(59 nodes) Meiotic chromosome segregation network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	terb1	Telomere repeat binding bouquet formation protein 1. (654 aa)
	shoc1	Uncharacterized protein. (1417 aa)
	spata22	Spermatogenesis associated 22. (383 aa)
	top2a	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1525 aa)
	rad51c	RAD51 paralog C. (341 aa)
	ercc4	Excision repair cross-complementation group 4. (897 aa)
	dmc1	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa)
	ENSFHEP00000003134	Uncharacterized protein. (198 aa)
	spo11	SPO11 initiator of meiotic double stranded breaks. (336 aa)
	mus81	MUS81 structure-specific endonuclease subunit. (612 aa)
	ENSFHEP00000000374	Testis-expressed sequence 12 protein. (135 aa)
	sirt7	Sirtuin 7. (408 aa)
	LOC105932499	Zinc finger protein 473. (892 aa)
	ENSFHEP00000034851	TAN domain-containing protein. (173 aa)
	ncaph	Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (694 aa)
	LOC105925260	Zebrafish testis-expressed 38. (219 aa)
	ccnb1ip1	Cyclin B1 interacting protein 1. (263 aa)
	LOC105917492	BUB1 mitotic checkpoint serine/threonine kinase Bb. (435 aa)
	msh4	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (854 aa)
	trip13	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (422 aa)
	tex11	Testis expressed 11. (903 aa)
	ccne2	Cyclin E2; Belongs to the cyclin family. (395 aa)
	msh5	MutS homolog 5. (816 aa)
	LOC105930391	Uncharacterized protein. (222 aa)
	slx4	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1496 aa)
	ENSFHEP00000010787	BUB1 N-terminal domain-containing protein. (79 aa)
	ndc1	NDC1 transmembrane nucleoporin. (669 aa)
	LOC105937466	PSMC3 interacting protein. (219 aa)
	fancd2	FA complementation group D2. (1376 aa)
	eme1	Essential meiotic structure-specific endonuclease 1. (502 aa)
	cenpx	Centromere protein X. (95 aa)
	ttk	Ttk protein kinase. (1002 aa)
	C1orf146	Chromosome 1 open reading frame 146. (173 aa)
	hormad1	HORMA domain containing 1. (370 aa)
	ENSFHEP00000013605	Synaptonemal complex central element protein 2. (156 aa)
	ENSFHEP00000005371	Uncharacterized protein. (597 aa)
	ENSFHEP00000005309	Uncharacterized protein. (363 aa)
	sgo1	Shugoshin_C domain-containing protein. (646 aa)
	ccdc36	Uncharacterized protein. (432 aa)
	meiob	Methionine sulfoxide reductase B1b. (385 aa)
	smc4	Structural maintenance of chromosomes protein. (1271 aa)
	mlh3	WW domain-containing protein. (374 aa)
	sowahd	Uncharacterized protein. (178 aa)
	ankle1	Zgc:85936. (1133 aa)
	terb2	Telomere repeat binding bouquet formation protein 2. (213 aa)
	majin	Membrane anchored junction protein. (219 aa)
	ENSFHEP00000027515	Uncharacterized protein. (99 aa)
	ENSFHEP00000027829	Uncharacterized protein. (222 aa)
	nuf2	UF2 component of NDC80 kinetochore complex. (439 aa)
	LOC105934358	Uncharacterized protein. (1161 aa)
	mei4	Meiosis-specific MEI4-like protein. (373 aa)
	espl1	Extra spindle pole bodies like 1, separase. (2190 aa)
	ENSFHEP00000016572	TRF domain-containing protein. (154 aa)
	sycp1	Synaptonemal complex protein 1. (960 aa)
	top2b	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1605 aa)
	mlh1	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (715 aa)
	ENSFHEP00000019799	Ubiquitin-like domain-containing protein. (163 aa)
	rmi1	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (687 aa)
	ENSFHEP00000020833	Uncharacterized protein. (136 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1orf146	msh4	ENSFHEP00000027453	ENSFHEP00000014817	Chromosome 1 open reading frame 146.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.522
C1orf146	msh5	ENSFHEP00000027453	ENSFHEP00000012582	Chromosome 1 open reading frame 146.	MutS homolog 5.	0.469
C1orf146	tex11	ENSFHEP00000027453	ENSFHEP00000014364	Chromosome 1 open reading frame 146.	Testis expressed 11.	0.437
ENSFHEP00000003134	ENSFHEP00000005309	ENSFHEP00000003134	ENSFHEP00000005309	Uncharacterized protein.	Uncharacterized protein.	0.755
ENSFHEP00000003134	ENSFHEP00000005371	ENSFHEP00000003134	ENSFHEP00000005371	Uncharacterized protein.	Uncharacterized protein.	0.755
ENSFHEP00000003134	ENSFHEP00000010787	ENSFHEP00000003134	ENSFHEP00000010787	Uncharacterized protein.	BUB1 N-terminal domain-containing protein.	0.581
ENSFHEP00000003134	LOC105917492	ENSFHEP00000003134	ENSFHEP00000015568	Uncharacterized protein.	BUB1 mitotic checkpoint serine/threonine kinase Bb.	0.581
ENSFHEP00000003134	LOC105934358	ENSFHEP00000003134	ENSFHEP00000028205	Uncharacterized protein.	Uncharacterized protein.	0.581
ENSFHEP00000003134	espl1	ENSFHEP00000003134	ENSFHEP00000029175	Uncharacterized protein.	Extra spindle pole bodies like 1, separase.	0.845
ENSFHEP00000003134	ncaph	ENSFHEP00000003134	ENSFHEP00000035175	Uncharacterized protein.	Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.	0.998
ENSFHEP00000003134	nuf2	ENSFHEP00000003134	ENSFHEP00000027875	Uncharacterized protein.	UF2 component of NDC80 kinetochore complex.	0.721
ENSFHEP00000003134	sgo1	ENSFHEP00000003134	ENSFHEP00000029475	Uncharacterized protein.	Shugoshin_C domain-containing protein.	0.512
ENSFHEP00000003134	smc4	ENSFHEP00000003134	ENSFHEP00000031262	Uncharacterized protein.	Structural maintenance of chromosomes protein.	0.999
ENSFHEP00000003134	spo11	ENSFHEP00000003134	ENSFHEP00000002345	Uncharacterized protein.	SPO11 initiator of meiotic double stranded breaks.	0.405
ENSFHEP00000003134	top2a	ENSFHEP00000003134	ENSFHEP00000024530	Uncharacterized protein.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.879
ENSFHEP00000003134	top2b	ENSFHEP00000003134	ENSFHEP00000017208	Uncharacterized protein.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.879
ENSFHEP00000003134	trip13	ENSFHEP00000003134	ENSFHEP00000014379	Uncharacterized protein.	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family.	0.443
ENSFHEP00000003134	ttk	ENSFHEP00000003134	ENSFHEP00000026369	Uncharacterized protein.	Ttk protein kinase.	0.796
ENSFHEP00000005309	ENSFHEP00000003134	ENSFHEP00000005309	ENSFHEP00000003134	Uncharacterized protein.	Uncharacterized protein.	0.755
ENSFHEP00000005309	ENSFHEP00000005371	ENSFHEP00000005309	ENSFHEP00000005371	Uncharacterized protein.	Uncharacterized protein.	0.999