family G (WHITE), member 5. (654 aa)
	LOC105938240	Endo/exonuclease/phosphatase domain-containing protein. (322 aa)
	smpd1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (630 aa)
	fbxo4	F-box protein 4. (390 aa)
	atr	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2414 aa)
	ercc8	Excision repair cross-complementation group 8. (367 aa)
	tp53bp1	Tumor protein p53 binding protein, 1. (1253 aa)
	ints3	Integrator complex subunit 3. (946 aa)
	bcl2	BCL2 apoptosis regulator b. (230 aa)
	ENSFHEP00000014355	Deoxyribonuclease 1 like 4, tandem duplicate 2. (208 aa)
	ect2	Epithelial cell transforming 2. (888 aa)
	xrra1	X-ray radiation resistance associated 1. (593 aa)
	brca2	BRCA2 DNA repair associated. (2841 aa)
	LOC105932095	Uncharacterized protein. (95 aa)
	ENSFHEP00000009335	Uncharacterized protein. (190 aa)
	XRCC2	X-ray repair cross complementing 2. (235 aa)
	rnf168	Ring finger protein 168. (430 aa)
	rad51	RAD51 recombinase; Belongs to the RecA family. (142 aa)
	ercc1	Excision repair cross-complementation group 1. (366 aa)
	LOC110368010	Ints3 and nabp interacting protein. (69 aa)
	chek2	Checkpoint kinase 2. (458 aa)
	brcc3	BRCA1/BRCA2-containing complex, subunit 3. (239 aa)
	lig4	DNA ligase. (1006 aa)
	nabp1	Nucleic acid binding protein 1a. (219 aa)
	ENSFHEP00000005055	Reverse transcriptase domain-containing protein. (385 aa)
	bax	Uncharacterized protein. (240 aa)
	LOC105917231	Cell division cycle associated 7a. (406 aa)
	LOC105935293	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1439 aa)
	ercc6	Excision repair cross-complementation group 6. (1336 aa)
	LOC105926075	Deoxyribonuclease 1 like 4, tandem duplicate 1. (324 aa)
	LOC105923386	Secreted frizzled-related protein 2 like. (342 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (436 aa)
	brat1	BRCA1-associated ATM activator 1. (859 aa)
	ENSFHEP00000001801	Bloom syndrome, RecQ helicase. (1405 aa)
	eya3	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (622 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000001801	ENSFHEP00000020833	ENSFHEP00000001801	ENSFHEP00000020833	Bloom syndrome, RecQ helicase.	Uncharacterized protein.	0.922
ENSFHEP00000001801	ENSFHEP00000030190	ENSFHEP00000001801	ENSFHEP00000030190	Bloom syndrome, RecQ helicase.	Uncharacterized protein.	0.972
ENSFHEP00000001801	ENSFHEP00000033293	ENSFHEP00000001801	ENSFHEP00000033293	Bloom syndrome, RecQ helicase.	Uncharacterized protein.	0.620
ENSFHEP00000001801	ENSFHEP00000034851	ENSFHEP00000001801	ENSFHEP00000034851	Bloom syndrome, RecQ helicase.	TAN domain-containing protein.	0.922
ENSFHEP00000001801	LOC105917231	ENSFHEP00000001801	ENSFHEP00000004242	Bloom syndrome, RecQ helicase.	Cell division cycle associated 7a.	0.717
ENSFHEP00000001801	LOC105922837	ENSFHEP00000001801	ENSFHEP00000020152	Bloom syndrome, RecQ helicase.	BRCT domain-containing protein.	0.843
ENSFHEP00000001801	SPIDR	ENSFHEP00000001801	ENSFHEP00000011358	Bloom syndrome, RecQ helicase.	Scaffold protein involved in DNA repair.	0.704
ENSFHEP00000001801	XRCC2	ENSFHEP00000001801	ENSFHEP00000009215	Bloom syndrome, RecQ helicase.	X-ray repair cross complementing 2.	0.791
ENSFHEP00000001801	atr	ENSFHEP00000001801	ENSFHEP00000015732	Bloom syndrome, RecQ helicase.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.983
ENSFHEP00000001801	brca1	ENSFHEP00000001801	ENSFHEP00000026695	Bloom syndrome, RecQ helicase.	Breast cancer 1, early onset.	0.926
ENSFHEP00000001801	brca2	ENSFHEP00000001801	ENSFHEP00000010259	Bloom syndrome, RecQ helicase.	BRCA2 DNA repair associated.	0.867
ENSFHEP00000001801	cdca7l	ENSFHEP00000001801	ENSFHEP00000028953	Bloom syndrome, RecQ helicase.	Cell division cycle associated 7b.	0.717
ENSFHEP00000001801	chek2	ENSFHEP00000001801	ENSFHEP00000006857	Bloom syndrome, RecQ helicase.	Checkpoint kinase 2.	0.809
ENSFHEP00000001801	ercc1	ENSFHEP00000001801	ENSFHEP00000007331	Bloom syndrome, RecQ helicase.	Excision repair cross-complementation group 1.	0.681
ENSFHEP00000001801	ercc6	ENSFHEP00000001801	ENSFHEP00000003932	Bloom syndrome, RecQ helicase.	Excision repair cross-complementation group 6.	0.516
ENSFHEP00000001801	fancd2	ENSFHEP00000001801	ENSFHEP00000024652	Bloom syndrome, RecQ helicase.	FA complementation group D2.	0.796
ENSFHEP00000001801	lig4	ENSFHEP00000001801	ENSFHEP00000006360	Bloom syndrome, RecQ helicase.	DNA ligase.	0.630
ENSFHEP00000001801	msh2	ENSFHEP00000001801	ENSFHEP00000024689	Bloom syndrome, RecQ helicase.	MutS homolog 2 (E. coli).	0.846
ENSFHEP00000001801	rad1	ENSFHEP00000001801	ENSFHEP00000023436	Bloom syndrome, RecQ helicase.	RAD1 homolog (S. pombe).	0.879
ENSFHEP00000001801	rad51	ENSFHEP00000001801	ENSFHEP00000007370	Bloom syndrome, RecQ helicase.	RAD51 recombinase; Belongs to the RecA family.	0.972