(19 nodes) Neuronal action potential network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105933218	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (306 aa)
	p2rx7	Purinergic receptor P2X, ligand-gated ion channel, 7. (615 aa)
	GJD2	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (280 aa)
	LOC105930265	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1856 aa)
	LOC105925167	Potassium large conductance calcium-activated channel, subfamily M, beta member 2. (236 aa)
	p2rx3	Uncharacterized protein. (328 aa)
	ENSFHEP00000027816	Uncharacterized protein. (162 aa)
	ENSFHEP00000021593	Uncharacterized protein. (398 aa)
	ENSFHEP00000020873	Uncharacterized protein. (95 aa)
	ENSFHEP00000017402	Uncharacterized protein. (283 aa)
	LOC105925071	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (462 aa)
	LOC105937035	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1971 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2495 aa)
	LOC105935461	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2000 aa)
	ENSFHEP00000010216	Uncharacterized protein. (49 aa)
	ENSFHEP00000010149	Ion_trans domain-containing protein. (204 aa)
	LOC105920712	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (418 aa)
	LOC105931748	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1763 aa)
	LOC105929329	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (309 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000010149	ENSFHEP00000017402	ENSFHEP00000010149	ENSFHEP00000017402	Ion_trans domain-containing protein.	Uncharacterized protein.	0.940
ENSFHEP00000010149	ENSFHEP00000021593	ENSFHEP00000010149	ENSFHEP00000021593	Ion_trans domain-containing protein.	Uncharacterized protein.	0.899
ENSFHEP00000010149	LOC105925071	ENSFHEP00000010149	ENSFHEP00000013834	Ion_trans domain-containing protein.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.899
ENSFHEP00000010216	LOC105920712	ENSFHEP00000010216	ENSFHEP00000006925	Uncharacterized protein.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.816
ENSFHEP00000010216	p2rx7	ENSFHEP00000010216	ENSFHEP00000034153	Uncharacterized protein.	Purinergic receptor P2X, ligand-gated ion channel, 7.	0.758
ENSFHEP00000017402	ENSFHEP00000010149	ENSFHEP00000017402	ENSFHEP00000010149	Uncharacterized protein.	Ion_trans domain-containing protein.	0.940
ENSFHEP00000017402	ENSFHEP00000021593	ENSFHEP00000017402	ENSFHEP00000021593	Uncharacterized protein.	Uncharacterized protein.	0.954
ENSFHEP00000017402	LOC105925071	ENSFHEP00000017402	ENSFHEP00000013834	Uncharacterized protein.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.758
ENSFHEP00000021593	ENSFHEP00000010149	ENSFHEP00000021593	ENSFHEP00000010149	Uncharacterized protein.	Ion_trans domain-containing protein.	0.899
ENSFHEP00000021593	ENSFHEP00000017402	ENSFHEP00000021593	ENSFHEP00000017402	Uncharacterized protein.	Uncharacterized protein.	0.954
ENSFHEP00000021593	LOC105925071	ENSFHEP00000021593	ENSFHEP00000013834	Uncharacterized protein.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.947
ENSFHEP00000027816	LOC105920712	ENSFHEP00000027816	ENSFHEP00000006925	Uncharacterized protein.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.816
ENSFHEP00000027816	p2rx7	ENSFHEP00000027816	ENSFHEP00000034153	Uncharacterized protein.	Purinergic receptor P2X, ligand-gated ion channel, 7.	0.758
GJD2	LOC105929329	ENSFHEP00000033070	ENSFHEP00000000748	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.935
GJD2	LOC105933218	ENSFHEP00000033070	ENSFHEP00000016112	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.969
LOC105920712	ENSFHEP00000010216	ENSFHEP00000006925	ENSFHEP00000010216	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	Uncharacterized protein.	0.816
LOC105920712	ENSFHEP00000027816	ENSFHEP00000006925	ENSFHEP00000027816	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	Uncharacterized protein.	0.816
LOC105920712	p2rx3	ENSFHEP00000006925	ENSFHEP00000027888	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	Uncharacterized protein.	0.831
LOC105920712	p2rx7	ENSFHEP00000006925	ENSFHEP00000034153	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	Purinergic receptor P2X, ligand-gated ion channel, 7.	0.909
LOC105925071	ENSFHEP00000010149	ENSFHEP00000013834	ENSFHEP00000010149	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Ion_trans domain-containing protein.	0.899