(19 nodes) Regulation of insulin-like growth factor receptor signaling pathway network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105939064	Insulin-like growth factor binding protein 6a. (181 aa)
	LOC105930782	Insulin-like growth factor binding protein 6b. (71 aa)
	LOC105935222	Insulin-like growth factor binding protein 1b. (363 aa)
	igf1	Insulin growth factor I-like protein. (185 aa)
	nkx3-1	NK3 homeobox 1. (187 aa)
	inppl1	Inositol polyphosphate phosphatase-like 1a. (1250 aa)
	igfbp2	Insulin-like growth factor binding protein 2a. (291 aa)
	IGFBP4	Insulin like growth factor binding protein 4. (259 aa)
	ENSFHEP00000009754	Insulin-like growth factor binding protein 6b. (130 aa)
	LOC105938942	Insulin-like growth factor binding protein 5a. (267 aa)
	LOC105938938	Insulin-like growth factor binding protein 2b. (265 aa)
	IGFBP3	Insulin like growth factor binding protein 3. (285 aa)
	LOC105925713	Inositol polyphosphate phosphatase-like 1b. (1079 aa)
	LOC105922967	Insulin-like growth factor binding protein 5a. (249 aa)
	LOC105935364	Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	LOC105931285	Androgen receptor. (683 aa)
	AR	Androgen receptor. (752 aa)
	LOC105932888	Insulin-like growth factor binding protein 3. (284 aa)
	LOC105932884	Insulin-like growth factor binding protein 1a. (256 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	LOC105931285	ENSFHEP00000022152	ENSFHEP00000021977	Androgen receptor.	Androgen receptor.	0.948
AR	nkx3-1	ENSFHEP00000022152	ENSFHEP00000032519	Androgen receptor.	NK3 homeobox 1.	0.564
ENSFHEP00000009754	igf1	ENSFHEP00000009754	ENSFHEP00000002734	Insulin-like growth factor binding protein 6b.	Insulin growth factor I-like protein.	0.890
IGFBP3	LOC105932888	ENSFHEP00000013773	ENSFHEP00000024613	Insulin like growth factor binding protein 3.	Insulin-like growth factor binding protein 3.	0.737
IGFBP3	igf1	ENSFHEP00000013773	ENSFHEP00000002734	Insulin like growth factor binding protein 3.	Insulin growth factor I-like protein.	0.991
IGFBP4	igf1	ENSFHEP00000004060	ENSFHEP00000002734	Insulin like growth factor binding protein 4.	Insulin growth factor I-like protein.	0.929
LOC105922967	igf1	ENSFHEP00000015726	ENSFHEP00000002734	Insulin-like growth factor binding protein 5a.	Insulin growth factor I-like protein.	0.970
LOC105925713	inppl1	ENSFHEP00000014532	ENSFHEP00000002188	Inositol polyphosphate phosphatase-like 1b.	Inositol polyphosphate phosphatase-like 1a.	0.936
LOC105930782	igf1	ENSFHEP00000027522	ENSFHEP00000002734	Insulin-like growth factor binding protein 6b.	Insulin growth factor I-like protein.	0.890
LOC105931285	AR	ENSFHEP00000021977	ENSFHEP00000022152	Androgen receptor.	Androgen receptor.	0.948
LOC105931285	nkx3-1	ENSFHEP00000021977	ENSFHEP00000032519	Androgen receptor.	NK3 homeobox 1.	0.564
LOC105932884	igf1	ENSFHEP00000024641	ENSFHEP00000002734	Insulin-like growth factor binding protein 1a.	Insulin growth factor I-like protein.	0.977
LOC105932888	IGFBP3	ENSFHEP00000024613	ENSFHEP00000013773	Insulin-like growth factor binding protein 3.	Insulin like growth factor binding protein 3.	0.737
LOC105932888	igf1	ENSFHEP00000024613	ENSFHEP00000002734	Insulin-like growth factor binding protein 3.	Insulin growth factor I-like protein.	0.975
LOC105935222	igf1	ENSFHEP00000030165	ENSFHEP00000002734	Insulin-like growth factor binding protein 1b.	Insulin growth factor I-like protein.	0.977
LOC105935364	igf1	ENSFHEP00000016352	ENSFHEP00000002734	Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family.	Insulin growth factor I-like protein.	0.418
LOC105938942	igf1	ENSFHEP00000011828	ENSFHEP00000002734	Insulin-like growth factor binding protein 5a.	Insulin growth factor I-like protein.	0.970
LOC105939064	igf1	ENSFHEP00000025869	ENSFHEP00000002734	Insulin-like growth factor binding protein 6a.	Insulin growth factor I-like protein.	0.890
igf1	ENSFHEP00000009754	ENSFHEP00000002734	ENSFHEP00000009754	Insulin growth factor I-like protein.	Insulin-like growth factor binding protein 6b.	0.890
igf1	IGFBP3	ENSFHEP00000002734	ENSFHEP00000013773	Insulin growth factor I-like protein.	Insulin like growth factor binding protein 3.	0.991