(52 nodes) PML body network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSFHEP00000001303	Uncharacterized protein. (1401 aa)
	top3a	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1037 aa)
	rb1	Retinoblastoma-associated protein. (913 aa)
	ENSFHEP00000001801	Bloom syndrome, RecQ helicase. (1405 aa)
	LOC105932971	Structural maintenance of chromosomes 6. (1086 aa)
	nsmce2	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (230 aa)
	CIITA	Class II major histocompatibility complex transactivator. (930 aa)
	LOC105924123	RING-type domain-containing protein. (834 aa)
	usp7	Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1227 aa)
	chfr	Checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase. (643 aa)
	chek2	Checkpoint kinase 2. (458 aa)
	rad51	RAD51 recombinase; Belongs to the RecA family. (142 aa)
	mlip	Uncharacterized protein. (859 aa)
	gcna	Germ cell nuclear acidic peptidase. (706 aa)
	sqstm1	Sequestosome 1. (450 aa)
	LOC105916077	Nedd4 binding protein 1. (687 aa)
	ankrd1	Ankyrin repeat domain 1a (cardiac muscle). (314 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2495 aa)
	atrx	ATRX chromatin remodeler. (1852 aa)
	ENSFHEP00000011538	Uncharacterized protein. (405 aa)
	RPA1	Uncharacterized protein. (253 aa)
	LOC105916434	Endo/exonuclease/phosphatase domain-containing protein. (287 aa)
	ski	V-ski avian sarcoma viral oncogene homolog a. (726 aa)
	atr	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2414 aa)
	ppargc1a	Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (1270 aa)
	sumo1	Small ubiquitin-related modifier. (101 aa)
	ENSFHEP00000016114	Uncharacterized protein. (163 aa)
	LOC105918082	PAT1 homolog 1, processing body mRNA decay factor. (800 aa)
	ENSFHEP00000016131	Uncharacterized protein. (133 aa)
	LOC105926274	Thymine DNA glycosylase, tandem duplicate 2. (386 aa)
	tdg	Thymine DNA glycosylase, tandem duplicate 1. (459 aa)
	rfwd3	Ring finger and WD repeat domain 3. (715 aa)
	LOC105939875	Topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase. (754 aa)
	tp53inp2	Uncharacterized protein. (291 aa)
	ENSFHEP00000021233	Nuclear factor, erythroid 2. (440 aa)
	smc6	Si:dkey-119f1.1. (1042 aa)
	ENSFHEP00000022489	Morc6_S5 domain-containing protein. (306 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (604 aa)
	klhl20	Kelch-like family member 20. (554 aa)
	LOC105938715	RING-type domain-containing protein. (602 aa)
	smc5	Structural maintenance of chromosomes 5. (1072 aa)
	topbp1	DNA topoisomerase II binding protein 1. (1256 aa)
	sirt1	Sirtuin 1. (719 aa)
	LOC105916085	PAT1 homolog 2. (495 aa)
	casp8ap2	Uncharacterized protein. (1760 aa)
	rnf4	RING-type domain-containing protein. (185 aa)
	daxx	Death-domain associated protein. (737 aa)
	LOC105930441	Tyrosyl-DNA phosphodiesterase 2b. (325 aa)
	rnf111	Ring finger protein 111. (992 aa)
	tp53inp1	Tumor protein p53 inducible nuclear protein 1. (286 aa)
	ENSFHEP00000030190	Uncharacterized protein. (81 aa)
	rpain	RPA interacting protein. (223 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000001303	ENSFHEP00000001801	ENSFHEP00000001303	ENSFHEP00000001801	Uncharacterized protein.	Bloom syndrome, RecQ helicase.	0.455
ENSFHEP00000001303	ENSFHEP00000030190	ENSFHEP00000001303	ENSFHEP00000030190	Uncharacterized protein.	Uncharacterized protein.	0.763
ENSFHEP00000001303	RPA1	ENSFHEP00000001303	ENSFHEP00000011881	Uncharacterized protein.	Uncharacterized protein.	0.415
ENSFHEP00000001303	chek2	ENSFHEP00000001303	ENSFHEP00000006857	Uncharacterized protein.	Checkpoint kinase 2.	0.404
ENSFHEP00000001303	daxx	ENSFHEP00000001303	ENSFHEP00000027381	Uncharacterized protein.	Death-domain associated protein.	0.987
ENSFHEP00000001303	rad51	ENSFHEP00000001303	ENSFHEP00000007370	Uncharacterized protein.	RAD51 recombinase; Belongs to the RecA family.	0.763
ENSFHEP00000001303	rpa1	ENSFHEP00000001303	ENSFHEP00000022905	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.415
ENSFHEP00000001303	smc5	ENSFHEP00000001303	ENSFHEP00000023550	Uncharacterized protein.	Structural maintenance of chromosomes 5.	0.616
ENSFHEP00000001303	sumo1	ENSFHEP00000001303	ENSFHEP00000015878	Uncharacterized protein.	Small ubiquitin-related modifier.	0.495
ENSFHEP00000001801	ENSFHEP00000001303	ENSFHEP00000001801	ENSFHEP00000001303	Bloom syndrome, RecQ helicase.	Uncharacterized protein.	0.455
ENSFHEP00000001801	ENSFHEP00000030190	ENSFHEP00000001801	ENSFHEP00000030190	Bloom syndrome, RecQ helicase.	Uncharacterized protein.	0.972
ENSFHEP00000001801	LOC105932971	ENSFHEP00000001801	ENSFHEP00000002381	Bloom syndrome, RecQ helicase.	Structural maintenance of chromosomes 6.	0.750
ENSFHEP00000001801	RPA1	ENSFHEP00000001801	ENSFHEP00000011881	Bloom syndrome, RecQ helicase.	Uncharacterized protein.	0.996
ENSFHEP00000001801	atr	ENSFHEP00000001801	ENSFHEP00000015732	Bloom syndrome, RecQ helicase.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.983
ENSFHEP00000001801	atrx	ENSFHEP00000001801	ENSFHEP00000011035	Bloom syndrome, RecQ helicase.	ATRX chromatin remodeler.	0.455
ENSFHEP00000001801	chek2	ENSFHEP00000001801	ENSFHEP00000006857	Bloom syndrome, RecQ helicase.	Checkpoint kinase 2.	0.809
ENSFHEP00000001801	mtor	ENSFHEP00000001801	ENSFHEP00000010587	Bloom syndrome, RecQ helicase.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.400
ENSFHEP00000001801	nsmce2	ENSFHEP00000001801	ENSFHEP00000003190	Bloom syndrome, RecQ helicase.	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase.	0.717
ENSFHEP00000001801	rad51	ENSFHEP00000001801	ENSFHEP00000007370	Bloom syndrome, RecQ helicase.	RAD51 recombinase; Belongs to the RecA family.	0.972
ENSFHEP00000001801	rnf4	ENSFHEP00000001801	ENSFHEP00000027055	Bloom syndrome, RecQ helicase.	RING-type domain-containing protein.	0.415