STRINGSTRING
TGFBR2 TGFBR2 LOC105915406 LOC105915406 ENSFHEP00000009959 ENSFHEP00000009959 LOC105920824 LOC105920824 LOC105939523 LOC105939523 LOC105919389 LOC105919389 ENSFHEP00000010447 ENSFHEP00000010447 mtor mtor itgb1bp1 itgb1bp1 ARSB ARSB LOC105915958 LOC105915958 atp5f1b atp5f1b LOC105930397 LOC105930397 LOC105925268 LOC105925268 LOC105930939 LOC105930939 ENSFHEP00000013026 ENSFHEP00000013026 LOC105918680 LOC105918680 LOC105920438 LOC105920438 glipr2 glipr2 ENSFHEP00000014758 ENSFHEP00000014758 capn7 capn7 APOH APOH srpx2 srpx2 VASH1 VASH1 LOC105928007 LOC105928007 vash2 vash2 tbxa2r tbxa2r aamp aamp ATP5F1A ATP5F1A LOC105929622 LOC105929622 mst1r mst1r LOC105931910 LOC105931910 LOC105920313 LOC105920313 LOC105933677 LOC105933677 LOC105928516 LOC105928516 LOC105931924 LOC105931924 LOC105933078 LOC105933078 agt agt bsg bsg ENSFHEP00000019886 ENSFHEP00000019886 LOC105926607 LOC105926607 plcg1 plcg1 dusp10 dusp10 bcas3 bcas3 ENSFHEP00000021441 ENSFHEP00000021441 LOC105917287 LOC105917287 LOC105932394 LOC105932394 nf1 nf1 LOC105918963 LOC105918963 LOC105935688 LOC105935688 lgmn lgmn ENSFHEP00000023942 ENSFHEP00000023942 LOC105925576 LOC105925576 ptpn23 ptpn23 LOC105933547 LOC105933547 LOC105932869 LOC105932869 LOC105927641 LOC105927641 LOC105920139 LOC105920139 atp5f1a atp5f1a sirt1 sirt1 bmpr2 bmpr2 angpt2 angpt2 LOC105935090 LOC105935090 vegfa vegfa ENSFHEP00000026670 ENSFHEP00000026670 met met LOC105918211 LOC105918211 fgf16 fgf16 LOC105915295 LOC105915295 LOC105937876 LOC105937876 LOC105933233 LOC105933233 LOC105915942 LOC105915942 LOC105923864 LOC105923864 APOH-2 APOH-2 fgf2 fgf2 LOC105919250 LOC105919250 LOC105928008 LOC105928008 LOC105929083 LOC105929083 nrp1 nrp1 LOC105930794 LOC105930794 ENSFHEP00000033024 ENSFHEP00000033024 epcam epcam fgf4 fgf4 gpi gpi LOC105939305 LOC105939305 LOC105921477 LOC105921477 LOC105928914 LOC105928914 plpp3 plpp3 sash1 sash1 zc3h12a zc3h12a LOC105921986 LOC105921986 LOC105940274 LOC105940274 LOC105939829 LOC105939829 rgcc rgcc ctsh ctsh fgf7 fgf7 LOC105939793 LOC105939793 map2k5 map2k5 LOC105915540 LOC105915540 LOC105926891 LOC105926891 emp2 emp2 LOC105934479 LOC105934479 ENSFHEP00000004332 ENSFHEP00000004332 LOC105926046 LOC105926046 LOC105916686 LOC105916686 LOC105919545 LOC105919545 LOC105932178 LOC105932178 RIN2 RIN2 LOC105932867 LOC105932867 LOC105937193 LOC105937193 GATA2 GATA2 nfe2l2 nfe2l2 tsta3 tsta3 pik3cg pik3cg LOC105928246 LOC105928246 LOC105920078 LOC105920078 plcg2 plcg2 meox2 meox2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (540 aa)
LOC105915406Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (561 aa)
ENSFHEP00000009959Uncharacterized protein. (664 aa)
LOC105920824Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
LOC105939523Apolipoprotein Eb. (284 aa)
LOC105919389Ras and Rab interactor 2. (1048 aa)
ENSFHEP00000010447Ephrin-A1a; Belongs to the ephrin family. (220 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2495 aa)
itgb1bp1Integrin beta-1-binding protein 1. (288 aa)
ARSBArylsulfatase B. (515 aa)
LOC105915958Uncharacterized protein. (1351 aa)
atp5f1bATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (520 aa)
LOC105930397RAB25, member RAS oncogene family a. (234 aa)
LOC105925268acidPPc domain-containing protein. (343 aa)
LOC105930939Sulfatase domain-containing protein. (739 aa)
ENSFHEP00000013026JunE proto-oncogene, AP-1 transcription factor subunit. (334 aa)
LOC105918680ADAM metallopeptidase domain 17b. (476 aa)
LOC105920438Transforming growth factor beta; Belongs to the TGF-beta family. (418 aa)
glipr2GLI pathogenesis-related 2, like; Belongs to the CRISP family. (156 aa)
ENSFHEP00000014758Uncharacterized protein. (112 aa)
capn7Calpain 7; Belongs to the peptidase C2 family. (813 aa)
APOHBeta-2-glycoprotein 1. (363 aa)
srpx2Sushi-repeat containing protein X-linked 2. (384 aa)
VASH1Vasohibin-1. (332 aa)
LOC105928007Heat shock protein, alpha-crystallin-related, 1; Belongs to the small heat shock protein (HSP20) family. (202 aa)
vash2Vasohibin 2. (367 aa)
tbxa2rThromboxane A2 receptor. (375 aa)
aampAngio-associated, migratory cell protein. (418 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (551 aa)
LOC105929622Glucose-6-phosphate isomerase; Belongs to the GPI family. (533 aa)
mst1rMacrophage-stimulating protein receptor. (1375 aa)
LOC105931910Fibroblast growth factor binding protein 1b. (202 aa)
LOC105920313Protein tyrosine kinase 2 beta, b; Belongs to the protein kinase superfamily. Tyr protein kinase family. (996 aa)
LOC105933677Macrophage stimulating 1 receptor a. (1409 aa)
LOC105928516Ephrin-A1b; Belongs to the ephrin family. (231 aa)
LOC105931924Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
LOC105933078Transforming growth factor beta; Belongs to the TGF-beta family. (381 aa)
agtAngiotensinogen; Belongs to the serpin family. (503 aa)
bsgBasigin. (273 aa)
ENSFHEP00000019886Uncharacterized protein. (184 aa)
LOC105926607SH3 domain-binding protein 1. (729 aa)
plcg11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1309 aa)
dusp10Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (472 aa)
bcas3BCAS3 microtubule associated cell migration factor. (949 aa)
ENSFHEP00000021441EMI domain-containing protein. (722 aa)
LOC105917287Junction plakoglobin a. (722 aa)
LOC105932394SAM and SH3 domain containing 1b. (1093 aa)
nf1Neurofibromin 1b. (2547 aa)
LOC105918963Protein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa)
LOC105935688Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (182 aa)
lgmnLegumain. (436 aa)
ENSFHEP00000023942CARD domain-containing protein. (171 aa)
LOC105925576Arylsulfatase family, member J. (560 aa)
ptpn23Protein tyrosine phosphatase, non-receptor type 23, a. (1543 aa)
LOC105933547Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (523 aa)
LOC1059328691-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1309 aa)
LOC105927641ADAM metallopeptidase domain 17a. (865 aa)
LOC105920139Arylsulfatase family, member Ia. (572 aa)
atp5f1aATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (551 aa)
sirt1Sirtuin 1. (719 aa)
bmpr2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1050 aa)
angpt2Angiopoietin 2a. (491 aa)
LOC105935090Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1098 aa)
vegfaVascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
ENSFHEP00000026670Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (127 aa)
metMET proto-oncogene, receptor tyrosine kinase. (1372 aa)
LOC105918211Insulin-like growth factor 2b. (215 aa)
fgf16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (236 aa)
LOC105915295Heat shock protein, alpha-crystallin-related, b15; Belongs to the small heat shock protein (HSP20) family. (203 aa)
LOC105937876Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC105933233Carbonic anhydrase XVI b. (1385 aa)
LOC105915942Glutamine synthetase. (373 aa)
LOC105923864Apolipoprotein Ea. (262 aa)
APOH-2Uncharacterized protein. (348 aa)
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
LOC105919250MBD domain-containing protein. (881 aa)
LOC105928008Heat shock protein, alpha-crystallin-related, 1; Belongs to the small heat shock protein (HSP20) family. (202 aa)
LOC105929083ADP-ribosylation factor 6b; Belongs to the small GTPase superfamily. Arf family. (184 aa)
nrp1Neuropilin; Belongs to the neuropilin family. (924 aa)
LOC105930794Bone morphogenetic protein 10, like. (458 aa)
ENSFHEP00000033024Uncharacterized protein. (61 aa)
epcamEpithelial cell adhesion molecule. (349 aa)
fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
gpiGlucose-6-phosphate isomerase; Belongs to the GPI family. (657 aa)
LOC105939305Usher syndrome 1C binding protein 1. (702 aa)
LOC105921477Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (948 aa)
LOC105928914Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (324 aa)
plpp3Phospholipid phosphatase 3. (313 aa)
sash1SAM and SH3 domain containing 1a. (1224 aa)
zc3h12aZinc finger CCCH-type containing 12A. (618 aa)
LOC105921986Si:dkey-206d17.12. (588 aa)
LOC105940274Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (673 aa)
LOC105939829Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
rgccRegulator of cell cycle. (127 aa)
ctshUncharacterized protein; Belongs to the peptidase C1 family. (357 aa)
fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (199 aa)
LOC105939793RAB25, member RAS oncogene family b. (207 aa)
map2k5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (444 aa)
LOC105915540Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (732 aa)
LOC105926891CD40 molecule, TNF receptor superfamily member 5. (308 aa)
emp2Epithelial membrane protein 2. (141 aa)
LOC105934479Angiopoietin 2b. (505 aa)
ENSFHEP00000004332Guanylate kinase-like domain-containing protein. (244 aa)
LOC105926046Endothelial transcription factor GATA-2. (462 aa)
LOC105916686Glutamine synthetase. (371 aa)
LOC105919545Reversion-inducing-cysteine-rich protein with kazal motifs. (646 aa)
LOC105932178Si:dkey-175m17.7. (862 aa)
RIN2Ras and Rab interactor 2. (976 aa)
LOC105932867Si:ch211-191a24.4. (294 aa)
LOC105937193Si:dkey-174i8.1. (523 aa)
GATA2Endothelial transcription factor GATA-2. (460 aa)
nfe2l2Nuclear factor, erythroid 2-like 2a. (621 aa)
tsta3Tissue specific transplantation antigen P35B. (323 aa)
pik3cgPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1122 aa)
LOC105928246Heparin-binding EGF-like growth factor a. (222 aa)
LOC105920078Angiopoietin 4. (528 aa)
plcg21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1224 aa)
meox2Homeobox protein MOX-2. (312 aa)
Your Current Organism:
Fundulus heteroclitus
NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog
Server load: low (20%) [HD]