47 items (Fundulus heteroclitus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	akt1s1	AKT1 substrate 1 (proline-rich). (353 aa)
	depdc5	DEP domain containing 5. (883 aa)
	LOC105932864	TBC1 domain family, member 7. (294 aa)
	MINAR1	Membrane integral NOTCH2 associated receptor 1. (813 aa)
	deptor	DEP domain containing MTOR-interacting protein. (404 aa)
	prkaa1	Non-specific serine/threonine protein kinase. (564 aa)
	ENSFHEP00000001710	DEP domain-containing protein. (103 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (436 aa)
	nprl3	Nitrogen permease regulator 3-like protein. (599 aa)
	tmem127	Transmembrane protein 127. (237 aa)
	ENSFHEP00000007615	Uncharacterized protein. (101 aa)
	ENSFHEP00000017412	Uncharacterized protein. (55 aa)
	nprl2	NPR2 like, GATOR1 complex subunit. (274 aa)
	ubr2	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1679 aa)
	LOC105925555	Sestrin 2. (558 aa)
	LOC105920118	Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily. (436 aa)
	fnip1	Folliculin interacting protein 1. (1223 aa)
	LOC105925715	Si:zfos-80g12.1. (371 aa)
	LOC105929493	CBM21 domain-containing protein. (1236 aa)
	bmt2	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (388 aa)
	flcn	Folliculin. (564 aa)
	gsk3b	Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (425 aa)
	ENSFHEP00000032812	Uncharacterized protein. (83 aa)
	mapkapk5	Protein kinase domain-containing protein. (440 aa)
	ENSFHEP00000032875	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (395 aa)
	ENSFHEP00000034851	TAN domain-containing protein. (173 aa)
	ENSFHEP00000020833	Uncharacterized protein. (136 aa)
	castor2	Cytosolic arginine sensor for mTORC1 subunit 2. (290 aa)
	sesn1	Sestrin 1. (548 aa)
	prkaa2	Non-specific serine/threonine protein kinase. (557 aa)
	LOC105919602	Si:dkeyp-97e7.9. (313 aa)
	itfg2	Integrin alpha FG-GAP repeat containing 2. (433 aa)
	kptn	Kaptin (actin binding protein). (442 aa)
	sirt1	Sirtuin 1. (719 aa)
	LOC105919467	TSC complex subunit 1. (1034 aa)
	cunh12orf66	Si:ch211-125a15.1. (450 aa)
	tsc2	TSC complex subunit 2. (1700 aa)
	sh3bp4	SH3-domain binding protein 4. (965 aa)
	gsk3a	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily. (440 aa)
	ENSFHEP00000009643	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (384 aa)
	ddit4	DNA-damage-inducible transcript 4. (225 aa)
	LOC105917024	SH3-domain binding protein 4a. (960 aa)
	LOC105927446	TSC complex subunit 1b. (1254 aa)
	ENSFHEP00000017385	Uncharacterized protein. (57 aa)
	rnf152	Ring finger protein 152. (173 aa)
	minar1	UPF0258 protein. (802 aa)
	CASTOR1	Cytosolic arginine sensor for mTORC1 subunit 1. (327 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASTOR1	ENSFHEP00000017385	ENSFHEP00000003587	ENSFHEP00000017385	Cytosolic arginine sensor for mTORC1 subunit 1.	Uncharacterized protein.	0.601
CASTOR1	ENSFHEP00000017412	ENSFHEP00000003587	ENSFHEP00000017412	Cytosolic arginine sensor for mTORC1 subunit 1.	Uncharacterized protein.	0.585
CASTOR1	castor2	ENSFHEP00000003587	ENSFHEP00000020866	Cytosolic arginine sensor for mTORC1 subunit 1.	Cytosolic arginine sensor for mTORC1 subunit 2.	0.970
CASTOR1	cunh12orf66	ENSFHEP00000003587	ENSFHEP00000008451	Cytosolic arginine sensor for mTORC1 subunit 1.	Si:ch211-125a15.1.	0.734
CASTOR1	depdc5	ENSFHEP00000003587	ENSFHEP00000005599	Cytosolic arginine sensor for mTORC1 subunit 1.	DEP domain containing 5.	0.699
CASTOR1	itfg2	ENSFHEP00000003587	ENSFHEP00000022768	Cytosolic arginine sensor for mTORC1 subunit 1.	Integrin alpha FG-GAP repeat containing 2.	0.736
CASTOR1	kptn	ENSFHEP00000003587	ENSFHEP00000023518	Cytosolic arginine sensor for mTORC1 subunit 1.	Kaptin (actin binding protein).	0.708
CASTOR1	nprl2	ENSFHEP00000003587	ENSFHEP00000017420	Cytosolic arginine sensor for mTORC1 subunit 1.	NPR2 like, GATOR1 complex subunit.	0.601
CASTOR1	nprl3	ENSFHEP00000003587	ENSFHEP00000001816	Cytosolic arginine sensor for mTORC1 subunit 1.	Nitrogen permease regulator 3-like protein.	0.680
ENSFHEP00000001710	akt1s1	ENSFHEP00000001710	ENSFHEP00000004883	DEP domain-containing protein.	AKT1 substrate 1 (proline-rich).	0.935
ENSFHEP00000001710	deptor	ENSFHEP00000001710	ENSFHEP00000001079	DEP domain-containing protein.	DEP domain containing MTOR-interacting protein.	0.898
ENSFHEP00000009643	ENSFHEP00000032875	ENSFHEP00000009643	ENSFHEP00000032875	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	0.916
ENSFHEP00000017385	CASTOR1	ENSFHEP00000017385	ENSFHEP00000003587	Uncharacterized protein.	Cytosolic arginine sensor for mTORC1 subunit 1.	0.601
ENSFHEP00000017385	LOC105925555	ENSFHEP00000017385	ENSFHEP00000025442	Uncharacterized protein.	Sestrin 2.	0.676
ENSFHEP00000017385	LOC105925715	ENSFHEP00000017385	ENSFHEP00000030078	Uncharacterized protein.	Si:zfos-80g12.1.	0.643
ENSFHEP00000017385	LOC105929493	ENSFHEP00000017385	ENSFHEP00000030237	Uncharacterized protein.	CBM21 domain-containing protein.	0.695
ENSFHEP00000017385	LOC105932864	ENSFHEP00000017385	ENSFHEP00000005989	Uncharacterized protein.	TBC1 domain family, member 7.	0.437
ENSFHEP00000017385	bmt2	ENSFHEP00000017385	ENSFHEP00000030241	Uncharacterized protein.	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	0.695
ENSFHEP00000017385	cunh12orf66	ENSFHEP00000017385	ENSFHEP00000008451	Uncharacterized protein.	Si:ch211-125a15.1.	0.977
ENSFHEP00000017385	depdc5	ENSFHEP00000017385	ENSFHEP00000005599	Uncharacterized protein.	DEP domain containing 5.	0.996