58 items (Fundulus heteroclitus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	nfatc4	Nuclear factor of activated T cells 4. (897 aa)
	LOC105917239	Fibrinogen C-terminal domain-containing protein. (235 aa)
	noc2l	NOC2-like nucleolar associated transcriptional repressor. (742 aa)
	LOC105931725	Mitogen-activated protein kinase. (360 aa)
	sirt1	Sirtuin 1. (719 aa)
	LOC105937904	Fibrinogen C-terminal domain-containing protein. (240 aa)
	aqp1	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (294 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (834 aa)
	xpa	Xeroderma pigmentosum, complementation group A. (275 aa)
	ENSFHEP00000029097	Opsin 5; Belongs to the G-protein coupled receptor 1 family. (322 aa)
	tp53inp1	Tumor protein p53 inducible nuclear protein 1. (286 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1654 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (290 aa)
	ENSFHEP00000029950	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (293 aa)
	xpc	Xeroderma pigmentosum, complementation group C. (748 aa)
	chek1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (454 aa)
	casp9	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (436 aa)
	cul4b	Cullin 4B; Belongs to the cullin family. (868 aa)
	LOC105924716	Fibrinogen C-terminal domain-containing protein. (133 aa)
	LOC105934240	Mitogen-activated protein kinase. (364 aa)
	ENSFHEP00000033293	Uncharacterized protein. (212 aa)
	pold1	DNA polymerase. (1152 aa)
	tmem161a	Transmembrane protein 161A. (496 aa)
	ddb1	Damage-specific DNA binding protein 1. (1030 aa)
	LOC105923468	Fibrinogen C-terminal domain-containing protein. (139 aa)
	ercc1	Excision repair cross-complementation group 1. (366 aa)
	polk	Polymerase (DNA directed) kappa. (509 aa)
	usp47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1377 aa)
	bax	Uncharacterized protein. (240 aa)
	LOC105931778	Mitogen-activated protein kinase. (357 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (436 aa)
	actr5	Actin-related protein 5; Belongs to the actin family. (622 aa)
	parp1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1015 aa)
	impact	Impact RWD domain protein. (339 aa)
	LOC105933792	Cullin 4A; Belongs to the cullin family. (653 aa)
	LOC105924936	CREB binding protein b. (2424 aa)
	crebbp	CREB binding protein a. (2270 aa)
	bmf	Uncharacterized protein. (174 aa)
	LOC105930854	E1A binding protein p300 a. (2838 aa)
	mettl3	Methyltransferase like 3; Belongs to the MT-A70-like family. (578 aa)
	ercc4	Excision repair cross-complementation group 4. (897 aa)
	atr	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2414 aa)
	dhx36	DEAH (Asp-Glu-Ala-His) box polypeptide 36. (1013 aa)
	smpd1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (630 aa)
	ppid	Peptidylprolyl isomerase D. (371 aa)
	MFAP4	Microfibril associated protein 4. (232 aa)
	rhbdd1	Rhomboid domain containing 1. (323 aa)
	ENSFHEP00000018863	Uncharacterized protein. (153 aa)
	ENSFHEP00000018936	Opsin 8, group member b; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (346 aa)
	ep300	E1A binding protein p300 b. (2738 aa)
	ENSFHEP00000019419	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (323 aa)
	opn3	Opsin 3. (389 aa)
	rhno1	Si:ch73-352p4.5. (291 aa)
	LOC105923467	Fibrinogen C-terminal domain-containing protein. (138 aa)
	polh	Polymerase (DNA directed), eta. (721 aa)
	cops9	COP9 signalosome subunit 9. (57 aa)
	eif2s1	Eukaryotic translation initiation factor 2, subunit 1 alpha b. (315 aa)
	LOC105934504	Fibrinogen C-terminal domain-containing protein. (240 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF2AK4	eif2s1	ENSFHEP00000029640	ENSFHEP00000022871	Eukaryotic translation initiation factor 2 alpha kinase 4.	Eukaryotic translation initiation factor 2, subunit 1 alpha b.	0.997
EIF2AK4	impact	ENSFHEP00000029640	ENSFHEP00000000388	Eukaryotic translation initiation factor 2 alpha kinase 4.	Impact RWD domain protein.	0.548
EIF2AK4	sirt1	ENSFHEP00000029640	ENSFHEP00000025372	Eukaryotic translation initiation factor 2 alpha kinase 4.	Sirtuin 1.	0.439
ENSFHEP00000018863	bax	ENSFHEP00000018863	ENSFHEP00000004805	Uncharacterized protein.	Uncharacterized protein.	0.972
ENSFHEP00000018863	bmf	ENSFHEP00000018863	ENSFHEP00000013064	Uncharacterized protein.	Uncharacterized protein.	0.649
ENSFHEP00000018863	casp9	ENSFHEP00000018863	ENSFHEP00000031395	Uncharacterized protein.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.565
ENSFHEP00000018863	sirt1	ENSFHEP00000018863	ENSFHEP00000025372	Uncharacterized protein.	Sirtuin 1.	0.476
ENSFHEP00000018936	opn3	ENSFHEP00000018936	ENSFHEP00000019711	Opsin 8, group member b; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.	Opsin 3.	0.594
ENSFHEP00000029097	opn3	ENSFHEP00000029097	ENSFHEP00000019711	Opsin 5; Belongs to the G-protein coupled receptor 1 family.	Opsin 3.	0.513
ENSFHEP00000029950	noc2l	ENSFHEP00000029950	ENSFHEP00000024283	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	NOC2-like nucleolar associated transcriptional repressor.	0.693
ENSFHEP00000029950	pold1	ENSFHEP00000029950	ENSFHEP00000033611	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	DNA polymerase.	0.471
ENSFHEP00000033293	LOC105933792	ENSFHEP00000033293	ENSFHEP00000008575	Uncharacterized protein.	Cullin 4A; Belongs to the cullin family.	0.622
ENSFHEP00000033293	actr5	ENSFHEP00000033293	ENSFHEP00000001096	Uncharacterized protein.	Actin-related protein 5; Belongs to the actin family.	0.993
ENSFHEP00000033293	atr	ENSFHEP00000033293	ENSFHEP00000015732	Uncharacterized protein.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.407
ENSFHEP00000033293	cul4b	ENSFHEP00000033293	ENSFHEP00000031654	Uncharacterized protein.	Cullin 4B; Belongs to the cullin family.	0.622
ENSFHEP00000033293	ddb1	ENSFHEP00000033293	ENSFHEP00000034388	Uncharacterized protein.	Damage-specific DNA binding protein 1.	0.718
ENSFHEP00000033293	ercc4	ENSFHEP00000033293	ENSFHEP00000015698	Uncharacterized protein.	Excision repair cross-complementation group 4.	0.478
ENSFHEP00000033293	kdm1a	ENSFHEP00000033293	ENSFHEP00000028103	Uncharacterized protein.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.440
ENSFHEP00000033293	pold1	ENSFHEP00000033293	ENSFHEP00000033611	Uncharacterized protein.	DNA polymerase.	0.442
ENSFHEP00000033293	polh	ENSFHEP00000033293	ENSFHEP00000021919	Uncharacterized protein.	Polymerase (DNA directed), eta.	0.475