(27 nodes) Intracellular steroid hormone receptor signaling pathway network (Fundulus heteroclitus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	SRC	Tyrosine-protein kinase. (548 aa)
	LOC105935507	Estrogen receptor 2b. (673 aa)
	LOC105929919	ATP-dependent RNA helicase DDX17, putative; Belongs to the DEAD box helicase family. (497 aa)
	DDX5	DEAD-box helicase 5; Belongs to the DEAD box helicase family. (632 aa)
	LOC105936121	Uncharacterized protein. (991 aa)
	LOC105926616	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (387 aa)
	nkx3-1	NK3 homeobox 1. (187 aa)
	trip4	Thyroid hormone receptor interactor 4. (574 aa)
	ppargc1b	Peroxisome proliferator-activated receptor gamma, coactivator 1 beta. (927 aa)
	phb	Prohibitin. (271 aa)
	LOC105922518	Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (498 aa)
	LOC105920641	Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor). (765 aa)
	daxx	Death-domain associated protein. (737 aa)
	LOC105925373	Ubiquitin protein ligase E3A. (823 aa)
	rwdd1	RWD domain containing 1. (224 aa)
	tmf1	TATA element modulatory factor 1. (1150 aa)
	NR3C1	Nuclear receptor subfamily 3 group C member 1. (772 aa)
	AR	Androgen receptor. (752 aa)
	LOC105931285	Androgen receptor. (683 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (620 aa)
	pgr	Progesterone receptor. (670 aa)
	UBE3A	Ubiquitin protein ligase E3A. (912 aa)
	ubr5	Ubiquitin protein ligase E3 component n-recognin 5. (2535 aa)
	LOC105935418	Estrogen receptor 2a. (553 aa)
	LOC105931443	Uncharacterized protein; Belongs to the DEAD box helicase family. (625 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1792 aa)
	LOC105918234	Tyrosine-protein kinase. (550 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	LOC105918234	ENSFHEP00000022152	ENSFHEP00000012505	Androgen receptor.	Tyrosine-protein kinase.	0.645
AR	LOC105920641	ENSFHEP00000022152	ENSFHEP00000027740	Androgen receptor.	Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor).	0.604
AR	LOC105931285	ENSFHEP00000022152	ENSFHEP00000021977	Androgen receptor.	Androgen receptor.	0.948
AR	NR3C1	ENSFHEP00000022152	ENSFHEP00000023649	Androgen receptor.	Nuclear receptor subfamily 3 group C member 1.	0.604
AR	SRC	ENSFHEP00000022152	ENSFHEP00000011333	Androgen receptor.	Tyrosine-protein kinase.	0.645
AR	UBE3A	ENSFHEP00000022152	ENSFHEP00000018143	Androgen receptor.	Ubiquitin protein ligase E3A.	0.464
AR	daxx	ENSFHEP00000022152	ENSFHEP00000027381	Androgen receptor.	Death-domain associated protein.	0.519
AR	esr1	ENSFHEP00000022152	ENSFHEP00000021278	Androgen receptor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.617
AR	med1	ENSFHEP00000022152	ENSFHEP00000014059	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.689
AR	nkx3-1	ENSFHEP00000022152	ENSFHEP00000032519	Androgen receptor.	NK3 homeobox 1.	0.564
AR	pgr	ENSFHEP00000022152	ENSFHEP00000019500	Androgen receptor.	Progesterone receptor.	0.654
DDX5	LOC105929919	ENSFHEP00000004623	ENSFHEP00000009792	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	ATP-dependent RNA helicase DDX17, putative; Belongs to the DEAD box helicase family.	0.899
DDX5	LOC105935418	ENSFHEP00000004623	ENSFHEP00000014291	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Estrogen receptor 2a.	0.692
DDX5	LOC105935507	ENSFHEP00000004623	ENSFHEP00000010364	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Estrogen receptor 2b.	0.692
DDX5	esr1	ENSFHEP00000004623	ENSFHEP00000021278	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.692
LOC105918234	AR	ENSFHEP00000012505	ENSFHEP00000022152	Tyrosine-protein kinase.	Androgen receptor.	0.645
LOC105918234	LOC105931285	ENSFHEP00000012505	ENSFHEP00000021977	Tyrosine-protein kinase.	Androgen receptor.	0.485
LOC105918234	LOC105935418	ENSFHEP00000012505	ENSFHEP00000014291	Tyrosine-protein kinase.	Estrogen receptor 2a.	0.628
LOC105918234	LOC105935507	ENSFHEP00000012505	ENSFHEP00000010364	Tyrosine-protein kinase.	Estrogen receptor 2b.	0.628
LOC105918234	SRC	ENSFHEP00000012505	ENSFHEP00000011333	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.947