(40 nodes) Cortical actin cytoskeleton organization network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fmnl3	Formin-like 3. (1007 aa)
	ENSFHEP00000000538	4_1_CTD domain-containing protein. (155 aa)
	plek	Pleckstrin. (373 aa)
	ENSFHEP00000002118	Uncharacterized protein. (52 aa)
	epb41l3	Erythrocyte membrane protein band 4.1-like 3b. (858 aa)
	LOC105931872	Uncharacterized protein. (627 aa)
	LLGL1	LLGL scribble cell polarity complex component 1. (1064 aa)
	strip1	Striatin interacting protein 1. (816 aa)
	ENSFHEP00000004576	Uncharacterized protein. (304 aa)
	fmnl2	Formin-like 2a. (1085 aa)
	pdcd6ip	Programmed cell death 6 interacting protein. (880 aa)
	ENSFHEP00000010398	Formin_GBD_N domain-containing protein. (70 aa)
	ENSFHEP00000010407	GBD/FH3 domain-containing protein. (104 aa)
	ENSFHEP00000010423	Formin homology 2 domain containing 1. (628 aa)
	cdk5	Cyclin-dependent kinase 5-like protein; Belongs to the protein kinase superfamily. (292 aa)
	nckap1	NCK-associated protein 1. (1180 aa)
	LOC105933773	Si:dkey-178k16.1. (835 aa)
	ENSFHEP00000014758	Uncharacterized protein. (112 aa)
	LOC105929718	Anillin domain-containing protein. (962 aa)
	LOC105937617	Erythrocyte membrane protein band 4.1 like 2. (1029 aa)
	rab13	RAB13, member RAS oncogene family. (200 aa)
	ENSFHEP00000019655	Uncharacterized protein; Belongs to the protein kinase superfamily. (385 aa)
	ENSFHEP00000019697	Rho_Binding domain-containing protein. (183 aa)
	ENSFHEP00000019719	Phorbol-ester/DAG-type domain-containing protein. (139 aa)
	LOC105937579	Angiomotin like 2b. (692 aa)
	LOC105916758	Formin homology 2 domain containing 3a. (1613 aa)
	akap11	A kinase (PRKA) anchor protein 11. (1889 aa)
	ROCK1	Rho associated coiled-coil containing protein kinase 1. (521 aa)
	LOC105937495	Formin-like 1a. (1129 aa)
	racgap1	Rac GTPase-activating protein 1. (630 aa)
	ENSFHEP00000025150	FERM domain-containing protein. (404 aa)
	ENSFHEP00000026069	Rho-associated, coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. (419 aa)
	amotl2	Angiomotin like 2a. (700 aa)
	LOC105926323	FERM domain-containing protein. (1698 aa)
	ENSFHEP00000029367	Uncharacterized protein. (464 aa)
	fhod3	Formin homology 2 domain containing 3b. (1530 aa)
	nckap1l	Uncharacterized protein. (1029 aa)
	LOC105934533	FERM domain-containing protein. (678 aa)
	anln	Anillin, actin binding protein. (1211 aa)
	LOC105929083	ADP-ribosylation factor 6b; Belongs to the small GTPase superfamily. Arf family. (184 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000000538	ENSFHEP00000025150	ENSFHEP00000000538	ENSFHEP00000025150	4_1_CTD domain-containing protein.	FERM domain-containing protein.	0.900
ENSFHEP00000004576	ENSFHEP00000029367	ENSFHEP00000004576	ENSFHEP00000029367	Uncharacterized protein.	Uncharacterized protein.	0.922
ENSFHEP00000004576	LLGL1	ENSFHEP00000004576	ENSFHEP00000004052	Uncharacterized protein.	LLGL scribble cell polarity complex component 1.	0.903
ENSFHEP00000010398	ENSFHEP00000019655	ENSFHEP00000010398	ENSFHEP00000019655	Formin_GBD_N domain-containing protein.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.407
ENSFHEP00000010398	ENSFHEP00000019697	ENSFHEP00000010398	ENSFHEP00000019697	Formin_GBD_N domain-containing protein.	Rho_Binding domain-containing protein.	0.407
ENSFHEP00000010398	ENSFHEP00000019719	ENSFHEP00000010398	ENSFHEP00000019719	Formin_GBD_N domain-containing protein.	Phorbol-ester/DAG-type domain-containing protein.	0.407
ENSFHEP00000010398	ENSFHEP00000026069	ENSFHEP00000010398	ENSFHEP00000026069	Formin_GBD_N domain-containing protein.	Rho-associated, coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily.	0.407
ENSFHEP00000010398	ROCK1	ENSFHEP00000010398	ENSFHEP00000022815	Formin_GBD_N domain-containing protein.	Rho associated coiled-coil containing protein kinase 1.	0.407
ENSFHEP00000010407	ENSFHEP00000010423	ENSFHEP00000010407	ENSFHEP00000010423	GBD/FH3 domain-containing protein.	Formin homology 2 domain containing 1.	0.627
ENSFHEP00000010407	ENSFHEP00000019655	ENSFHEP00000010407	ENSFHEP00000019655	GBD/FH3 domain-containing protein.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.407
ENSFHEP00000010407	ENSFHEP00000019697	ENSFHEP00000010407	ENSFHEP00000019697	GBD/FH3 domain-containing protein.	Rho_Binding domain-containing protein.	0.407
ENSFHEP00000010407	ENSFHEP00000019719	ENSFHEP00000010407	ENSFHEP00000019719	GBD/FH3 domain-containing protein.	Phorbol-ester/DAG-type domain-containing protein.	0.407
ENSFHEP00000010407	ENSFHEP00000026069	ENSFHEP00000010407	ENSFHEP00000026069	GBD/FH3 domain-containing protein.	Rho-associated, coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily.	0.407
ENSFHEP00000010407	ROCK1	ENSFHEP00000010407	ENSFHEP00000022815	GBD/FH3 domain-containing protein.	Rho associated coiled-coil containing protein kinase 1.	0.407
ENSFHEP00000010423	ENSFHEP00000010407	ENSFHEP00000010423	ENSFHEP00000010407	Formin homology 2 domain containing 1.	GBD/FH3 domain-containing protein.	0.627
ENSFHEP00000010423	ENSFHEP00000019655	ENSFHEP00000010423	ENSFHEP00000019655	Formin homology 2 domain containing 1.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.901
ENSFHEP00000010423	ENSFHEP00000019697	ENSFHEP00000010423	ENSFHEP00000019697	Formin homology 2 domain containing 1.	Rho_Binding domain-containing protein.	0.901
ENSFHEP00000010423	ENSFHEP00000019719	ENSFHEP00000010423	ENSFHEP00000019719	Formin homology 2 domain containing 1.	Phorbol-ester/DAG-type domain-containing protein.	0.901
ENSFHEP00000010423	ENSFHEP00000026069	ENSFHEP00000010423	ENSFHEP00000026069	Formin homology 2 domain containing 1.	Rho-associated, coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily.	0.483
ENSFHEP00000010423	ROCK1	ENSFHEP00000010423	ENSFHEP00000022815	Formin homology 2 domain containing 1.	Rho associated coiled-coil containing protein kinase 1.	0.483