(26 nodes) Positive regulation of protein dephosphorylation network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	vrk3	Inactive serine/threonine-protein kinase VRK3. (517 aa)
	sympk	Symplekin. (1244 aa)
	LOC105920636	Uncharacterized protein. (362 aa)
	pink1	PTEN induced kinase 1. (585 aa)
	LOC105935574	Membrane associated guanylate kinase, WW and PDZ domain containing 2b. (1538 aa)
	ppp1r42	Protein phosphatase 1, regulatory subunit 42. (314 aa)
	cdca2	PP1-binding domain-containing protein. (853 aa)
	LOC105917785	Phosphatase 1 regulatory subunit 15B. (599 aa)
	ankle2	Ankyrin repeat and LEM domain containing 2. (960 aa)
	cnep1r1	CTD nuclear envelope phosphatase 1 regulatory subunit 1. (125 aa)
	ENSFHEP00000032057	Uncharacterized protein. (959 aa)
	gba	Glucosylceramidase. (607 aa)
	ppp1r7	Protein phosphatase 1, regulatory (inhibitor) subunit 7. (350 aa)
	ptprc	Uncharacterized protein. (989 aa)
	LRRC43	Leucine rich repeat containing 43. (629 aa)
	ENSFHEP00000002273	PDZ domain-containing protein. (156 aa)
	ptpa	Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (322 aa)
	sppl3	Signal peptide peptidase 3-like protein. (383 aa)
	pawr	PRKC apoptosis WT1 regulator protein. (337 aa)
	LOC105933078	Transforming growth factor beta; Belongs to the TGF-beta family. (381 aa)
	LOC105926275	Protein phosphatase 1, regulatory subunit 15B. (553 aa)
	ambra1	Autophagy/beclin-1 regulator 1b. (769 aa)
	smpd1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (630 aa)
	tmem130	Transmembrane protein 130. (335 aa)
	LOC105929179	Angiotensin II receptor, type 2; Belongs to the G-protein coupled receptor 1 family. (412 aa)
	LOC105933301	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (718 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000002273	ENSFHEP00000032057	ENSFHEP00000002273	ENSFHEP00000032057	PDZ domain-containing protein.	Uncharacterized protein.	0.560
ENSFHEP00000002273	LOC105920636	ENSFHEP00000002273	ENSFHEP00000008931	PDZ domain-containing protein.	Uncharacterized protein.	0.586
ENSFHEP00000032057	ENSFHEP00000002273	ENSFHEP00000032057	ENSFHEP00000002273	Uncharacterized protein.	PDZ domain-containing protein.	0.560
LOC105920636	ENSFHEP00000002273	ENSFHEP00000008931	ENSFHEP00000002273	Uncharacterized protein.	PDZ domain-containing protein.	0.586
LOC105933301	ptprc	ENSFHEP00000010202	ENSFHEP00000034551	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	Uncharacterized protein.	0.564
ambra1	pink1	ENSFHEP00000017211	ENSFHEP00000006364	Autophagy/beclin-1 regulator 1b.	PTEN induced kinase 1.	0.490
gba	pink1	ENSFHEP00000033995	ENSFHEP00000006364	Glucosylceramidase.	PTEN induced kinase 1.	0.536
gba	smpd1	ENSFHEP00000033995	ENSFHEP00000016616	Glucosylceramidase.	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide.	0.972
pink1	ambra1	ENSFHEP00000006364	ENSFHEP00000017211	PTEN induced kinase 1.	Autophagy/beclin-1 regulator 1b.	0.490
pink1	gba	ENSFHEP00000006364	ENSFHEP00000033995	PTEN induced kinase 1.	Glucosylceramidase.	0.536
pink1	tmem130	ENSFHEP00000006364	ENSFHEP00000014919	PTEN induced kinase 1.	Transmembrane protein 130.	0.416
ptprc	LOC105933301	ENSFHEP00000034551	ENSFHEP00000010202	Uncharacterized protein.	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	0.564
smpd1	gba	ENSFHEP00000016616	ENSFHEP00000033995	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide.	Glucosylceramidase.	0.972
smpd1	tmem130	ENSFHEP00000016616	ENSFHEP00000014919	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide.	Transmembrane protein 130.	0.836
tmem130	pink1	ENSFHEP00000014919	ENSFHEP00000006364	Transmembrane protein 130.	PTEN induced kinase 1.	0.416
tmem130	smpd1	ENSFHEP00000014919	ENSFHEP00000016616	Transmembrane protein 130.	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide.	0.836