(14 nodes) Hydroxymethyl-, formyl- and related transferase activity network (Fundulus heteroclitus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	LOC105939809	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (217 aa)
	atic	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (628 aa)
	LOC105916057	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (483 aa)
	ENSFHEP00000013747	Aldedh domain-containing protein. (163 aa)
	ENSFHEP00000015728	SHMT domain-containing protein. (48 aa)
	amt	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (417 aa)
	shmt1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (512 aa)
	ENSFHEP00000021849	SHMT domain-containing protein. (169 aa)
	gcsh	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (174 aa)
	LOC105916055	SHMT domain-containing protein. (483 aa)
	ENSFHEP00000030739	SHMT domain-containing protein. (88 aa)
	LOC105933714	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (902 aa)
	gart	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1014 aa)
	aldh1l2	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (847 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000013747	ENSFHEP00000015728	ENSFHEP00000013747	ENSFHEP00000015728	Aldedh domain-containing protein.	SHMT domain-containing protein.	0.905
ENSFHEP00000013747	ENSFHEP00000021849	ENSFHEP00000013747	ENSFHEP00000021849	Aldedh domain-containing protein.	SHMT domain-containing protein.	0.912
ENSFHEP00000013747	ENSFHEP00000030739	ENSFHEP00000013747	ENSFHEP00000030739	Aldedh domain-containing protein.	SHMT domain-containing protein.	0.905
ENSFHEP00000013747	LOC105916055	ENSFHEP00000013747	ENSFHEP00000027456	Aldedh domain-containing protein.	SHMT domain-containing protein.	0.901
ENSFHEP00000013747	LOC105916057	ENSFHEP00000013747	ENSFHEP00000009641	Aldedh domain-containing protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.901
ENSFHEP00000013747	LOC105933714	ENSFHEP00000013747	ENSFHEP00000032018	Aldedh domain-containing protein.	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	0.898
ENSFHEP00000013747	LOC105939809	ENSFHEP00000013747	ENSFHEP00000001675	Aldedh domain-containing protein.	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	0.472
ENSFHEP00000013747	aldh1l2	ENSFHEP00000013747	ENSFHEP00000013765	Aldedh domain-containing protein.	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	0.935
ENSFHEP00000013747	amt	ENSFHEP00000013747	ENSFHEP00000016897	Aldedh domain-containing protein.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	0.933
ENSFHEP00000013747	gart	ENSFHEP00000013747	ENSFHEP00000032372	Aldedh domain-containing protein.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.964
ENSFHEP00000013747	gcsh	ENSFHEP00000013747	ENSFHEP00000024512	Aldedh domain-containing protein.	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	0.472
ENSFHEP00000013747	shmt1	ENSFHEP00000013747	ENSFHEP00000019297	Aldedh domain-containing protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.901
ENSFHEP00000015728	ENSFHEP00000013747	ENSFHEP00000015728	ENSFHEP00000013747	SHMT domain-containing protein.	Aldedh domain-containing protein.	0.905
ENSFHEP00000015728	LOC105933714	ENSFHEP00000015728	ENSFHEP00000032018	SHMT domain-containing protein.	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	0.913
ENSFHEP00000015728	LOC105939809	ENSFHEP00000015728	ENSFHEP00000001675	SHMT domain-containing protein.	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	0.958
ENSFHEP00000015728	aldh1l2	ENSFHEP00000015728	ENSFHEP00000013765	SHMT domain-containing protein.	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	0.905
ENSFHEP00000015728	amt	ENSFHEP00000015728	ENSFHEP00000016897	SHMT domain-containing protein.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	0.968
ENSFHEP00000015728	atic	ENSFHEP00000015728	ENSFHEP00000008667	SHMT domain-containing protein.	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.	0.986
ENSFHEP00000015728	gart	ENSFHEP00000015728	ENSFHEP00000032372	SHMT domain-containing protein.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.998
ENSFHEP00000015728	gcsh	ENSFHEP00000015728	ENSFHEP00000024512	SHMT domain-containing protein.	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	0.843