(38 nodes) Embryonic hemopoiesis network (Fundulus heteroclitus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	yap1	Yes-associated protein 1. (429 aa)
	LOC105929438	Myc target protein 1. (200 aa)
	LOC105940274	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (673 aa)
	LOC105934050	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (664 aa)
	LOC105919611	GATA binding protein 1a. (424 aa)
	PRKCB	Protein kinase C. (647 aa)
	cftr	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1503 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (540 aa)
	LOC105925877	Tripartite motif containing 33. (1194 aa)
	phykpl	5-phosphohydroxy-L-lysine phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (461 aa)
	gja1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (387 aa)
	LOC105926306	Histone deacetylase 9b. (559 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1792 aa)
	LOC105934993	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (631 aa)
	LOC105926861	Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family. (338 aa)
	nop10	NOP10 ribonucleoprotein homolog (yeast). (64 aa)
	chrd	Chordin; Belongs to the chordin family. (1031 aa)
	rps24	40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family. (139 aa)
	ism1	Isthmin 1. (451 aa)
	ENSFHEP00000022320	BHLH domain-containing protein. (129 aa)
	hhex	Homeobox domain-containing protein. (288 aa)
	NCOA2	Nuclear receptor coactivator. (1494 aa)
	ccdc134	Si:dkey-167k11.5. (229 aa)
	lmo2	LIM domain only 2 (rhombotin-like 1). (156 aa)
	tll1	Metalloendopeptidase. (937 aa)
	slc40a1	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (565 aa)
	LOC105915402	Activating transcription factor 4a. (442 aa)
	LOC105920540	Uncharacterized protein. (271 aa)
	tbx20	T-box transcription factor 20. (439 aa)
	LOC105929932	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
	LOC105933755	5-aminolevulinate synthase. (554 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
	ncoa2	Nuclear receptor coactivator. (1446 aa)
	LOC105935913	T-cell acute lymphocytic leukemia protein 1. (478 aa)
	bmp1	Metalloendopeptidase. (970 aa)
	sh2b3	SH2B adaptor protein 3. (717 aa)
	lclat1	Lysocardiolipin acyltransferase 1. (381 aa)
	etnppl	Ethanolamine-phosphate phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (446 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000022320	LOC105919611	ENSFHEP00000022320	ENSFHEP00000001731	BHLH domain-containing protein.	GATA binding protein 1a.	0.844
ENSFHEP00000022320	LOC105920540	ENSFHEP00000022320	ENSFHEP00000028444	BHLH domain-containing protein.	Uncharacterized protein.	0.844
ENSFHEP00000022320	lmo2	ENSFHEP00000022320	ENSFHEP00000026291	BHLH domain-containing protein.	LIM domain only 2 (rhombotin-like 1).	0.984
LOC105919611	ENSFHEP00000022320	ENSFHEP00000001731	ENSFHEP00000022320	GATA binding protein 1a.	BHLH domain-containing protein.	0.844
LOC105919611	LOC105933755	ENSFHEP00000001731	ENSFHEP00000030596	GATA binding protein 1a.	5-aminolevulinate synthase.	0.664
LOC105919611	LOC105935913	ENSFHEP00000001731	ENSFHEP00000032272	GATA binding protein 1a.	T-cell acute lymphocytic leukemia protein 1.	0.844
LOC105919611	lmo2	ENSFHEP00000001731	ENSFHEP00000026291	GATA binding protein 1a.	LIM domain only 2 (rhombotin-like 1).	0.964
LOC105919611	med1	ENSFHEP00000001731	ENSFHEP00000014059	GATA binding protein 1a.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.418
LOC105920540	ENSFHEP00000022320	ENSFHEP00000028444	ENSFHEP00000022320	Uncharacterized protein.	BHLH domain-containing protein.	0.844
LOC105920540	LOC105933755	ENSFHEP00000028444	ENSFHEP00000030596	Uncharacterized protein.	5-aminolevulinate synthase.	0.433
LOC105920540	LOC105935913	ENSFHEP00000028444	ENSFHEP00000032272	Uncharacterized protein.	T-cell acute lymphocytic leukemia protein 1.	0.844
LOC105920540	lmo2	ENSFHEP00000028444	ENSFHEP00000026291	Uncharacterized protein.	LIM domain only 2 (rhombotin-like 1).	0.964
LOC105920540	med1	ENSFHEP00000028444	ENSFHEP00000014059	Uncharacterized protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.418
LOC105926306	cftr	ENSFHEP00000013238	ENSFHEP00000008393	Histone deacetylase 9b.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	0.441
LOC105926861	LOC105933755	ENSFHEP00000017082	ENSFHEP00000030596	Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family.	5-aminolevulinate synthase.	0.544
LOC105926861	slc40a1	ENSFHEP00000017082	ENSFHEP00000027097	Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family.	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.	0.461
LOC105929932	PRKCA	ENSFHEP00000029675	ENSFHEP00000031032	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.943
LOC105929932	PRKCB	ENSFHEP00000029675	ENSFHEP00000003441	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Protein kinase C.	0.677
LOC105933755	LOC105919611	ENSFHEP00000030596	ENSFHEP00000001731	5-aminolevulinate synthase.	GATA binding protein 1a.	0.664
LOC105933755	LOC105920540	ENSFHEP00000030596	ENSFHEP00000028444	5-aminolevulinate synthase.	Uncharacterized protein.	0.433