(22 nodes) Negative regulation of protein processing network (Fundulus heteroclitus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSFHEP00000015248	Uncharacterized protein. (235 aa)
	bcl2l12	Vacuolar-sorting protein SNF8. (334 aa)
	cast	Calpastatin. (892 aa)
	serpine1	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (390 aa)
	serpine2	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; Belongs to the serpin family. (449 aa)
	LOC105931906	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (301 aa)
	ENSFHEP00000033314	ANK_REP_REGION domain-containing protein. (762 aa)
	chac1	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (249 aa)
	LOC105923080	Uncharacterized protein. (321 aa)
	LOC105938372	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (199 aa)
	LOC105920618	SERPIN domain-containing protein; Belongs to the serpin family. (548 aa)
	glg1	Golgi glycoprotein 1b. (994 aa)
	ENSFHEP00000018558	Protein kinase domain-containing protein. (516 aa)
	ENSFHEP00000017921	Growth arrest-specific 1b. (243 aa)
	LOC105930314	Interleukin 1 receptor type 2. (409 aa)
	tmem98	Transmembrane protein 98. (224 aa)
	LOC105923651	Cystatin domain-containing protein. (138 aa)
	ENSFHEP00000009221	Uncharacterized protein. (268 aa)
	ctsz	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (303 aa)
	LOC105932234	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (271 aa)
	ENSFHEP00000003609	Growth arrest-specific 1a. (259 aa)
	LOC105934538	SERPIN domain-containing protein; Belongs to the serpin family. (477 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000003609	ENSFHEP00000009221	ENSFHEP00000003609	ENSFHEP00000009221	Growth arrest-specific 1a.	Uncharacterized protein.	0.950
ENSFHEP00000003609	ENSFHEP00000017921	ENSFHEP00000003609	ENSFHEP00000017921	Growth arrest-specific 1a.	Growth arrest-specific 1b.	0.908
ENSFHEP00000009221	ENSFHEP00000003609	ENSFHEP00000009221	ENSFHEP00000003609	Uncharacterized protein.	Growth arrest-specific 1a.	0.950
ENSFHEP00000009221	ENSFHEP00000017921	ENSFHEP00000009221	ENSFHEP00000017921	Uncharacterized protein.	Growth arrest-specific 1b.	0.905
ENSFHEP00000015248	LOC105923080	ENSFHEP00000015248	ENSFHEP00000029868	Uncharacterized protein.	Uncharacterized protein.	0.909
ENSFHEP00000015248	glg1	ENSFHEP00000015248	ENSFHEP00000026602	Uncharacterized protein.	Golgi glycoprotein 1b.	0.907
ENSFHEP00000017921	ENSFHEP00000003609	ENSFHEP00000017921	ENSFHEP00000003609	Growth arrest-specific 1b.	Growth arrest-specific 1a.	0.908
ENSFHEP00000017921	ENSFHEP00000009221	ENSFHEP00000017921	ENSFHEP00000009221	Growth arrest-specific 1b.	Uncharacterized protein.	0.905
ENSFHEP00000018558	ENSFHEP00000033314	ENSFHEP00000018558	ENSFHEP00000033314	Protein kinase domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.942
ENSFHEP00000033314	ENSFHEP00000018558	ENSFHEP00000033314	ENSFHEP00000018558	ANK_REP_REGION domain-containing protein.	Protein kinase domain-containing protein.	0.942
LOC105923080	ENSFHEP00000015248	ENSFHEP00000029868	ENSFHEP00000015248	Uncharacterized protein.	Uncharacterized protein.	0.909
LOC105923080	glg1	ENSFHEP00000029868	ENSFHEP00000026602	Uncharacterized protein.	Golgi glycoprotein 1b.	0.905
LOC105938372	chac1	ENSFHEP00000029206	ENSFHEP00000033285	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	0.953
chac1	LOC105938372	ENSFHEP00000033285	ENSFHEP00000029206	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	0.953
glg1	ENSFHEP00000015248	ENSFHEP00000026602	ENSFHEP00000015248	Golgi glycoprotein 1b.	Uncharacterized protein.	0.907
glg1	LOC105923080	ENSFHEP00000026602	ENSFHEP00000029868	Golgi glycoprotein 1b.	Uncharacterized protein.	0.905
serpine1	serpine2	ENSFHEP00000034886	ENSFHEP00000033803	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family.	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; Belongs to the serpin family.	0.685
serpine2	serpine1	ENSFHEP00000033803	ENSFHEP00000034886	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; Belongs to the serpin family.	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family.	0.685