(117 nodes) Intracellular receptor signaling pathway network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSFHEP00000020133	Nuclear receptor subfamily 2, group F, member 6b. (333 aa)
	ALPK1	Alpha kinase 1. (1088 aa)
	NR2E3	Nuclear receptor subfamily 2 group E member 3. (418 aa)
	LOC105937331	Nuclear receptor subfamily 5, group A, member 5. (537 aa)
	LOC105929447	Uncharacterized protein. (456 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (620 aa)
	nr2e1	Nuclear receptor subfamily 2, group E, member 1. (379 aa)
	LOC105928996	Nuclear receptor subfamily 1, group D, member 4a. (579 aa)
	ENSFHEP00000021136	Si:ch211-15b10.6. (195 aa)
	PPARG	Peroxisome proliferator activated receptor gamma. (533 aa)
	LOC105927864	Retinoic acid receptor RXR-beta. (471 aa)
	nr1h3	Nuclear receptor subfamily 1, group H, member 3. (464 aa)
	ubr5	Ubiquitin protein ligase E3 component n-recognin 5. (2535 aa)
	LOC105939401	Estrogen-related receptor gamma a. (544 aa)
	nr1d2	Nuclear receptor subfamily 1, group D, member 2b. (598 aa)
	rarb	Retinoic acid receptor beta variant 1. (462 aa)
	LOC105928447	RAR-related orphan receptor C. (472 aa)
	nr5a2	Nuclear receptor subfamily 5, group A, member 2. (523 aa)
	ESRRB	Estrogen-related receptor beta. (480 aa)
	ahrr	Aryl hydrocarbon receptor repressor. (680 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (576 aa)
	LOC105936496	Nuclear receptor related 1. (561 aa)
	LOC105940391	Thyroid hormone receptor alpha. (413 aa)
	sting1	Stimulator of interferon genes protein. (400 aa)
	LOC105935418	Estrogen receptor 2a. (553 aa)
	hnf4a	Hepatocyte nuclear factor 4, alpha. (454 aa)
	LOC105931443	Uncharacterized protein; Belongs to the DEAD box helicase family. (625 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1792 aa)
	LOC105926355	Retinoic acid receptor RXR-beta. (444 aa)
	LOC105918234	Tyrosine-protein kinase. (550 aa)
	LOC105940013	Uncharacterized protein. (413 aa)
	LOC105915319	Ring finger protein 34b. (405 aa)
	LOC105917026	Uncharacterized protein. (811 aa)
	SRC	Tyrosine-protein kinase. (548 aa)
	LOC105937897	Uncharacterized protein. (448 aa)
	dhx58	DEXH (Asp-Glu-X-His) box polypeptide 58. (681 aa)
	RXRB	Retinoid X receptor beta. (361 aa)
	LOC105935507	Estrogen receptor 2b. (673 aa)
	LOC105929919	ATP-dependent RNA helicase DDX17, putative; Belongs to the DEAD box helicase family. (497 aa)
	fam120b	Family with sequence similarity 120B. (734 aa)
	LOC105935556	Uncharacterized protein. (445 aa)
	LOC105925883	Vitamin D receptor a. (420 aa)
	LOC105936755	Nuclear receptor subfamily 1, group D, member 2a. (577 aa)
	LOC105939110	Nuclear receptor subfamily 1, group D, member 4b. (644 aa)
	ppara	Peroxisome proliferator-activated receptor alpha a. (490 aa)
	LOC105917115	Uncharacterized protein. (460 aa)
	nr1h4	Nuclear receptor subfamily 1, group H, member 4. (489 aa)
	nr2f1	Nuclear receptor subfamily 2, group F, member 1a. (411 aa)
	NR4A1	Nuclear receptor subfamily 4 group A member 1. (590 aa)
	LOC105935242	Nuclear receptor subfamily 4, group A, member 1. (569 aa)
	LOC105937232	Uncharacterized protein. (946 aa)
	LOC105933893	Nuclear receptor subfamily 2, group F, member 6a. (406 aa)
	DDX5	DEAD-box helicase 5; Belongs to the DEAD box helicase family. (632 aa)
	snw1	SNW domain containing 1. (544 aa)
	LOC105924070	Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. (441 aa)
	LOC105930636	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (354 aa)
	inava	Innate immunity activator a. (570 aa)
	ppard	Peroxisome proliferator-activated receptor delta b. (508 aa)
	LOC105927263	Hepatocyte nuclear factor 4, gamma. (481 aa)
	nr2c2	Nuclear receptor subfamily 2, group C, member 2. (558 aa)
	CLPB	ClpB homolog, mitochondrial AAA ATPase chaperonin. (390 aa)
	LOC105938548	Peroxisome proliferator-activated receptor alpha b. (469 aa)
	ENSFHEP00000001323	Uncharacterized protein. (67 aa)
	rora	RAR-related orphan receptor A, paralog a. (470 aa)
	LOC105927870	RAR-related orphan receptor C a. (472 aa)
	nfkbia	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (314 aa)
	lacc1	Laccase (multicopper oxidoreductase) domain containing 1. (407 aa)
	LOC105934149	COUP transcription factor 2. (440 aa)
	RARG	Retinoic acid receptor beta variant 1. (511 aa)
	LOC105928804	Ring finger protein 34a. (380 aa)
	LOC105934568	RAR-related orphan receptor C b. (482 aa)
	LOC105931285	Androgen receptor. (683 aa)
	AR	Androgen receptor. (752 aa)
	ptf1a	Pancreas transcription factor 1 subunit alpha. (267 aa)
	rorb	RAR-related orphan receptor B. (479 aa)
	LOC105933949	Nuclear receptor subfamily 2, group F, member 2. (418 aa)
	NR3C1	Nuclear receptor subfamily 3 group C member 1. (772 aa)
	LOC105916695	Nuclear receptor subfamily 2, group E, member 3. (413 aa)
	tmf1	TATA element modulatory factor 1. (1150 aa)
	LOC105937229	BHLH domain-containing protein. (949 aa)
	esrra	Uncharacterized protein. (433 aa)
	LOC105935622	Retinoic acid receptor beta variant 1. (455 aa)
	LOC105931721	Vitamin D receptor b. (425 aa)
	nr2c1	Nuclear receptor subfamily 2, group C, member 1. (610 aa)
	LOC105939116	Innate immunity activator b. (577 aa)
	LOC105918865	Uncharacterized protein. (530 aa)
	rwdd1	RWD domain containing 1. (224 aa)
	pitx2	Homeobox protein. (312 aa)
	LOC105939073	Retinoic acid receptor, gamma b. (375 aa)
	LOC105925290	Uncharacterized protein. (468 aa)
	LOC105936121	Uncharacterized protein. (991 aa)
	LOC105925373	Ubiquitin protein ligase E3A. (823 aa)
	daxx	Death-domain associated protein. (737 aa)
	LOC105920641	Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor). (765 aa)
	LOC105925854	Nuclear receptor subfamily 1, group H, member 5. (494 aa)
	LOC105917025	Aryl hydrocarbon receptor 2b. (913 aa)
	LOC105922518	Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (498 aa)
	phb	Prohibitin. (271 aa)
	LOC105936061	Nuclear receptor subfamily 2, group F, member 5. (404 aa)
	ppargc1b	Peroxisome proliferator-activated receptor gamma, coactivator 1 beta. (927 aa)
	nr4a3	Nuclear receptor subfamily 4, group A, member 3. (681 aa)
	rxra	Retinoid X receptor, alpha a. (501 aa)
	trip4	Thyroid hormone receptor interactor 4. (574 aa)
	nr1i2	Uncharacterized protein. (439 aa)
	thrb	Thyroid hormone receptor beta. (395 aa)
	nkx3-1	NK3 homeobox 1. (187 aa)
	LOC105929715	LSM14A mRNA processing body assembly factor a. (486 aa)
	nr1d1	Nuclear receptor subfamily 1, group d, member 1. (613 aa)
	nr4a2	Nuclear receptor subfamily 4, group A, member 2b. (601 aa)
	LOC105927825	Nuclear receptor subfamily 5, group A, member 1a. (456 aa)
	LOC105919714	LSM14A mRNA processing body assembly factor b. (440 aa)
	ifih1	Interferon induced with helicase C domain 1. (973 aa)
	LOC105925539	Si:ch211-15b10.6. (187 aa)
	LOC105926616	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (387 aa)
	pgr	Progesterone receptor. (670 aa)
	nr6a1	Nuclear receptor subfamily 6, group A, member 1a. (492 aa)
	UBE3A	Ubiquitin protein ligase E3A. (912 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALPK1	ENSFHEP00000021136	ENSFHEP00000020524	ENSFHEP00000021136	Alpha kinase 1.	Si:ch211-15b10.6.	0.824
ALPK1	LOC105925539	ENSFHEP00000020524	ENSFHEP00000035073	Alpha kinase 1.	Si:ch211-15b10.6.	0.824
AR	LOC105918234	ENSFHEP00000022152	ENSFHEP00000012505	Androgen receptor.	Tyrosine-protein kinase.	0.645
AR	LOC105920641	ENSFHEP00000022152	ENSFHEP00000027740	Androgen receptor.	Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor).	0.604
AR	LOC105931285	ENSFHEP00000022152	ENSFHEP00000021977	Androgen receptor.	Androgen receptor.	0.948
AR	NR3C1	ENSFHEP00000022152	ENSFHEP00000023649	Androgen receptor.	Nuclear receptor subfamily 3 group C member 1.	0.604
AR	SRC	ENSFHEP00000022152	ENSFHEP00000011333	Androgen receptor.	Tyrosine-protein kinase.	0.645
AR	UBE3A	ENSFHEP00000022152	ENSFHEP00000018143	Androgen receptor.	Ubiquitin protein ligase E3A.	0.464
AR	daxx	ENSFHEP00000022152	ENSFHEP00000027381	Androgen receptor.	Death-domain associated protein.	0.519
AR	esr1	ENSFHEP00000022152	ENSFHEP00000021278	Androgen receptor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.617
AR	med1	ENSFHEP00000022152	ENSFHEP00000014059	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.689
AR	nkx3-1	ENSFHEP00000022152	ENSFHEP00000032519	Androgen receptor.	NK3 homeobox 1.	0.564
AR	pgr	ENSFHEP00000022152	ENSFHEP00000019500	Androgen receptor.	Progesterone receptor.	0.654
CLPB	phb	ENSFHEP00000002138	ENSFHEP00000028873	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Prohibitin.	0.512
DDX5	LOC105919714	ENSFHEP00000004623	ENSFHEP00000034266	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	LSM14A mRNA processing body assembly factor b.	0.453
DDX5	LOC105929715	ENSFHEP00000004623	ENSFHEP00000032801	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	LSM14A mRNA processing body assembly factor a.	0.453
DDX5	LOC105929919	ENSFHEP00000004623	ENSFHEP00000009792	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	ATP-dependent RNA helicase DDX17, putative; Belongs to the DEAD box helicase family.	0.899
DDX5	LOC105935418	ENSFHEP00000004623	ENSFHEP00000014291	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Estrogen receptor 2a.	0.692
DDX5	LOC105935507	ENSFHEP00000004623	ENSFHEP00000010364	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Estrogen receptor 2b.	0.692
DDX5	esr1	ENSFHEP00000004623	ENSFHEP00000021278	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.692