(76 nodes) Hormone binding network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105926616	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (387 aa)
	LOC105936347	Abhydrolase domain-containing protein 2. (431 aa)
	ramp1	Receptor activity modifying protein 1. (150 aa)
	LOC105932858	Growth hormone releasing hormone receptor b; Belongs to the G-protein coupled receptor 2 family. (415 aa)
	ENSFHEP00000004656	Formyl peptide receptor 1; Belongs to the G-protein coupled receptor 1 family. (385 aa)
	LOC105932886	Adenylate cyclase activating polypeptide 1a (pituitary) receptor type I; Belongs to the G-protein coupled receptor 2 family. (456 aa)
	LOC105932666	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (379 aa)
	crhbp	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (320 aa)
	crym	Crystallin, mu. (322 aa)
	ramp2	Receptor (G protein-coupled) activity modifying protein 2. (215 aa)
	ENSFHEP00000006119	G protein-coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (356 aa)
	LOC105939090	Adiponectin receptor 1a. (377 aa)
	LOC105931052	Receptor activity-modifying protein 1. (151 aa)
	LOC110366720	Parathyroid hormone 1 receptor b; Belongs to the G-protein coupled receptor 2 family. (510 aa)
	LOC105926480	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (426 aa)
	LOC105918832	Glucagon receptor b; Belongs to the G-protein coupled receptor 2 family. (531 aa)
	LOC105932822	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (430 aa)
	LOC105937899	Guanylate cyclase. (998 aa)
	LOC105935507	Estrogen receptor 2b. (673 aa)
	ebi3	Epstein-Barr virus induced 3. (247 aa)
	LOC105937897	Uncharacterized protein. (448 aa)
	vipr1	Vasoactive intestinal peptide receptor 1b; Belongs to the G-protein coupled receptor 2 family. (449 aa)
	LOC105920525	Guanylate cyclase. (991 aa)
	LOC105921801	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (387 aa)
	gcgr	Glucagon receptor a; Belongs to the G-protein coupled receptor 2 family. (421 aa)
	LOC105936574	Growth hormone receptor b. (553 aa)
	LOC105935418	Estrogen receptor 2a. (553 aa)
	LOC105940391	Thyroid hormone receptor alpha. (413 aa)
	npr2	Guanylate cyclase. (1029 aa)
	ctsh	Uncharacterized protein; Belongs to the peptidase C1 family. (357 aa)
	npr1	Guanylate cyclase. (1046 aa)
	LOC105934904	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (447 aa)
	LOC105931326	Growth hormone receptor a. (620 aa)
	ENSFHEP00000017425	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (404 aa)
	LOC105932531	Pituitary adenylate cyclase-activating polypeptide type I receptor; Belongs to the G-protein coupled receptor 2 family. (447 aa)
	LOC105917983	Guanylate cyclase. (1053 aa)
	LOC105920893	Si:ch211-215j19.12; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (177 aa)
	LOC105920890	Growth hormone releasing hormone receptor a; Belongs to the G-protein coupled receptor 2 family. (423 aa)
	LOC105920883	Adenylate cyclase activating polypeptide 1a (pituitary) receptor type I; Belongs to the G-protein coupled receptor 2 family. (436 aa)
	LOC105931336	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
	LOC105926649	Guanylate cyclase. (1023 aa)
	ghrhr	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (387 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (620 aa)
	lepr	Leptin receptor. (997 aa)
	LOC105931285	Androgen receptor. (683 aa)
	AR	Androgen receptor. (752 aa)
	ENSFHEP00000022445	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
	c2cd2l	C2cd2 like. (701 aa)
	NR3C1	Nuclear receptor subfamily 3 group C member 1. (772 aa)
	pth2r	Parathyroid hormone 2 receptor; Belongs to the G-protein coupled receptor 2 family. (543 aa)
	LOC105916167	Cholecystokinin receptor type A; Belongs to the G-protein coupled receptor 1 family. (452 aa)
	galr1	Galanin receptor type 1; Belongs to the G-protein coupled receptor 1 family. (351 aa)
	LOC105919869	Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. (380 aa)
	slc40a1	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (565 aa)
	LOC105920641	Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor). (765 aa)
	ENSFHEP00000027958	ANF_receptor domain-containing protein. (233 aa)
	PRLR	Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin; Belongs to the type I cytokine receptor family. Type 1 subfamily. (317 aa)
	LOC105935007	Motilin receptor; Belongs to the G-protein coupled receptor 1 family. (306 aa)
	ENSFHEP00000029546	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (371 aa)
	sec61b	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (97 aa)
	LOC105926638	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (438 aa)
	LOC105921088	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (356 aa)
	LOC105929187	Endothelin B receptor; Belongs to the G-protein coupled receptor 1 family. (413 aa)
	LOC105916894	Galanin receptor 1a; Belongs to the G-protein coupled receptor 1 family. (355 aa)
	CCKAR	Cholecystokinin A receptor; Belongs to the G-protein coupled receptor 1 family. (458 aa)
	LOC105930293	Vasoactive intestinal peptide receptor 1a; Belongs to the G-protein coupled receptor 2 family. (447 aa)
	ABHD2	Abhydrolase domain-containing protein 2. (438 aa)
	LOC105935861	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (498 aa)
	thrb	Thyroid hormone receptor beta. (395 aa)
	LOC105930247	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (395 aa)
	adipor2	Adiponectin receptor 2. (371 aa)
	GLP2R	Glucagon like peptide 2 receptor; Belongs to the G-protein coupled receptor 2 family. (454 aa)
	ide	Insulin-degrading enzyme; Belongs to the peptidase M16 family. (1015 aa)
	LOC105933618	Endothelin receptor type Bb; Belongs to the G-protein coupled receptor 1 family. (424 aa)
	LOC105922135	ANF_receptor domain-containing protein. (167 aa)
	LOC105922123	Uncharacterized protein. (841 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	LOC105920641	ENSFHEP00000022152	ENSFHEP00000027740	Androgen receptor.	Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor).	0.604
AR	LOC105931285	ENSFHEP00000022152	ENSFHEP00000021977	Androgen receptor.	Androgen receptor.	0.948
AR	NR3C1	ENSFHEP00000022152	ENSFHEP00000023649	Androgen receptor.	Nuclear receptor subfamily 3 group C member 1.	0.604
AR	esr1	ENSFHEP00000022152	ENSFHEP00000021278	Androgen receptor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.617
CCKAR	LOC105916167	ENSFHEP00000031083	ENSFHEP00000025176	Cholecystokinin A receptor; Belongs to the G-protein coupled receptor 1 family.	Cholecystokinin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.927
CCKAR	LOC105934904	ENSFHEP00000031083	ENSFHEP00000015345	Cholecystokinin A receptor; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.949
ENSFHEP00000017425	GLP2R	ENSFHEP00000017425	ENSFHEP00000032628	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Glucagon like peptide 2 receptor; Belongs to the G-protein coupled receptor 2 family.	0.505
ENSFHEP00000017425	LOC105918832	ENSFHEP00000017425	ENSFHEP00000008598	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Glucagon receptor b; Belongs to the G-protein coupled receptor 2 family.	0.483
ENSFHEP00000017425	LOC105920883	ENSFHEP00000017425	ENSFHEP00000019310	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Adenylate cyclase activating polypeptide 1a (pituitary) receptor type I; Belongs to the G-protein coupled receptor 2 family.	0.479
ENSFHEP00000017425	LOC105920890	ENSFHEP00000017425	ENSFHEP00000019265	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Growth hormone releasing hormone receptor a; Belongs to the G-protein coupled receptor 2 family.	0.479
ENSFHEP00000017425	LOC105926638	ENSFHEP00000017425	ENSFHEP00000001066	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.483
ENSFHEP00000017425	LOC105930293	ENSFHEP00000017425	ENSFHEP00000031724	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Vasoactive intestinal peptide receptor 1a; Belongs to the G-protein coupled receptor 2 family.	0.492
ENSFHEP00000017425	LOC105931052	ENSFHEP00000017425	ENSFHEP00000007194	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Receptor activity-modifying protein 1.	0.624
ENSFHEP00000017425	LOC105932858	ENSFHEP00000017425	ENSFHEP00000004594	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Growth hormone releasing hormone receptor b; Belongs to the G-protein coupled receptor 2 family.	0.493
ENSFHEP00000017425	LOC105932886	ENSFHEP00000017425	ENSFHEP00000004663	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Adenylate cyclase activating polypeptide 1a (pituitary) receptor type I; Belongs to the G-protein coupled receptor 2 family.	0.488
ENSFHEP00000017425	gcgr	ENSFHEP00000017425	ENSFHEP00000013053	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Glucagon receptor a; Belongs to the G-protein coupled receptor 2 family.	0.500
ENSFHEP00000017425	ghrhr	ENSFHEP00000017425	ENSFHEP00000020885	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.479
ENSFHEP00000017425	ramp1	ENSFHEP00000017425	ENSFHEP00000004239	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Receptor activity modifying protein 1.	0.624
ENSFHEP00000017425	ramp2	ENSFHEP00000017425	ENSFHEP00000005660	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Receptor (G protein-coupled) activity modifying protein 2.	0.661
ENSFHEP00000017425	vipr1	ENSFHEP00000017425	ENSFHEP00000011437	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Vasoactive intestinal peptide receptor 1b; Belongs to the G-protein coupled receptor 2 family.	0.479