(86 nodes) Appendage morphogenesis network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	bax	Uncharacterized protein. (240 aa)
	LOC105923943	Asp-B-Hydro_N domain-containing protein. (201 aa)
	bcl2l11	Uncharacterized protein. (239 aa)
	crbn	Cereblon. (449 aa)
	LOC105937983	FRAS1 related extracellular matrix 2b. (2967 aa)
	sall3	Spalt-like transcription factor 3a. (1256 aa)
	vgll2	Vestigial-like family member 2a. (288 aa)
	ENSFHEP00000009221	Uncharacterized protein. (268 aa)
	ENSFHEP00000009896	WD repeat-containing and planar cell polarity effector protein fritz. (447 aa)
	LOC105926883	Uncharacterized protein. (529 aa)
	fras1	Fraser extracellular matrix complex subunit 1. (3625 aa)
	atrx	ATRX chromatin remodeler. (1852 aa)
	msx1	Muscle segment homeobox 1a. (281 aa)
	LOC105920529	Mothers against decapentaplegic homolog. (520 aa)
	gja1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (387 aa)
	sall4	Spalt-like transcription factor 4. (1083 aa)
	LOC105921120	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (643 aa)
	ENSFHEP00000013148	Sp8 transcription factor b. (440 aa)
	LOC110366481	Uncharacterized protein. (209 aa)
	ENSFHEP00000013800	Gremlin 1a, DAN family BMP antagonist. (181 aa)
	LOC105930363	Si:dkey-91i10.2. (1190 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1792 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	dlx5	Distal-less homeobox 5a. (286 aa)
	ENSFHEP00000014677	Uncharacterized protein. (104 aa)
	LOC105916912	Spalt-like transcription factor 3b. (1134 aa)
	LOC105917506	Uncharacterized protein. (606 aa)
	LOC105930785	T-box transcription factor 5a. (524 aa)
	ENSFHEP00000016962	RPGRIP1 like. (885 aa)
	LOC105930806	Nipped-B protein. (2737 aa)
	en1	Homeobox protein engrailed-like. (284 aa)
	ENSFHEP00000017921	Growth arrest-specific 1b. (243 aa)
	LOC105938216	DUF3736 domain-containing protein. (1153 aa)
	ENSFHEP00000018863	Uncharacterized protein. (153 aa)
	ENSFHEP00000019104	Uncharacterized protein. (105 aa)
	mks1	MKS transition zone complex subunit 1. (506 aa)
	gse1	Gse1 coiled-coil protein. (2124 aa)
	chrd	Chordin; Belongs to the chordin family. (1031 aa)
	ENSFHEP00000019886	Uncharacterized protein. (184 aa)
	tbx4	T-box transcription factor 4. (512 aa)
	fbxw4	F-box and WD repeat domain containing 4. (389 aa)
	ift140	Intraflagellar transport 140 homolog (Chlamydomonas). (1446 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	ENSFHEP00000023812	Uncharacterized protein. (139 aa)
	ENSFHEP00000023885	Muscle segment homeobox 3. (247 aa)
	LOC105917232	SAM domain-containing protein. (555 aa)
	lef1	Lymphoid enhancer-binding factor 1. (424 aa)
	ENSFHEP00000025036	Asp-B-Hydro_N domain-containing protein. (238 aa)
	ENSFHEP00000025299	Ring finger protein 165a. (345 aa)
	pkdcc	Protein kinase domain containing, cytoplasmic b. (493 aa)
	frem3	Fras1 related extracellular matrix 3. (3050 aa)
	FBLN1	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (863 aa)
	wdr19	WD repeat domain 19. (1343 aa)
	ENSFHEP00000026670	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (127 aa)
	tll1	Metalloendopeptidase. (937 aa)
	ENSFHEP00000027612	Uncharacterized protein. (86 aa)
	ENSFHEP00000027796	Uncharacterized protein. (281 aa)
	fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (236 aa)
	FKBP14	Peptidylprolyl isomerase. (209 aa)
	GREM1	Gremlin 1, DAN family BMP antagonist. (153 aa)
	LOC110368549	Peptidylprolyl isomerase. (122 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (905 aa)
	dlx6	Distal-less homeobox 6a. (246 aa)
	LOC105939942	Nipped-B protein. (2440 aa)
	ift52	Intraflagellar transport 52 homolog (Chlamydomonas). (434 aa)
	tbx3	T-box transcription factor 3a. (764 aa)
	LOC105931390	Ring finger protein 165b. (349 aa)
	LOC105934231	Protein kinase domain-containing protein. (674 aa)
	bmp1	Metalloendopeptidase. (970 aa)
	LOC105930774	Mothers against decapentaplegic homolog. (393 aa)
	ENSFHEP00000033024	Uncharacterized protein. (61 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
	ENSFHEP00000033985	Fin bud initiation factor b. (197 aa)
	ENSFHEP00000034755	MH1 domain-containing protein. (154 aa)
	LOC105921341	MH2 domain-containing protein. (222 aa)
	hoxc4	Homeobox C10a. (481 aa)
	LOC105940217	Dickkopf WNT signaling pathway inhibitor 1a. (261 aa)
	ENSFHEP00000001303	Uncharacterized protein. (1401 aa)
	ENSFHEP00000001893	Uncharacterized protein. (199 aa)
	LOC105923386	Secreted frizzled-related protein 2 like. (342 aa)
	sema3c	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C; Belongs to the semaphorin family. (887 aa)
	sall1	Spalt-like transcription factor 1a. (1307 aa)
	ENSFHEP00000003392	Heart and neural crest derivatives expressed 2. (235 aa)
	sec23a	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (764 aa)
	ENSFHEP00000004336	Uncharacterized protein. (1255 aa)
	sp9	Sp9 transcription factor. (439 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDH2	gja1	ENSFHEP00000030344	ENSFHEP00000011745	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.698
ENSFHEP00000001303	ENSFHEP00000014677	ENSFHEP00000001303	ENSFHEP00000014677	Uncharacterized protein.	Uncharacterized protein.	0.531
ENSFHEP00000001303	LOC105930806	ENSFHEP00000001303	ENSFHEP00000017356	Uncharacterized protein.	Nipped-B protein.	0.531
ENSFHEP00000001303	LOC105939942	ENSFHEP00000001303	ENSFHEP00000030843	Uncharacterized protein.	Nipped-B protein.	0.531
ENSFHEP00000001893	ENSFHEP00000004336	ENSFHEP00000001893	ENSFHEP00000004336	Uncharacterized protein.	Uncharacterized protein.	0.528
ENSFHEP00000001893	ENSFHEP00000027796	ENSFHEP00000001893	ENSFHEP00000027796	Uncharacterized protein.	Uncharacterized protein.	0.732
ENSFHEP00000001893	LOC105937983	ENSFHEP00000001893	ENSFHEP00000007204	Uncharacterized protein.	FRAS1 related extracellular matrix 2b.	0.880
ENSFHEP00000001893	fras1	ENSFHEP00000001893	ENSFHEP00000011015	Uncharacterized protein.	Fraser extracellular matrix complex subunit 1.	0.846
ENSFHEP00000003392	ENSFHEP00000023812	ENSFHEP00000003392	ENSFHEP00000023812	Heart and neural crest derivatives expressed 2.	Uncharacterized protein.	0.401
ENSFHEP00000003392	LOC105926883	ENSFHEP00000003392	ENSFHEP00000010411	Heart and neural crest derivatives expressed 2.	Uncharacterized protein.	0.505
ENSFHEP00000003392	LOC105930785	ENSFHEP00000003392	ENSFHEP00000016655	Heart and neural crest derivatives expressed 2.	T-box transcription factor 5a.	0.669
ENSFHEP00000003392	dlx5	ENSFHEP00000003392	ENSFHEP00000014533	Heart and neural crest derivatives expressed 2.	Distal-less homeobox 5a.	0.424
ENSFHEP00000003392	dlx6	ENSFHEP00000003392	ENSFHEP00000030677	Heart and neural crest derivatives expressed 2.	Distal-less homeobox 6a.	0.426
ENSFHEP00000003392	shh	ENSFHEP00000003392	ENSFHEP00000014527	Heart and neural crest derivatives expressed 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.464
ENSFHEP00000003392	tbx4	ENSFHEP00000003392	ENSFHEP00000021300	Heart and neural crest derivatives expressed 2.	T-box transcription factor 4.	0.487
ENSFHEP00000004336	ENSFHEP00000001893	ENSFHEP00000004336	ENSFHEP00000001893	Uncharacterized protein.	Uncharacterized protein.	0.528
ENSFHEP00000004336	ENSFHEP00000027796	ENSFHEP00000004336	ENSFHEP00000027796	Uncharacterized protein.	Uncharacterized protein.	0.890
ENSFHEP00000004336	fras1	ENSFHEP00000004336	ENSFHEP00000011015	Uncharacterized protein.	Fraser extracellular matrix complex subunit 1.	0.656
ENSFHEP00000009221	ENSFHEP00000017921	ENSFHEP00000009221	ENSFHEP00000017921	Uncharacterized protein.	Growth arrest-specific 1b.	0.905
ENSFHEP00000009221	shh	ENSFHEP00000009221	ENSFHEP00000014527	Uncharacterized protein.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.949