(16 nodes) Response to ATP network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	p2ry12	Purinergic receptor P2Y12. (357 aa)
	LOC105939307	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (406 aa)
	DGKQ	Diacylglycerol kinase. (783 aa)
	hsp90b1	Heat shock protein 90, beta (grp94), member 1. (863 aa)
	LOC105920712	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (418 aa)
	LOC105936110	Potassium inwardly-rectifying channel, subfamily J, member 8. (418 aa)
	ENSFHEP00000009949	Potassium inwardly-rectifying channel, subfamily J, member 11. (409 aa)
	ENSFHEP00000010216	Uncharacterized protein. (49 aa)
	panx1	Pannexin; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family. (421 aa)
	LOC105930221	Pannexin; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family. (440 aa)
	ENSFHEP00000027816	Uncharacterized protein. (162 aa)
	p2rx3	Uncharacterized protein. (328 aa)
	p2rx5	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (463 aa)
	LOC105934356	5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (528 aa)
	p2rx2	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (418 aa)
	p2rx7	Purinergic receptor P2X, ligand-gated ion channel, 7. (615 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000010216	LOC105920712	ENSFHEP00000010216	ENSFHEP00000006925	Uncharacterized protein.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.816
ENSFHEP00000010216	LOC105939307	ENSFHEP00000010216	ENSFHEP00000004850	Uncharacterized protein.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.823
ENSFHEP00000010216	p2rx2	ENSFHEP00000010216	ENSFHEP00000028682	Uncharacterized protein.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.829
ENSFHEP00000010216	p2rx5	ENSFHEP00000010216	ENSFHEP00000028099	Uncharacterized protein.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.770
ENSFHEP00000010216	p2rx7	ENSFHEP00000010216	ENSFHEP00000034153	Uncharacterized protein.	Purinergic receptor P2X, ligand-gated ion channel, 7.	0.758
ENSFHEP00000027816	LOC105920712	ENSFHEP00000027816	ENSFHEP00000006925	Uncharacterized protein.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.816
ENSFHEP00000027816	LOC105939307	ENSFHEP00000027816	ENSFHEP00000004850	Uncharacterized protein.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.823
ENSFHEP00000027816	p2rx2	ENSFHEP00000027816	ENSFHEP00000028682	Uncharacterized protein.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.829
ENSFHEP00000027816	p2rx5	ENSFHEP00000027816	ENSFHEP00000028099	Uncharacterized protein.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.770
ENSFHEP00000027816	p2rx7	ENSFHEP00000027816	ENSFHEP00000034153	Uncharacterized protein.	Purinergic receptor P2X, ligand-gated ion channel, 7.	0.758
LOC105920712	ENSFHEP00000010216	ENSFHEP00000006925	ENSFHEP00000010216	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	Uncharacterized protein.	0.816
LOC105920712	ENSFHEP00000027816	ENSFHEP00000006925	ENSFHEP00000027816	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	Uncharacterized protein.	0.816
LOC105920712	LOC105930221	ENSFHEP00000006925	ENSFHEP00000018599	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	Pannexin; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family.	0.664
LOC105920712	LOC105939307	ENSFHEP00000006925	ENSFHEP00000004850	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.903
LOC105920712	p2rx2	ENSFHEP00000006925	ENSFHEP00000028682	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.873
LOC105920712	p2rx3	ENSFHEP00000006925	ENSFHEP00000027888	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	Uncharacterized protein.	0.831
LOC105920712	p2rx5	ENSFHEP00000006925	ENSFHEP00000028099	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.850
LOC105920712	p2rx7	ENSFHEP00000006925	ENSFHEP00000034153	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	Purinergic receptor P2X, ligand-gated ion channel, 7.	0.909
LOC105920712	p2ry12	ENSFHEP00000006925	ENSFHEP00000031523	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	Purinergic receptor P2Y12.	0.633
LOC105920712	panx1	ENSFHEP00000006925	ENSFHEP00000014305	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	Pannexin; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family.	0.664