(50 nodes) Cellular response to decreased oxygen levels network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSFHEP00000009335	Uncharacterized protein. (190 aa)
	LOC105919467	TSC complex subunit 1. (1034 aa)
	LOC105931004	Cytoplasmic polyadenylation element binding protein 4a. (740 aa)
	pick1	Protein interacting with prkca 1. (393 aa)
	nkx3-1	NK3 homeobox 1. (187 aa)
	ENSFHEP00000032510	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (133 aa)
	fam167a	Family with sequence similarity 167 member Ab. (256 aa)
	nop53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (474 aa)
	cpeb1	Cytoplasmic polyadenylation element binding protein 1b. (577 aa)
	cpeb2	Cytoplasmic polyadenylation element binding protein 2. (756 aa)
	LOC105938430	Family with sequence similarity 162 member A. (158 aa)
	hyou1	Hypoxia up-regulated 1. (973 aa)
	eef2k	Eukaryotic elongation factor 2 kinase. (623 aa)
	vegfa	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
	aqp1	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (294 aa)
	hif1a	Hypoxia inducible factor 1 subunit alpha a. (754 aa)
	sirt1	Sirtuin 1. (719 aa)
	LOC105927179	Von Hippel-Lindau tumor suppressor. (173 aa)
	LOC105929979	Zgc:73226. (181 aa)
	epas1	Uncharacterized protein. (340 aa)
	bad	BCL2 associated agonist of cell death b. (209 aa)
	nfe2l2	Nuclear factor, erythroid 2-like 2a. (621 aa)
	pink1	PTEN induced kinase 1. (585 aa)
	ado	2-aminoethanethiol (cysteamine) dioxygenase b. (223 aa)
	mpl	MPL proto-oncogene, thrombopoietin receptor. (611 aa)
	hif1an	Hypoxia inducible factor 1 subunit alpha inhibitor. (354 aa)
	hif3alpha	Hypoxia inducible factor 1 subunit alpha, like. (603 aa)
	bnip3	BCL2 interacting protein 3. (204 aa)
	rbpj	Recombination signal binding protein for immunoglobulin kappa J region. (490 aa)
	bcl2	BCL2 apoptosis regulator b. (230 aa)
	ENSFHEP00000005022	Fe2OG dioxygenase domain-containing protein. (126 aa)
	egln1	Egl-9 family hypoxia-inducible factor 1a. (234 aa)
	LOC105935293	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1439 aa)
	ppard	Peroxisome proliferator-activated receptor delta b. (508 aa)
	LOC105921426	Fe2OG dioxygenase domain-containing protein. (276 aa)
	LOC105940147	2-aminoethanethiol dioxygenase. (258 aa)
	aifm1	Apoptosis inducing factor mitochondrion associated 1. (649 aa)
	rgcc	Regulator of cell cycle. (127 aa)
	ak4	GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (226 aa)
	fndc1	Fibronectin type III domain containing 1. (1824 aa)
	LOC105938762	Storkhead box 1. (1084 aa)
	tbl2	Transducin (beta)-like 2. (441 aa)
	LOC105936554	Egl-9 family hypoxia-inducible factor 2. (574 aa)
	LOC105921686	Recombination signal binding protein for immunoglobulin kappa J region a. (504 aa)
	LOC105927446	TSC complex subunit 1b. (1254 aa)
	ptgs2	Cyclooxygenase 2. (610 aa)
	sirt2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (382 aa)
	ndnf	Neuron-derived neurotrophic factor. (571 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2495 aa)
	LOC105933321	Endothelial PAS domain protein 1b. (873 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000005022	LOC105927179	ENSFHEP00000005022	ENSFHEP00000025310	Fe2OG dioxygenase domain-containing protein.	Von Hippel-Lindau tumor suppressor.	0.806
ENSFHEP00000005022	LOC105933321	ENSFHEP00000005022	ENSFHEP00000010408	Fe2OG dioxygenase domain-containing protein.	Endothelial PAS domain protein 1b.	0.846
ENSFHEP00000005022	egln1	ENSFHEP00000005022	ENSFHEP00000004816	Fe2OG dioxygenase domain-containing protein.	Egl-9 family hypoxia-inducible factor 1a.	0.900
ENSFHEP00000005022	epas1	ENSFHEP00000005022	ENSFHEP00000024953	Fe2OG dioxygenase domain-containing protein.	Uncharacterized protein.	0.908
ENSFHEP00000005022	hif1a	ENSFHEP00000005022	ENSFHEP00000025544	Fe2OG dioxygenase domain-containing protein.	Hypoxia inducible factor 1 subunit alpha a.	0.891
ENSFHEP00000005022	hif3alpha	ENSFHEP00000005022	ENSFHEP00000018459	Fe2OG dioxygenase domain-containing protein.	Hypoxia inducible factor 1 subunit alpha, like.	0.846
ENSFHEP00000009335	LOC105929979	ENSFHEP00000009335	ENSFHEP00000025080	Uncharacterized protein.	Zgc:73226.	0.964
ENSFHEP00000009335	aifm1	ENSFHEP00000009335	ENSFHEP00000001678	Uncharacterized protein.	Apoptosis inducing factor mitochondrion associated 1.	0.585
ENSFHEP00000009335	bad	ENSFHEP00000009335	ENSFHEP00000023862	Uncharacterized protein.	BCL2 associated agonist of cell death b.	0.977
ENSFHEP00000009335	bnip3	ENSFHEP00000009335	ENSFHEP00000018330	Uncharacterized protein.	BCL2 interacting protein 3.	0.966
ENSFHEP00000009335	pink1	ENSFHEP00000009335	ENSFHEP00000006364	Uncharacterized protein.	PTEN induced kinase 1.	0.678
ENSFHEP00000009335	sirt1	ENSFHEP00000009335	ENSFHEP00000025372	Uncharacterized protein.	Sirtuin 1.	0.633
ENSFHEP00000009335	sirt2	ENSFHEP00000009335	ENSFHEP00000011761	Uncharacterized protein.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.410
LOC105919467	LOC105927446	ENSFHEP00000007990	ENSFHEP00000013621	TSC complex subunit 1.	TSC complex subunit 1b.	0.911
LOC105919467	hyou1	ENSFHEP00000007990	ENSFHEP00000027295	TSC complex subunit 1.	Hypoxia up-regulated 1.	0.769
LOC105919467	mtor	ENSFHEP00000007990	ENSFHEP00000010587	TSC complex subunit 1.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.935
LOC105919467	pink1	ENSFHEP00000007990	ENSFHEP00000006364	TSC complex subunit 1.	PTEN induced kinase 1.	0.606
LOC105919467	ppard	ENSFHEP00000007990	ENSFHEP00000003618	TSC complex subunit 1.	Peroxisome proliferator-activated receptor delta b.	0.402
LOC105921426	LOC105927179	ENSFHEP00000002551	ENSFHEP00000025310	Fe2OG dioxygenase domain-containing protein.	Von Hippel-Lindau tumor suppressor.	0.806
LOC105921426	LOC105933321	ENSFHEP00000002551	ENSFHEP00000010408	Fe2OG dioxygenase domain-containing protein.	Endothelial PAS domain protein 1b.	0.846