(69 nodes) Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides network (Fundulus heteroclitus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	LOC105934614	Uncharacterized protein. (333 aa)
	sirt6	Sirtuin 6. (352 aa)
	ENSFHEP00000002668	Histidine triad nucleotide binding protein 3. (159 aa)
	upb1	Ureidopropionase, beta. (399 aa)
	LOC105933535	Si:ch211-256m1.8. (1578 aa)
	LOC105935657	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa)
	aspa	Aspartoacylase. (318 aa)
	ENSFHEP00000006249	Uncharacterized protein. (70 aa)
	pigl	Phosphatidylinositol glycan anchor biosynthesis, class L. (270 aa)
	aga	Aspartylglucosaminidase. (338 aa)
	LOC105935570	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (430 aa)
	ENSFHEP00000007760	Coiled-coil domain-containing protein 96. (496 aa)
	pdf	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins; Belongs to the polypeptide deformylase family. (267 aa)
	hdac5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1134 aa)
	LOC105929974	Peptidoglycan recognition protein 6. (472 aa)
	hdac7	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1043 aa)
	faah2	Fatty acid amide hydrolase 2b. (487 aa)
	nit2	Nitrilase family, member 2. (286 aa)
	LOC105924246	Biotinidase. (513 aa)
	LOC105924216	Biotinidase. (505 aa)
	sirt2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (382 aa)
	LOC105926306	Histone deacetylase 9b. (559 aa)
	sirt4	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (307 aa)
	LOC105928563	Glutaminase 2a (liver, mitochondrial). (605 aa)
	LOC105915879	Peptidoglycan-recognition protein; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Involved in innate immunity. (204 aa)
	LOC105940401	Glutaminase 2b (liver, mitochondrial). (462 aa)
	sirt3	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (344 aa)
	LOC105935397	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	ENSFHEP00000015952	Histone deacetylase 6. (462 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (490 aa)
	hdac10	Histone deacetylase 10. (683 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1101 aa)
	sirt7	Sirtuin 7. (408 aa)
	asrgl1	Asparaginase like 1. (309 aa)
	ngly1	N-glycanase 1. (704 aa)
	acy1	Aminoacylase 1. (225 aa)
	LOC105920964	Glutaminase a. (563 aa)
	asah2	Neutral ceramidase. (745 aa)
	hdac8	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (401 aa)
	NAAA	N-acylethanolamine acid amidase; Belongs to the acid ceramidase family. (355 aa)
	LOC105934206	Uncharacterized protein; Belongs to the acid ceramidase family. (350 aa)
	acer2	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (295 aa)
	nit1	Nitrilase 1. (317 aa)
	acer1	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (266 aa)
	acer3	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (268 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
	amdhd2	N-acetylglucosamine-6-phosphate deacetylase; Belongs to the metallo-dependent hydrolases superfamily. NagA family. (408 aa)
	LOC105915630	Aspartoacylase (aminocyclase) 3, tandem duplicate 2. (308 aa)
	ENSFHEP00000020957	Fatty acid amide hydrolase. (499 aa)
	hint3	HIT domain-containing protein. (159 aa)
	pglyrp2	Uncharacterized protein. (482 aa)
	ENSFHEP00000022727	Amidase domain-containing protein. (257 aa)
	pm20d1	Peptidase M20 domain containing 1, tandem duplicate 2. (520 aa)
	sirt5	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (325 aa)
	LOC105931735	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (936 aa)
	LOC105925946	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
	sirt1	Sirtuin 1. (719 aa)
	LOC105923354	Si:dkey-103j14.5. (165 aa)
	asah1	N-acylsphingosine amidohydrolase (acid ceramidase) 1a; Belongs to the acid ceramidase family. (392 aa)
	LOC105916521	ANK_REP_REGION domain-containing protein. (482 aa)
	ENSFHEP00000027779	Histone deacetylase 12. (237 aa)
	hdac11	Histone deacetylase 11. (357 aa)
	nadsyn1	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (707 aa)
	LOC105935246	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (304 aa)
	NTAN1	N-terminal asparagine amidase. (307 aa)
	aspg	Asparaginase homolog (S. cerevisiae). (801 aa)
	ENSFHEP00000031354	Nt_Gln_amidase domain-containing protein. (82 aa)
	afmid	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (312 aa)
	wdyhv1	WDYHV motif containing 1. (191 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000006249	amdhd2	ENSFHEP00000006249	ENSFHEP00000020499	Uncharacterized protein.	N-acetylglucosamine-6-phosphate deacetylase; Belongs to the metallo-dependent hydrolases superfamily. NagA family.	0.950
ENSFHEP00000007760	HDAC2	ENSFHEP00000007760	ENSFHEP00000016430	Coiled-coil domain-containing protein 96.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.524
ENSFHEP00000007760	HDAC3	ENSFHEP00000007760	ENSFHEP00000020300	Coiled-coil domain-containing protein 96.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.524
ENSFHEP00000007760	LOC105925946	ENSFHEP00000007760	ENSFHEP00000025309	Coiled-coil domain-containing protein 96.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.524
ENSFHEP00000007760	LOC105935397	ENSFHEP00000007760	ENSFHEP00000015563	Coiled-coil domain-containing protein 96.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.524
ENSFHEP00000007760	hdac8	ENSFHEP00000007760	ENSFHEP00000017701	Coiled-coil domain-containing protein 96.	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.524
ENSFHEP00000007760	sirt4	ENSFHEP00000007760	ENSFHEP00000013384	Coiled-coil domain-containing protein 96.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.436
ENSFHEP00000015952	ENSFHEP00000027779	ENSFHEP00000015952	ENSFHEP00000027779	Histone deacetylase 6.	Histone deacetylase 12.	0.569
ENSFHEP00000015952	HDAC2	ENSFHEP00000015952	ENSFHEP00000016430	Histone deacetylase 6.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.619
ENSFHEP00000015952	HDAC3	ENSFHEP00000015952	ENSFHEP00000020300	Histone deacetylase 6.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.624
ENSFHEP00000015952	LOC105925946	ENSFHEP00000015952	ENSFHEP00000025309	Histone deacetylase 6.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.620
ENSFHEP00000015952	LOC105926306	ENSFHEP00000015952	ENSFHEP00000013238	Histone deacetylase 6.	Histone deacetylase 9b.	0.720
ENSFHEP00000015952	LOC105935397	ENSFHEP00000015952	ENSFHEP00000015563	Histone deacetylase 6.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.620
ENSFHEP00000015952	hdac11	ENSFHEP00000015952	ENSFHEP00000028149	Histone deacetylase 6.	Histone deacetylase 11.	0.545
ENSFHEP00000015952	hdac8	ENSFHEP00000015952	ENSFHEP00000017701	Histone deacetylase 6.	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.616
ENSFHEP00000015952	sirt1	ENSFHEP00000015952	ENSFHEP00000025372	Histone deacetylase 6.	Sirtuin 1.	0.560
ENSFHEP00000015952	sirt4	ENSFHEP00000015952	ENSFHEP00000013384	Histone deacetylase 6.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.436
ENSFHEP00000015952	sirt6	ENSFHEP00000015952	ENSFHEP00000001386	Histone deacetylase 6.	Sirtuin 6.	0.401
ENSFHEP00000020957	LOC105916521	ENSFHEP00000020957	ENSFHEP00000027228	Fatty acid amide hydrolase.	ANK_REP_REGION domain-containing protein.	0.567
ENSFHEP00000020957	LOC105920964	ENSFHEP00000020957	ENSFHEP00000017442	Fatty acid amide hydrolase.	Glutaminase a.	0.567