(23 nodes) Response to gamma radiation network (Fundulus heteroclitus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	dcun1d3	DCN1-like protein. (327 aa)
	ercc6	Excision repair cross-complementation group 6. (1336 aa)
	bax	Uncharacterized protein. (240 aa)
	lig4	DNA ligase. (1006 aa)
	chek2	Checkpoint kinase 2. (458 aa)
	XRCC2	X-ray repair cross complementing 2. (235 aa)
	ENSFHEP00000009335	Uncharacterized protein. (190 aa)
	brca2	BRCA2 DNA repair associated. (2841 aa)
	bcl2	BCL2 apoptosis regulator b. (230 aa)
	atr	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2414 aa)
	ENSFHEP00000018863	Uncharacterized protein. (153 aa)
	ENSFHEP00000020833	Uncharacterized protein. (136 aa)
	men1	Multiple endocrine neoplasia I. (625 aa)
	ENSFHEP00000034851	TAN domain-containing protein. (173 aa)
	zmpste24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (433 aa)
	LOC105917232	SAM domain-containing protein. (555 aa)
	fancd2	FA complementation group D2. (1376 aa)
	xrcc5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (834 aa)
	LOC105920547	ETS transcription factor ELK1. (544 aa)
	xrcc6	X-ray repair complementing defective repair in Chinese hamster cells 6. (610 aa)
	LOC105934231	Protein kinase domain-containing protein. (674 aa)
	ptprc	Uncharacterized protein. (989 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000009335	ENSFHEP00000018863	ENSFHEP00000009335	ENSFHEP00000018863	Uncharacterized protein.	Uncharacterized protein.	0.941
ENSFHEP00000009335	bax	ENSFHEP00000009335	ENSFHEP00000004805	Uncharacterized protein.	Uncharacterized protein.	0.996
ENSFHEP00000009335	xrcc6	ENSFHEP00000009335	ENSFHEP00000031142	Uncharacterized protein.	X-ray repair complementing defective repair in Chinese hamster cells 6.	0.431
ENSFHEP00000018863	ENSFHEP00000009335	ENSFHEP00000018863	ENSFHEP00000009335	Uncharacterized protein.	Uncharacterized protein.	0.941
ENSFHEP00000018863	bax	ENSFHEP00000018863	ENSFHEP00000004805	Uncharacterized protein.	Uncharacterized protein.	0.972
ENSFHEP00000018863	bcl2	ENSFHEP00000018863	ENSFHEP00000014796	Uncharacterized protein.	BCL2 apoptosis regulator b.	0.941
ENSFHEP00000020833	ENSFHEP00000034851	ENSFHEP00000020833	ENSFHEP00000034851	Uncharacterized protein.	TAN domain-containing protein.	0.923
ENSFHEP00000020833	XRCC2	ENSFHEP00000020833	ENSFHEP00000009215	Uncharacterized protein.	X-ray repair cross complementing 2.	0.712
ENSFHEP00000020833	atr	ENSFHEP00000020833	ENSFHEP00000015732	Uncharacterized protein.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.991
ENSFHEP00000020833	brca2	ENSFHEP00000020833	ENSFHEP00000010259	Uncharacterized protein.	BRCA2 DNA repair associated.	0.862
ENSFHEP00000020833	chek2	ENSFHEP00000020833	ENSFHEP00000006857	Uncharacterized protein.	Checkpoint kinase 2.	0.970
ENSFHEP00000020833	fancd2	ENSFHEP00000020833	ENSFHEP00000024652	Uncharacterized protein.	FA complementation group D2.	0.631
ENSFHEP00000020833	lig4	ENSFHEP00000020833	ENSFHEP00000006360	Uncharacterized protein.	DNA ligase.	0.636
ENSFHEP00000020833	xrcc5	ENSFHEP00000020833	ENSFHEP00000025953	Uncharacterized protein.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.913
ENSFHEP00000020833	xrcc6	ENSFHEP00000020833	ENSFHEP00000031142	Uncharacterized protein.	X-ray repair complementing defective repair in Chinese hamster cells 6.	0.924
ENSFHEP00000034851	ENSFHEP00000020833	ENSFHEP00000034851	ENSFHEP00000020833	TAN domain-containing protein.	Uncharacterized protein.	0.923
ENSFHEP00000034851	XRCC2	ENSFHEP00000034851	ENSFHEP00000009215	TAN domain-containing protein.	X-ray repair cross complementing 2.	0.712
ENSFHEP00000034851	atr	ENSFHEP00000034851	ENSFHEP00000015732	TAN domain-containing protein.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.991
ENSFHEP00000034851	brca2	ENSFHEP00000034851	ENSFHEP00000010259	TAN domain-containing protein.	BRCA2 DNA repair associated.	0.862
ENSFHEP00000034851	chek2	ENSFHEP00000034851	ENSFHEP00000006857	TAN domain-containing protein.	Checkpoint kinase 2.	0.970