(62 nodes) Epithelial cell migration network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	sema3d	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D; Belongs to the semaphorin family. (721 aa)
	slc24a5	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (481 aa)
	LOC105939768	Protein kinase N1a. (739 aa)
	emp2	Epithelial membrane protein 2. (141 aa)
	ppard	Peroxisome proliferator-activated receptor delta b. (508 aa)
	ccbe1	Collagen and calcium binding EGF domains 1. (397 aa)
	LOC105932251	GIPC PDZ domain containing family, member 2. (329 aa)
	LOC105924010	Uncharacterized protein. (323 aa)
	s100z	Protein S100; Belongs to the S-100 family. (98 aa)
	LOC105923947	Uncharacterized protein. (353 aa)
	LOC105937193	Si:dkey-174i8.1. (523 aa)
	LOXL4	Lysyl oxidase like 4. (894 aa)
	CYP1C1	Cytochrome P450, family 1, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (529 aa)
	LOC105918804	Si:dkeyp-75h12.2. (685 aa)
	ENSFHEP00000009896	WD repeat-containing and planar cell polarity effector protein fritz. (447 aa)
	LOC105933301	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (718 aa)
	psenen	Presenilin enhancer, gamma-secretase subunit. (101 aa)
	ENSFHEP00000010757	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (447 aa)
	ARSB	Arylsulfatase B. (515 aa)
	LOC105928180	CC chemokine SCYA116. (106 aa)
	LOC105930939	Sulfatase domain-containing protein. (739 aa)
	srf	Serum response factor b. (599 aa)
	ENSFHEP00000013800	Gremlin 1a, DAN family BMP antagonist. (181 aa)
	ENSFHEP00000014528	Uncharacterized protein. (309 aa)
	scarb1	Scavenger receptor class B, member 1; Belongs to the CD36 family. (495 aa)
	ENSFHEP00000015557	Uncharacterized protein. (588 aa)
	LOC105918528	Ephrin-B2a; Belongs to the ephrin family. (335 aa)
	LOC105929718	Anillin domain-containing protein. (962 aa)
	LOC105930748	LRRCT domain-containing protein. (335 aa)
	ENSFHEP00000019258	Uncharacterized protein. (255 aa)
	rab13	RAB13, member RAS oncogene family. (200 aa)
	LOC105926177	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (546 aa)
	ENSFHEP00000021441	EMI domain-containing protein. (722 aa)
	ENSFHEP00000022179	Lysyl oxidase-like 4. (349 aa)
	PTP4A3	Protein tyrosine phosphatase type IVA 3. (170 aa)
	LOC105916734	Testis associated actin remodelling kinase 2. (632 aa)
	LOC105916722	Leukotriene B4 receptor 2b. (348 aa)
	LOC105925576	Arylsulfatase family, member J. (560 aa)
	LOC105933906	Endothelin 2. (161 aa)
	LOC105925825	Protein kinase N3. (915 aa)
	LOC105920139	Arylsulfatase family, member Ia. (572 aa)
	ENSFHEP00000026175	Cytochrome P450, family 1, subfamily C, polypeptide 2; Belongs to the cytochrome P450 family. (524 aa)
	vegfa	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
	lmo2	LIM domain only 2 (rhombotin-like 1). (156 aa)
	LOC105929964	Protein kinase N1b. (961 aa)
	LOC105928303	Protein tyrosine phosphatase non-receptor type 9b. (755 aa)
	LOC105917690	Leukotriene B4 receptor 2a. (368 aa)
	ENSFHEP00000027612	Uncharacterized protein. (86 aa)
	LOC105930472	Uncharacterized protein. (327 aa)
	GREM1	Gremlin 1, DAN family BMP antagonist. (153 aa)
	gipc1	GIPC PDZ domain containing family, member 1. (331 aa)
	LOC105917537	Thrombospondin, type I, domain containing 7Aa. (1602 aa)
	lgals8	Galectin. (314 aa)
	apoa4	Apolipoprotein A-Ib. (290 aa)
	ptpn9	Protein tyrosine phosphatase non-receptor type 9a. (570 aa)
	gipc3	GIPC PDZ domain containing family, member 3. (331 aa)
	anln	Anillin, actin binding protein. (1211 aa)
	ENSFHEP00000032510	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (133 aa)
	nrp1	Neuropilin; Belongs to the neuropilin family. (924 aa)
	LOC105928706	Uncharacterized protein. (158 aa)
	ENSFHEP00000033600	Galectin. (121 aa)
	ENSFHEP00000033603	Galectin. (289 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000014528	s100z	ENSFHEP00000014528	ENSFHEP00000004982	Uncharacterized protein.	Protein S100; Belongs to the S-100 family.	0.407
ENSFHEP00000015557	LOC105929964	ENSFHEP00000015557	ENSFHEP00000026677	Uncharacterized protein.	Protein kinase N1b.	0.901
ENSFHEP00000015557	anln	ENSFHEP00000015557	ENSFHEP00000032317	Uncharacterized protein.	Anillin, actin binding protein.	0.427
ENSFHEP00000021441	LOC105933301	ENSFHEP00000021441	ENSFHEP00000010202	EMI domain-containing protein.	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	0.450
LOC105916722	LOC105917690	ENSFHEP00000023595	ENSFHEP00000027260	Leukotriene B4 receptor 2b.	Leukotriene B4 receptor 2a.	0.758
LOC105917690	LOC105916722	ENSFHEP00000027260	ENSFHEP00000023595	Leukotriene B4 receptor 2a.	Leukotriene B4 receptor 2b.	0.758
LOC105924010	lmo2	ENSFHEP00000004618	ENSFHEP00000026291	Uncharacterized protein.	LIM domain only 2 (rhombotin-like 1).	0.501
LOC105924010	srf	ENSFHEP00000004618	ENSFHEP00000013718	Uncharacterized protein.	Serum response factor b.	0.933
LOC105929964	ENSFHEP00000015557	ENSFHEP00000026677	ENSFHEP00000015557	Protein kinase N1b.	Uncharacterized protein.	0.901
LOC105929964	LOC105939768	ENSFHEP00000026677	ENSFHEP00000002045	Protein kinase N1b.	Protein kinase N1a.	0.901
LOC105929964	anln	ENSFHEP00000026677	ENSFHEP00000032317	Protein kinase N1b.	Anillin, actin binding protein.	0.427
LOC105932251	nrp1	ENSFHEP00000004168	ENSFHEP00000032633	GIPC PDZ domain containing family, member 2.	Neuropilin; Belongs to the neuropilin family.	0.461
LOC105933301	ENSFHEP00000021441	ENSFHEP00000010202	ENSFHEP00000021441	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	EMI domain-containing protein.	0.450
LOC105933301	lmo2	ENSFHEP00000010202	ENSFHEP00000026291	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	LIM domain only 2 (rhombotin-like 1).	0.414
LOC105933301	nrp1	ENSFHEP00000010202	ENSFHEP00000032633	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	Neuropilin; Belongs to the neuropilin family.	0.420
LOC105933301	vegfa	ENSFHEP00000010202	ENSFHEP00000026266	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family.	0.620
LOC105939768	LOC105929964	ENSFHEP00000002045	ENSFHEP00000026677	Protein kinase N1a.	Protein kinase N1b.	0.901
LOC105939768	anln	ENSFHEP00000002045	ENSFHEP00000032317	Protein kinase N1a.	Anillin, actin binding protein.	0.427
anln	ENSFHEP00000015557	ENSFHEP00000032317	ENSFHEP00000015557	Anillin, actin binding protein.	Uncharacterized protein.	0.427
anln	LOC105929964	ENSFHEP00000032317	ENSFHEP00000026677	Anillin, actin binding protein.	Protein kinase N1b.	0.427