(31 nodes) Response to ethanol network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSFHEP00000030023	COesterase domain-containing protein. (275 aa)
	glra2	Glycine receptor subunit alpha-3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (452 aa)
	LOC105927766	Glycine receptor, alpha 4b; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (424 aa)
	ogg1	8-oxoguanine DNA glycosylase. (393 aa)
	LOC105915527	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	LOC105935293	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1439 aa)
	crhbp	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (320 aa)
	dmap1	DNA methyltransferase 1-associated protein 1. (486 aa)
	LOC105923269	Uncharacterized protein. (333 aa)
	ache	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (616 aa)
	LOC105936356	Solute carrier family 10 member 1. (348 aa)
	LOC105920049	Apolipoprotein Da, duplicate 2; Belongs to the calycin superfamily. Lipocalin family. (190 aa)
	LOC105920045	Apolipoprotein Da, duplicate 2; Belongs to the calycin superfamily. Lipocalin family. (179 aa)
	UNC79	Unc-79 homolog, NALCN channel complex subunit. (2385 aa)
	glra1	Glycine receptor, alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (447 aa)
	nr0b2	Nuclear receptor subfamily 0, group B, member 2a. (261 aa)
	LOC105925165	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (210 aa)
	ENSFHEP00000015847	Glycine receptor, alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (424 aa)
	tbxa2r	Thromboxane A2 receptor. (375 aa)
	LOC105920991	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	tufm	Tu translation elongation factor, mitochondrial. (432 aa)
	fgf19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	ENSFHEP00000018863	Uncharacterized protein. (153 aa)
	LOC105931336	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
	cd164	CD164 molecule, sialomucin. (171 aa)
	LOC105928781	Fibroblast growth factor receptor. (829 aa)
	psmd14	26S proteasome non-ATPase regulatory subunit 14. (310 aa)
	ENSFHEP00000024666	COesterase domain-containing protein. (163 aa)
	GRIN3A	Glutamate ionotropic receptor NMDA type subunit 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1079 aa)
	LOC105921138	Glycine receptor, alpha 4a; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (424 aa)
	tp53inp1	Tumor protein p53 inducible nuclear protein 1. (286 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000015847	glra1	ENSFHEP00000015847	ENSFHEP00000013444	Glycine receptor, alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	Glycine receptor, alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.900
ENSFHEP00000015847	glra2	ENSFHEP00000015847	ENSFHEP00000033687	Glycine receptor, alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	Glycine receptor subunit alpha-3; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.900
ENSFHEP00000024666	ENSFHEP00000030023	ENSFHEP00000024666	ENSFHEP00000030023	COesterase domain-containing protein.	COesterase domain-containing protein.	0.899
ENSFHEP00000030023	ENSFHEP00000024666	ENSFHEP00000030023	ENSFHEP00000024666	COesterase domain-containing protein.	COesterase domain-containing protein.	0.899
ENSFHEP00000030023	ache	ENSFHEP00000030023	ENSFHEP00000007433	COesterase domain-containing protein.	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	0.912
LOC105915527	LOC105920991	ENSFHEP00000002883	ENSFHEP00000016901	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.902
LOC105915527	LOC105925165	ENSFHEP00000002883	ENSFHEP00000015511	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.925
LOC105920991	LOC105915527	ENSFHEP00000016901	ENSFHEP00000002883	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.902
LOC105920991	LOC105925165	ENSFHEP00000016901	ENSFHEP00000015511	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.919
LOC105923269	nr0b2	ENSFHEP00000007020	ENSFHEP00000030118	Uncharacterized protein.	Nuclear receptor subfamily 0, group B, member 2a.	0.493
LOC105925165	LOC105915527	ENSFHEP00000015511	ENSFHEP00000002883	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.925
LOC105925165	LOC105920991	ENSFHEP00000015511	ENSFHEP00000016901	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.919
LOC105928781	fgf19	ENSFHEP00000021460	ENSFHEP00000018821	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.954
LOC105936356	nr0b2	ENSFHEP00000008261	ENSFHEP00000030118	Solute carrier family 10 member 1.	Nuclear receptor subfamily 0, group B, member 2a.	0.493
ache	ENSFHEP00000030023	ENSFHEP00000007433	ENSFHEP00000030023	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	COesterase domain-containing protein.	0.912
fgf19	LOC105928781	ENSFHEP00000018821	ENSFHEP00000021460	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.954
fgf19	nr0b2	ENSFHEP00000018821	ENSFHEP00000030118	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Nuclear receptor subfamily 0, group B, member 2a.	0.638
glra1	ENSFHEP00000015847	ENSFHEP00000013444	ENSFHEP00000015847	Glycine receptor, alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	Glycine receptor, alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.900
glra1	glra2	ENSFHEP00000013444	ENSFHEP00000033687	Glycine receptor, alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	Glycine receptor subunit alpha-3; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.717
glra2	ENSFHEP00000015847	ENSFHEP00000033687	ENSFHEP00000015847	Glycine receptor subunit alpha-3; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	Glycine receptor, alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.900