(35 nodes) Positive regulation of TOR signaling network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	lamtor4	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4. (162 aa)
	LOC105916159	G protein-coupled receptor 137c. (449 aa)
	clec16a	C-type lectin domain containing 16A. (935 aa)
	lamtor1	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (160 aa)
	LOC105927798	Ras-related GTP binding A. (315 aa)
	slc38a9	Solute carrier family 38 member 9. (558 aa)
	golph3	Si:dkey-27b3.2. (294 aa)
	RELN	Reelin. (3373 aa)
	LOC105930296	WW domain-containing protein. (529 aa)
	seh1l	SEH1-like (S. cerevisiae); Belongs to the WD repeat SEC13 family. (383 aa)
	rictor	RPTOR independent companion of MTOR, complex 2 a. (1659 aa)
	klhl22	Kelch-like family member 22. (640 aa)
	rragc	Ras-related GTP binding Ca. (262 aa)
	sec13	SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (320 aa)
	lamtor3	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa)
	fnip1	Folliculin interacting protein 1. (1223 aa)
	gas6	Uncharacterized protein. (650 aa)
	ENSFHEP00000008829	Uncharacterized protein. (252 aa)
	ENSFHEP00000006808	Uncharacterized protein. (159 aa)
	GPR137B	G protein-coupled receptor 137B. (386 aa)
	lamtor5	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (94 aa)
	LOC105924112	Uncharacterized protein. (185 aa)
	rptor	Regulatory associated protein of MTOR, complex 1. (1250 aa)
	lamtor2	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (165 aa)
	wac	WW domain containing adaptor with coiled-coil a. (541 aa)
	wdr24	WD repeat domain 24. (706 aa)
	LOC105919479	G protein-coupled receptor 137. (378 aa)
	mios	Missing oocyte, meiosis regulator, homolog (Drosophila). (855 aa)
	flcn	Folliculin. (564 aa)
	ENSFHEP00000031995	Uncharacterized protein. (83 aa)
	ENSFHEP00000034479	Uncharacterized protein. (67 aa)
	ENSFHEP00000011014	Golgi phosphoprotein 3. (100 aa)
	LOC105925901	5-hydroxytryptamine (serotonin) receptor 6; Belongs to the G-protein coupled receptor 1 family. (451 aa)
	lars1	Leucyl-tRNA synthetase b; Belongs to the class-I aminoacyl-tRNA synthetase family. (1068 aa)
	wdr59	WD repeat domain 59. (941 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000011014	LOC105924112	ENSFHEP00000011014	ENSFHEP00000003637	Golgi phosphoprotein 3.	Uncharacterized protein.	0.919
ENSFHEP00000031995	ENSFHEP00000034479	ENSFHEP00000031995	ENSFHEP00000034479	Uncharacterized protein.	Uncharacterized protein.	0.905
ENSFHEP00000031995	LOC105927798	ENSFHEP00000031995	ENSFHEP00000022033	Uncharacterized protein.	Ras-related GTP binding A.	0.993
ENSFHEP00000031995	flcn	ENSFHEP00000031995	ENSFHEP00000030845	Uncharacterized protein.	Folliculin.	0.980
ENSFHEP00000031995	fnip1	ENSFHEP00000031995	ENSFHEP00000028870	Uncharacterized protein.	Folliculin interacting protein 1.	0.915
ENSFHEP00000031995	lamtor1	ENSFHEP00000031995	ENSFHEP00000022602	Uncharacterized protein.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	0.984
ENSFHEP00000031995	lamtor2	ENSFHEP00000031995	ENSFHEP00000002231	Uncharacterized protein.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2.	0.985
ENSFHEP00000031995	lamtor3	ENSFHEP00000031995	ENSFHEP00000014303	Uncharacterized protein.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3.	0.983
ENSFHEP00000031995	lamtor4	ENSFHEP00000031995	ENSFHEP00000035100	Uncharacterized protein.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4.	0.950
ENSFHEP00000031995	lamtor5	ENSFHEP00000031995	ENSFHEP00000004077	Uncharacterized protein.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5.	0.986
ENSFHEP00000031995	lars1	ENSFHEP00000031995	ENSFHEP00000008938	Uncharacterized protein.	Leucyl-tRNA synthetase b; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.490
ENSFHEP00000031995	mios	ENSFHEP00000031995	ENSFHEP00000008653	Uncharacterized protein.	Missing oocyte, meiosis regulator, homolog (Drosophila).	0.935
ENSFHEP00000031995	rictor	ENSFHEP00000031995	ENSFHEP00000027330	Uncharacterized protein.	RPTOR independent companion of MTOR, complex 2 a.	0.414
ENSFHEP00000031995	rptor	ENSFHEP00000031995	ENSFHEP00000002240	Uncharacterized protein.	Regulatory associated protein of MTOR, complex 1.	0.990
ENSFHEP00000031995	sec13	ENSFHEP00000031995	ENSFHEP00000014441	Uncharacterized protein.	SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family.	0.690
ENSFHEP00000031995	seh1l	ENSFHEP00000031995	ENSFHEP00000017046	Uncharacterized protein.	SEH1-like (S. cerevisiae); Belongs to the WD repeat SEC13 family.	0.751
ENSFHEP00000031995	slc38a9	ENSFHEP00000031995	ENSFHEP00000021982	Uncharacterized protein.	Solute carrier family 38 member 9.	0.927
ENSFHEP00000031995	wdr24	ENSFHEP00000031995	ENSFHEP00000000983	Uncharacterized protein.	WD repeat domain 24.	0.949
ENSFHEP00000031995	wdr59	ENSFHEP00000031995	ENSFHEP00000025365	Uncharacterized protein.	WD repeat domain 59.	0.763
ENSFHEP00000034479	ENSFHEP00000031995	ENSFHEP00000034479	ENSFHEP00000031995	Uncharacterized protein.	Uncharacterized protein.	0.905