38 items (Fundulus heteroclitus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	bmt2	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (388 aa)
	impact	Impact RWD domain protein. (339 aa)
	LOC105929477	Si:ch211-153j24.3. (318 aa)
	wdr24	WD repeat domain 24. (706 aa)
	nprl3	Nitrogen permease regulator 3-like protein. (599 aa)
	rnf152	Ring finger protein 152. (173 aa)
	dap	Death-associated protein. (105 aa)
	gcn1	GCN1 activator of EIF2AK4. (2578 aa)
	depdc5	DEP domain containing 5. (883 aa)
	eif2ak3	Eukaryotic translation initiation factor 2-alpha kinase 3. (1136 aa)
	ENSFHEP00000007615	Uncharacterized protein. (101 aa)
	cunh12orf66	Si:ch211-125a15.1. (450 aa)
	mios	Missing oocyte, meiosis regulator, homolog (Drosophila). (855 aa)
	lars1	Leucyl-tRNA synthetase b; Belongs to the class-I aminoacyl-tRNA synthetase family. (1068 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2495 aa)
	rragc	Ras-related GTP binding Ca. (262 aa)
	seh1l	SEH1-like (S. cerevisiae); Belongs to the WD repeat SEC13 family. (383 aa)
	ENSFHEP00000017385	Uncharacterized protein. (57 aa)
	nprl2	NPR2 like, GATOR1 complex subunit. (274 aa)
	tfeb	Transcription factor EB. (539 aa)
	dapl1	Death associated protein 1b. (111 aa)
	ENSFHEP00000020686	DRBM domain-containing protein. (159 aa)
	sesn1	Sestrin 1. (548 aa)
	LOC105940240	Uncharacterized protein. (314 aa)
	LOC105927798	Ras-related GTP binding A. (315 aa)
	itfg2	Integrin alpha FG-GAP repeat containing 2. (433 aa)
	eif2s1	Eukaryotic translation initiation factor 2, subunit 1 alpha b. (315 aa)
	kptn	Kaptin (actin binding protein). (442 aa)
	wdr59	WD repeat domain 59. (941 aa)
	LOC105925555	Sestrin 2. (558 aa)
	LOC105915402	Activating transcription factor 4a. (442 aa)
	atf3	Activating transcription factor 3. (213 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1654 aa)
	LOC105925715	Si:zfos-80g12.1. (371 aa)
	LOC105929493	CBM21 domain-containing protein. (1236 aa)
	flcn	Folliculin. (564 aa)
	ENSFHEP00000031995	Uncharacterized protein. (83 aa)
	ENSFHEP00000034479	Uncharacterized protein. (67 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF2AK4	ENSFHEP00000020686	ENSFHEP00000029640	ENSFHEP00000020686	Eukaryotic translation initiation factor 2 alpha kinase 4.	DRBM domain-containing protein.	0.809
EIF2AK4	LOC105915402	ENSFHEP00000029640	ENSFHEP00000027151	Eukaryotic translation initiation factor 2 alpha kinase 4.	Activating transcription factor 4a.	0.583
EIF2AK4	LOC105927798	ENSFHEP00000029640	ENSFHEP00000022033	Eukaryotic translation initiation factor 2 alpha kinase 4.	Ras-related GTP binding A.	0.529
EIF2AK4	eif2ak3	ENSFHEP00000029640	ENSFHEP00000006976	Eukaryotic translation initiation factor 2 alpha kinase 4.	Eukaryotic translation initiation factor 2-alpha kinase 3.	0.962
EIF2AK4	eif2s1	ENSFHEP00000029640	ENSFHEP00000022871	Eukaryotic translation initiation factor 2 alpha kinase 4.	Eukaryotic translation initiation factor 2, subunit 1 alpha b.	0.997
EIF2AK4	gcn1	ENSFHEP00000029640	ENSFHEP00000003837	Eukaryotic translation initiation factor 2 alpha kinase 4.	GCN1 activator of EIF2AK4.	0.880
EIF2AK4	impact	ENSFHEP00000029640	ENSFHEP00000000388	Eukaryotic translation initiation factor 2 alpha kinase 4.	Impact RWD domain protein.	0.548
EIF2AK4	lars1	ENSFHEP00000029640	ENSFHEP00000008938	Eukaryotic translation initiation factor 2 alpha kinase 4.	Leucyl-tRNA synthetase b; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.690
EIF2AK4	mtor	ENSFHEP00000029640	ENSFHEP00000010587	Eukaryotic translation initiation factor 2 alpha kinase 4.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.921
ENSFHEP00000017385	ENSFHEP00000031995	ENSFHEP00000017385	ENSFHEP00000031995	Uncharacterized protein.	Uncharacterized protein.	0.838
ENSFHEP00000017385	ENSFHEP00000034479	ENSFHEP00000017385	ENSFHEP00000034479	Uncharacterized protein.	Uncharacterized protein.	0.838
ENSFHEP00000017385	LOC105925555	ENSFHEP00000017385	ENSFHEP00000025442	Uncharacterized protein.	Sestrin 2.	0.676
ENSFHEP00000017385	LOC105925715	ENSFHEP00000017385	ENSFHEP00000030078	Uncharacterized protein.	Si:zfos-80g12.1.	0.643
ENSFHEP00000017385	LOC105927798	ENSFHEP00000017385	ENSFHEP00000022033	Uncharacterized protein.	Ras-related GTP binding A.	0.995
ENSFHEP00000017385	LOC105929493	ENSFHEP00000017385	ENSFHEP00000030237	Uncharacterized protein.	CBM21 domain-containing protein.	0.695
ENSFHEP00000017385	bmt2	ENSFHEP00000017385	ENSFHEP00000030241	Uncharacterized protein.	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	0.695
ENSFHEP00000017385	cunh12orf66	ENSFHEP00000017385	ENSFHEP00000008451	Uncharacterized protein.	Si:ch211-125a15.1.	0.977
ENSFHEP00000017385	depdc5	ENSFHEP00000017385	ENSFHEP00000005599	Uncharacterized protein.	DEP domain containing 5.	0.996
ENSFHEP00000017385	flcn	ENSFHEP00000017385	ENSFHEP00000030845	Uncharacterized protein.	Folliculin.	0.512
ENSFHEP00000017385	itfg2	ENSFHEP00000017385	ENSFHEP00000022768	Uncharacterized protein.	Integrin alpha FG-GAP repeat containing 2.	0.980